AR032072A1 - Derivados de quinuclidina novedosos y composiciones medicinales que los contienen - Google Patents
Derivados de quinuclidina novedosos y composiciones medicinales que los contienenInfo
- Publication number
- AR032072A1 AR032072A1 ARP010106065A ARP010106065A AR032072A1 AR 032072 A1 AR032072 A1 AR 032072A1 AR P010106065 A ARP010106065 A AR P010106065A AR P010106065 A ARP010106065 A AR P010106065A AR 032072 A1 AR032072 A1 AR 032072A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- straight
- hydrogen
- carbon atoms
- lower alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de la formula (1), en donde R es un anillo fenilo, un grupo heteroaromático de 5 a 10 miembros que contiene un grupo benzo[1,3]dioxolilo, o bifenilo, R1, R2 y R3 cada uno independientemente representa un átomo de hidrogeno o halogeno, o un grupo hidroxi, un grupo fenilo, -OR7, -SR7, -NR7R8-, grupo alquilo inferior sustituido o sin sustituir, en donde R7 y R8 cada uno independientemente representa un átomo de hidrogeno, un grupo alquilo inferior recto o ramificado, o conjuntamente forman un anillo alicíclico o R1 y R2 conjuntamente forman un anillo aromático o alicíclico o un grupo heterocíclico; n es un entero de 0 a 4; A representa un grupo seleccionado entre -CH2-, CH=CR9-, CR9=CH-, CR9R10-, -CO-, -O-, -S-, -S(O)2 y -NR9-, en donde R9 y R10 cada uno independientemente representa un átomo de hidrogeno, un grupo alquilo recto o ramificado de alquilo inferior, o conjuntamente forman un anillo alicíclico; m es un entero de 0 a 8, siempre que cuando m = 0, A no es -CH2-; p es un entero de 1 a 2 y la sustitucion del anillo bicíclico de azonia puede ser en la posicion 2, 3 o 4 incluyendo todas las configuraciones posibles de los carbonos asimétricos; R4 representa un grupo de estructura (2) en donde R11 representa un átomo de hidrogeno o halogeno, un grupo hidroxi, un grupo alcoxi, un grupo nitro, un grupo ciano, -CO2R12, o NR12R13, en donde R12 y R13 son idénticos o diferentes y son seleccionados entre hidrogeno y grupos de alquilo inferior recto o ramificado, o un grupo alquilo inferior recto o ramificado, sustituido o no sustituido; R5 representa un grupo alquilo de 1 a 7 átomos de carbono, un grupo alquenilo que contiene 2 a 7 átomos de carbono; un grupo alquinilo que contiene 2 a 7 átomos de carbono, un grupo cicloalquilo de 3 a 7 átomos de carbonos, o un grupo de la formula (3), en donde q = 1 o 2 y R11 es tal como se define anteriormente; R6 representa un átomo de hidrogeno, un grupo hidroxi, un grupo metilo, o un grupo CH2OH. El carbono asimétrico en la posicion alfa con respecto al grupo éster, que es sustituido por R4, R5 y R6 puede tener configuracion R o S; X- representa un anion farmacéuticamente aceptable de un ácido mono o polivalente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200003130 | 2000-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032072A1 true AR032072A1 (es) | 2003-10-22 |
Family
ID=8496180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010106065A AR032072A1 (es) | 2000-12-28 | 2001-12-27 | Derivados de quinuclidina novedosos y composiciones medicinales que los contienen |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US7122558B2 (es) |
| EP (1) | EP1353919B1 (es) |
| JP (1) | JP4295985B2 (es) |
| KR (1) | KR100869721B1 (es) |
| CN (1) | CN1250545C (es) |
| AR (1) | AR032072A1 (es) |
| AT (1) | ATE334128T1 (es) |
| AU (1) | AU2002238471B2 (es) |
| BG (1) | BG66162B1 (es) |
| BR (1) | BR0116624A (es) |
| CA (1) | CA2433128C (es) |
| CY (1) | CY1105719T1 (es) |
| CZ (1) | CZ301209B6 (es) |
| DE (1) | DE60121813T2 (es) |
| DK (1) | DK1353919T3 (es) |
| EC (1) | ECSP034672A (es) |
| EE (1) | EE05404B1 (es) |
| ES (1) | ES2266291T3 (es) |
| HK (1) | HK1055739A1 (es) |
| HU (1) | HUP0303524A3 (es) |
| IL (2) | IL156558A0 (es) |
| MX (1) | MXPA03005862A (es) |
| MY (1) | MY136067A (es) |
| NO (1) | NO328772B1 (es) |
| NZ (1) | NZ526674A (es) |
| PE (1) | PE20020721A1 (es) |
| PL (1) | PL363807A1 (es) |
| PT (1) | PT1353919E (es) |
| RU (1) | RU2282629C2 (es) |
| SI (1) | SI1353919T1 (es) |
| SK (1) | SK287414B6 (es) |
| UA (1) | UA75626C2 (es) |
| WO (1) | WO2002053564A2 (es) |
| ZA (1) | ZA200305008B (es) |
