AR059076A1 - Tiofenil y pirrolil azepinas como ligandos del receptor 5-ht2c de serotonina y usos de las mismas - Google Patents
Tiofenil y pirrolil azepinas como ligandos del receptor 5-ht2c de serotonina y usos de las mismasInfo
- Publication number
- AR059076A1 AR059076A1 ARP070100226A ARP070100226A AR059076A1 AR 059076 A1 AR059076 A1 AR 059076A1 AR P070100226 A ARP070100226 A AR P070100226A AR P070100226 A ARP070100226 A AR P070100226A AR 059076 A1 AR059076 A1 AR 059076A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- group
- compounds
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente se refiere en general a una serie de compuestos, a composiciones farmacéuticas que contienen dichos compuestos y al uso de los compuestos y composiciones como agentes terapéuticos. Más específicamente, los compuestos de la presente son compuestos de tiofenil y pirrolil azepina. Estos compuestos son ligandos del receptor de serotonina (5-HT2c) y son utiles en el tratamiento de enfermedades, trastornos y estados en los que se desea la modulacion de la actividad de los receptores de serotonina (5-HT2c) (p. ej. adiccion, ansiedad, depresion, obesidad y otros). Reivindicacion 1: Un compuesto de formula (1) donde X es S o NR11; R1 y R2 se seleccionan independientemente del grupo formado por H, halogeno, aIquilo C1-8, alquenilo C2-8, alquinilo C2-8, perhaloalquilo, alquil C1-8-perhaloalquilo, -CN, OR8, SR8, -SO2R10, -C(=O)R10, -C(=O)NR8R9, -NR8CO2R10, - SO2NR8R9, -NR8SO2R10, arilo o heteroarilo, alquil C1-8-arilo o heteroarilo, -alquiI C1-8-O-alquilo C1-8, y - alquil C1-8-O-arilo o heteroarilo; R1 y R2 tomados en forma conjunta con los átomos a los cuales están ligados pueden formar un carbociclo o heterociclo de 5 a 7 miembros opcionalmente sustituido con hasta dos sustituyentes seleccionados entre alquilo CF3 y -OR8; R3 se selecciona del grupo formado por H, alquilo C1-8, OR8, arilo y heteroarilo; R3a es H o alquilo C1-8 o R3 y R3a tomados en forma conjunta son -CH2CH2-; R2 y R3 tomados en forma conjunta forman un carbociclo o heterociclo de 5 a 7 miembros opcionalmente sustituido con hasta dos sustituyentes seleccionados entre alquilo, CF3 y -OR8, R4 es H, alquilo C1-8 o OR8; R4a es H, alquilo C1-8; o R4 y R4a tomados en forma conjunta son -CH2CH2-; R5 se selecciona del grupo formado por H, -alquilo C1-8, -alquiI C1-8-O- alquiloC1-8, alquil C1-8-arilo o heteroarilo, y -alquil C1-8-O-arilo o heteroarilo; R5a es H o -alquilo C1-8; R6 se selecciona del grupo formado por H, -alquilo C1-8, alquil C1-8-O-alquilo C1-8, alquil C1-8- arilo o heteroarilo, y -alquiI C1-8-O-arilo o heteroarilo; R6a es H o -alquil C1-8; R7 se selecciona del grupo formado por H, -aIquilo C1-8 y -alquil C1-8-arilo o heteroarilo; R8, R9 se seleccionan independientemente del grupo formado por H, - alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, arilo o heteroarilo, -alquil C1-8-arilo o heteroarilo, -alquil C1-8-O-alquilo C1-8 y -aIquil C1-8-O-ariIo o heteroarilo; R8 y R9 tomados en forma conjunta con el átomo al cual están ligados forman un heterociclo de 5 a 7 miembros; R10 se selecciona del grupo formado por -alquilo C1-8, -alquenilo C2-8, - alquinilo C2-8, arilo o heteroarilo, -alquil C1-8-arilo o heteroarilo, -alquil C1-8-O-alquilo C1-8, y -alquil C1-8-O-arilo o heteroarilo; R11 se selecciona del grupo formado por H, -alquilo C1-8, -alquil C1-8-O-alquilo C1-8, -SO2R10, -C(=O)R10, -C(=O)OR10, arilo y heteroarilo o alquiI C1-8-arilo o heteroarilo; R11 y R1 junto con los átomos a los cuales están ligados