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AR030933A1 - Derivados del triazol y composiciones farmaceuticas que los contienen - Google Patents

Derivados del triazol y composiciones farmaceuticas que los contienen

Info

Publication number
AR030933A1
AR030933A1 ARP010102360A ARP010102360A AR030933A1 AR 030933 A1 AR030933 A1 AR 030933A1 AR P010102360 A ARP010102360 A AR P010102360A AR P010102360 A ARP010102360 A AR P010102360A AR 030933 A1 AR030933 A1 AR 030933A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical compositions
derivatives
compositions containing
triazole
substituents
Prior art date
Application number
ARP010102360A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR030933A1 publication Critical patent/AR030933A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se describe una composicion farmacéutica con una actividad inhibidora del transporte de glicina, que en calidad de ingrediente activo contiene derivado del triazol de formula general (1) o una sal aceptable para uso farmacéutico del mismo, donde los sustituyentes tienen los significados indicados en la memoria descriptiva. Asimismo se describen derivados del triazol de formulas (2) y (3), o una sal de los mismo, donde los sustituyentes tienen los significados indicados en la memoria descriptiva, y las composiciones farmacéuticas que en calidad de ingrediente activo contienen un compuesto de formulas (2) o (3) o una sal aceptable para uso farmacéutico del mismo. Estos derivados del triazol tienen una excelente actividad inhibidora del transporte de glicina y son utiles como agentes terapéuticos.
ARP010102360A 2000-05-19 2001-05-18 Derivados del triazol y composiciones farmaceuticas que los contienen AR030933A1 (es)

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US7084164B2 (en) 2006-08-01
CZ20023763A3 (cs) 2003-03-12
NO20025517L (no) 2002-11-18
NO20025517D0 (no) 2002-11-18
CA2409819A1 (en) 2002-11-18
AU2001256769A1 (en) 2001-11-26
HUP0302415A2 (hu) 2003-11-28
CA2409819C (en) 2009-09-15
PL359340A1 (en) 2004-08-23
US20060025461A1 (en) 2006-02-02
EP1293503A1 (en) 2003-03-19
RU2002133666A (ru) 2007-05-10
CN1237055C (zh) 2006-01-18
CN1429215A (zh) 2003-07-09
KR20030019386A (ko) 2003-03-06
MXPA02011373A (es) 2003-06-26
KR100776119B1 (ko) 2007-11-16
SK16242002A3 (sk) 2003-04-01
WO2001087855A1 (fr) 2001-11-22
BR0110961A (pt) 2004-06-29
JP3873746B2 (ja) 2007-01-24
EP1293503A4 (en) 2008-04-02

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