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| ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| ATE419236T1 (de) | 2002-07-08 | 2009-01-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo-3.1.0 hexan- derivate als muscarinische rezeptorantagonisten |
| EP1545508A4 (en) * | 2002-08-09 | 2009-11-25 | Ranbaxy Lab Ltd | 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS |
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| JPH0725756B2 (ja) | 1990-09-06 | 1995-03-22 | ファイザー・インコーポレーテッド | 抗ムスカリン性気管支拡張剤 |
| DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
| GB9119705D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic compounds |
| WO1995021820A1 (fr) | 1994-02-10 | 1995-08-17 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive du carbamate et composition correspondante |
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| EP0863141B1 (en) * | 1995-10-13 | 2001-09-12 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
| PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| US7214687B2 (en) * | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
| DK1300407T4 (da) | 2000-06-27 | 2011-09-05 | S A L V A T Lab Sa | Carbamater afledt af arylalkylaminer |
| AU2002228015B2 (en) * | 2000-12-22 | 2007-08-23 | Almirall, S.A. | Quinuclidine carbamate derivatives and their use as M3 antagonists |
| EP1353919B1 (en) * | 2000-12-28 | 2006-07-26 | Almirall Prodesfarma AG | Novel quinuclidine derivatives and medicinal compositions containing the same |
-
2001
- 2001-12-20 EP EP01986924A patent/EP1353919B1/en not_active Expired - Lifetime
- 2001-12-20 IL IL15655801A patent/IL156558A0/xx unknown
- 2001-12-20 SK SK799-2003A patent/SK287414B6/sk not_active IP Right Cessation
- 2001-12-20 PL PL01363807A patent/PL363807A1/xx unknown
- 2001-12-20 DE DE60121813T patent/DE60121813T2/de not_active Expired - Lifetime
- 2001-12-20 PT PT01986924T patent/PT1353919E/pt unknown
- 2001-12-20 SI SI200130596T patent/SI1353919T1/sl unknown
- 2001-12-20 EE EEP200300312A patent/EE05404B1/xx not_active IP Right Cessation
- 2001-12-20 WO PCT/EP2001/015168 patent/WO2002053564A2/en active IP Right Grant
- 2001-12-20 UA UA2003066042A patent/UA75626C2/uk unknown
- 2001-12-20 MX MXPA03005862A patent/MXPA03005862A/es active IP Right Grant
- 2001-12-20 AU AU2002238471A patent/AU2002238471B2/en not_active Ceased
- 2001-12-20 KR KR1020037008651A patent/KR100869721B1/ko not_active IP Right Cessation
- 2001-12-20 JP JP2002555087A patent/JP4295985B2/ja not_active Expired - Fee Related
- 2001-12-20 DK DK01986924T patent/DK1353919T3/da active
- 2001-12-20 BR BR0116624-7A patent/BR0116624A/pt not_active Application Discontinuation
- 2001-12-20 HU HU0303524A patent/HUP0303524A3/hu unknown
- 2001-12-20 ES ES01986924T patent/ES2266291T3/es not_active Expired - Lifetime
- 2001-12-20 AT AT01986924T patent/ATE334128T1/de active
- 2001-12-20 RU RU2003123120/04A patent/RU2282629C2/ru not_active IP Right Cessation
- 2001-12-20 CN CNB018222420A patent/CN1250545C/zh not_active Expired - Fee Related
- 2001-12-20 NZ NZ526674A patent/NZ526674A/en unknown
- 2001-12-20 CA CA2433128A patent/CA2433128C/en not_active Expired - Fee Related
- 2001-12-20 CZ CZ20031812A patent/CZ301209B6/cs not_active IP Right Cessation
- 2001-12-20 US US10/250,447 patent/US7122558B2/en not_active Expired - Fee Related
- 2001-12-26 PE PE2001001302A patent/PE20020721A1/es not_active Application Discontinuation
- 2001-12-27 MY MYPI20015907A patent/MY136067A/en unknown
- 2001-12-27 AR ARP010106065A patent/AR032072A1/es unknown
-
2003
- 2003-06-19 IL IL156558A patent/IL156558A/en not_active IP Right Cessation
- 2003-06-25 EC EC2003004672A patent/ECSP034672A/es unknown
- 2003-06-26 ZA ZA2003/05008A patent/ZA200305008B/en unknown
- 2003-06-27 BG BG107950A patent/BG66162B1/bg unknown
- 2003-06-30 NO NO20033002A patent/NO328772B1/no not_active IP Right Cessation
- 2003-11-10 HK HK03108123A patent/HK1055739A1/xx not_active IP Right Cessation
-
2006
- 2006-08-31 US US11/515,335 patent/US7893087B2/en not_active Expired - Fee Related
- 2006-08-31 US US11/514,590 patent/US7879874B2/en not_active Expired - Fee Related
- 2006-10-20 CY CY20061101508T patent/CY1105719T1/el unknown
-
2010
- 2010-05-21 US US12/785,345 patent/US20100234332A1/en not_active Abandoned
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