pueden formar un heterociclo de 5 a 7 miembros opcionalmente sustituido con hasta dos sustituyentes seleccionados entre alquilo C1-8, CF3 y -OR8; y R11 y R4 junto con los átomos a los cuales están ligados pueden forman un heterociclo de 5 a 7 miembros opcionalmente sustituido con hasta dos sustituyentes seleccionados entre -alquilo C1-8, CF3 y -OR8; donde arilo y heteroarilo están opcionalmente sustituidos con hasta dos sustituyentes seleccionados entre -alquilo C1-8, halogeno, CN y alcoxi y las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76024006P | 2006-01-19 | 2006-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059076A1 true AR059076A1 (es) | 2008-03-12 |
Family
ID=38288237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100226A AR059076A1 (es) | 2006-01-19 | 2007-01-18 | Tiofenil y pirrolil azepinas como ligandos del receptor 5-ht2c de serotonina y usos de las mismas |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7893051B2 (es) |
| EP (1) | EP1981337B1 (es) |
| JP (1) | JP5188986B2 (es) |
| KR (2) | KR20080107375A (es) |
| CN (1) | CN101404882A (es) |
| AR (1) | AR059076A1 (es) |
| AU (1) | AU2007207508B2 (es) |
| BR (1) | BRPI0707183A2 (es) |
| CA (1) | CA2636992C (es) |
| IL (1) | IL192744A0 (es) |
| MX (1) | MX2008009178A (es) |
| NO (1) | NO20083481L (es) |
| NZ (1) | NZ569554A (es) |
| RU (1) | RU2434872C2 (es) |
| TW (1) | TWI402272B (es) |
| WO (1) | WO2007084622A2 (es) |
| ZA (1) | ZA200805915B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| WO2011071136A1 (ja) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| US8217183B2 (en) * | 2010-05-18 | 2012-07-10 | Corning Incorporated | Methods of making fused thiophenes |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2824106B1 (en) | 2012-03-06 | 2016-11-23 | Takeda Pharmaceutical Company Limited | Tricyclic compound |
| US9309262B2 (en) | 2013-03-13 | 2016-04-12 | Abt Holding Company | Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652588A (en) * | 1969-10-23 | 1972-03-28 | Upjohn Co | 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles |
| ZA821020B (en) * | 1981-02-18 | 1983-10-26 | Thomae Gmbh Dr K | Azepine derivatives, process for their preparation and pharmaceutical compositions thereof |
| CH649553A5 (de) * | 1982-05-06 | 1985-05-31 | Sandoz Ag | Azepinoindole und verfahren zu deren herstellung. |
| DE3230696A1 (de) | 1982-08-18 | 1984-02-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8800891D0 (en) * | 1988-01-15 | 1988-02-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB9025890D0 (en) | 1990-11-28 | 1991-01-09 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5532240A (en) | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| KR930703327A (ko) | 1991-12-26 | 1993-11-29 | 고야 다다시 | 축합형 티오펜 화합물 및 그의 의약용도 |
| CN1160403A (zh) | 1994-10-11 | 1997-09-24 | 武田药品工业株式会社 | 取代杂双环烷基胺和它们作为角鲨烯氧化物环化酶抑制剂的用途 |
| US6407092B1 (en) * | 1999-04-23 | 2002-06-18 | Pharmacia & Upjohn Company | Tetracyclic azepinoindole compounds |
| PE20010052A1 (es) * | 1999-04-23 | 2001-01-27 | Upjohn Co | Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht |
| DE60014083T2 (de) * | 1999-06-15 | 2006-03-02 | Bristol-Myers Squibb Pharma Co., Wilmington | Substituierte heterocyclylkondensierte gamma carboline |
| EP1319005A2 (en) * | 2000-09-20 | 2003-06-18 | PHARMACIA & UPJOHN COMPANY | Substituted azepino[4,5-b]indoline derivatives |
| WO2002051418A1 (en) | 2000-12-22 | 2002-07-04 | F. Hoffmann-La Roche Ag | Tetrahydro-(benzo or thieno)-azepine-pyrazine and triazine derivatives as mglur 1 antagonists |
| DE60325985D1 (de) | 2002-09-12 | 2009-03-12 | Merck & Co Inc | Substituierte bizyklische thiophen-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren |
| EA016558B1 (ru) | 2003-06-17 | 2012-05-30 | Арена Фармасьютикалз, Инк. | Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором |
| AU2004267016B2 (en) | 2003-06-17 | 2011-11-24 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases |
| EP1668014B1 (en) * | 2003-09-17 | 2009-01-14 | Janssen Pharmaceutica N.V. | Fused heterocyclic compounds as serotonin receptor modulators |
| US20080009478A1 (en) | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| US20070275949A1 (en) | 2003-10-22 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases |
| CN1980710B (zh) * | 2004-06-30 | 2013-06-12 | 阿特西斯公司 | 作为5-羟色胺受体调节剂的取代的氮杂环庚烯衍生物 |
-
2007
- 2007-01-17 AU AU2007207508A patent/AU2007207508B2/en not_active Ceased
- 2007-01-17 EP EP07718077.6A patent/EP1981337B1/en not_active Not-in-force
- 2007-01-17 KR KR1020087020239A patent/KR20080107375A/ko not_active Application Discontinuation
- 2007-01-17 KR KR1020147012091A patent/KR101503681B1/ko not_active IP Right Cessation
- 2007-01-17 WO PCT/US2007/001345 patent/WO2007084622A2/en active Application Filing
- 2007-01-17 RU RU2008133980/04A patent/RU2434872C2/ru not_active IP Right Cessation
- 2007-01-17 CA CA2636992A patent/CA2636992C/en not_active Expired - Fee Related
- 2007-01-17 US US11/654,979 patent/US7893051B2/en not_active Expired - Fee Related
- 2007-01-17 JP JP2008551392A patent/JP5188986B2/ja not_active Expired - Fee Related
- 2007-01-17 NZ NZ569554A patent/NZ569554A/en not_active IP Right Cessation
- 2007-01-17 CN CNA2007800097927A patent/CN101404882A/zh active Pending
- 2007-01-17 BR BRPI0707183-3A patent/BRPI0707183A2/pt not_active IP Right Cessation
- 2007-01-17 MX MX2008009178A patent/MX2008009178A/es active IP Right Grant
- 2007-01-18 AR ARP070100226A patent/AR059076A1/es unknown
- 2007-01-19 TW TW096102154A patent/TWI402272B/zh not_active IP Right Cessation
-
2008
- 2008-07-07 ZA ZA200805915A patent/ZA200805915B/xx unknown
- 2008-07-10 IL IL192744A patent/IL192744A0/en unknown
- 2008-08-12 NO NO20083481A patent/NO20083481L/no not_active Application Discontinuation
-
2011
- 2011-01-12 US US13/005,395 patent/US8716276B2/en not_active Expired - Fee Related
-
2014
- 2014-03-19 US US14/219,304 patent/US20140206672A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ569554A (en) | 2011-10-28 |
| US20110112072A1 (en) | 2011-05-12 |
| EP1981337B1 (en) | 2015-09-02 |
| CA2636992A1 (en) | 2007-07-26 |
| AU2007207508A1 (en) | 2007-07-26 |
| US8716276B2 (en) | 2014-05-06 |
| CN101404882A (zh) | 2009-04-08 |
| WO2007084622A3 (en) | 2007-12-21 |
| RU2008133980A (ru) | 2010-02-27 |
| US20140206672A1 (en) | 2014-07-24 |
| TWI402272B (zh) | 2013-07-21 |
| AU2007207508B2 (en) | 2011-08-18 |
| US7893051B2 (en) | 2011-02-22 |
| JP5188986B2 (ja) | 2013-04-24 |
| US20070191342A1 (en) | 2007-08-16 |
| WO2007084622A2 (en) | 2007-07-26 |
| CA2636992C (en) | 2015-10-06 |
| BRPI0707183A2 (pt) | 2011-04-26 |
| ZA200805915B (en) | 2009-04-29 |
| KR20080107375A (ko) | 2008-12-10 |
| EP1981337A4 (en) | 2010-08-11 |
| MX2008009178A (es) | 2008-12-05 |
| TW200738732A (en) | 2007-10-16 |
| JP2009523809A (ja) | 2009-06-25 |
| IL192744A0 (en) | 2009-02-11 |
| KR101503681B1 (ko) | 2015-03-19 |
| KR20140062185A (ko) | 2014-05-22 |
| NO20083481L (no) | 2008-08-12 |
| RU2434872C2 (ru) | 2011-11-27 |
| EP1981337A2 (en) | 2008-10-22 |
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