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AR029752A1 - Compuesto derivado de pirazinona policiclica, sustituida, composicion que lo comprende y el uso,de dicha composicion y de dicho compuesto en la fabricacion de medicamentos utiles para la inhibicion selectiva de la cascada de coagulacion - Google Patents

Compuesto derivado de pirazinona policiclica, sustituida, composicion que lo comprende y el uso,de dicha composicion y de dicho compuesto en la fabricacion de medicamentos utiles para la inhibicion selectiva de la cascada de coagulacion

Info

Publication number
AR029752A1
AR029752A1 ARP000102447A ARP000102447A AR029752A1 AR 029752 A1 AR029752 A1 AR 029752A1 AR P000102447 A ARP000102447 A AR P000102447A AR P000102447 A ARP000102447 A AR P000102447A AR 029752 A1 AR029752 A1 AR 029752A1
Authority
AR
Argentina
Prior art keywords
composition
compound
manufacture
pirazinona
police
Prior art date
Application number
ARP000102447A
Other languages
English (en)
Inventor
Michael South
John Parlow
Melvin L Rueppel
Danin Jones
Brenda Case
Tom Dice
Richard Lindmark
Michael Hayes
Rick Fenton
Gary Franklin
Wei Huang
Larrie Kusturin
Jason M Long
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR029752A1 publication Critical patent/AR029752A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invencion se relaciona con compuestos de aril û y heteroaril û pirazinonas policíclicas sustituidas de formula (1) donde los sustituyentes son lo que se definen en la memoria descriptiva y reivindicaciones, utiles como inhibidores de serina proteasas de la cascada de coagulacion; compuestos; composiciones y el uso de los mismos en la fabricacion de medicamentos utiles en el tratamiento y prevencion de diversas afecciones tromboticas que incluyen enfermedades de la arteria coronaria y enfermedades cerebrovasculares.
ARP000102447A 1999-05-19 2000-05-19 Compuesto derivado de pirazinona policiclica, sustituida, composicion que lo comprende y el uso,de dicha composicion y de dicho compuesto en la fabricacion de medicamentos utiles para la inhibicion selectiva de la cascada de coagulacion AR029752A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13495899P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
AR029752A1 true AR029752A1 (es) 2003-07-16

Family

ID=22465803

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102447A AR029752A1 (es) 1999-05-19 2000-05-19 Compuesto derivado de pirazinona policiclica, sustituida, composicion que lo comprende y el uso,de dicha composicion y de dicho compuesto en la fabricacion de medicamentos utiles para la inhibicion selectiva de la cascada de coagulacion

Country Status (24)

Country Link
EP (1) EP1202975B1 (es)
JP (1) JP2002544264A (es)
KR (1) KR20010113971A (es)
CN (1) CN1351595A (es)
AR (1) AR029752A1 (es)
AT (1) ATE292629T1 (es)
AU (1) AU775229B2 (es)
BR (1) BR0011295A (es)
CA (1) CA2372617A1 (es)
CZ (1) CZ20014115A3 (es)
DE (1) DE60019296T2 (es)
EA (1) EA005031B1 (es)
ES (1) ES2240100T3 (es)
HU (1) HUP0202191A3 (es)
IL (1) IL146245A0 (es)
MX (1) MXPA01011807A (es)
NO (1) NO20015605L (es)
NZ (1) NZ514876A (es)
PE (1) PE20010290A1 (es)
PL (1) PL352368A1 (es)
SK (1) SK15872001A3 (es)
UY (1) UY26155A1 (es)
WO (1) WO2000069834A1 (es)
ZA (2) ZA200109341B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58636C2 (uk) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
EP1259506A1 (en) 1999-11-23 2002-11-27 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO2001079195A2 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
US6506754B1 (en) * 2000-04-14 2003-01-14 Corvas International, Inc. Non-covalent thrombin inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7243153B2 (en) 2001-06-26 2007-07-10 Eastman Kodak Company System and method for managing images over a communication network
MXPA04003167A (es) * 2001-10-03 2004-07-08 Pharmacia Corp Compuestos heterociclicos insaturados de 6 miembros utiles para la inhibicion selectiva de la cascada de coagulacion.
BR0213099A (pt) * 2001-10-03 2004-10-19 Pharmacia Corp Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação
CA2462601A1 (en) * 2001-10-03 2003-04-10 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
EP1526131A1 (en) * 2003-10-22 2005-04-27 Graffinity Pharmaceuticals Aktiengesellschaft Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors
US7905872B2 (en) * 2004-06-04 2011-03-15 The Procter & Gamble Company Absorbent articles comprising a slow recovery stretch laminate
US9017305B2 (en) 2010-11-12 2015-04-28 The Procter Gamble Company Elastomeric compositions that resist force loss and disintegration
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
CN119350433A (zh) 2018-05-29 2025-01-24 奥默罗斯公司 Masp-2抑制剂和使用方法
CA3147564A1 (en) 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
BR112022010881A2 (pt) 2019-12-04 2022-08-23 Omeros Corp Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado a serina protease-2 associada à lectina de ligação ao manan
US12030853B2 (en) 2019-12-04 2024-07-09 Omeros Corporation MASP-2 inhibitors and methods of use
IL293588A (en) * 2019-12-04 2022-08-01 Omeros Corp Masp-2 inhibitor compounds, compositions comprising same and uses thereof
KR20220110530A (ko) 2019-12-04 2022-08-08 오메로스 코포레이션 Masp-2 억제자 및 사용 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU703744B2 (en) * 1995-06-27 1999-04-01 Merck & Co., Inc. Pyridinone-thrombin inhibitors
DE69709727T2 (de) * 1996-04-23 2002-08-08 MERCK & CO., INC. Parazinon thrombin inhibitoren
EP0969840A4 (en) * 1997-03-24 2001-02-28 Merck & Co Inc THROMBIN INHIBITORS
JP2001514227A (ja) * 1997-09-05 2001-09-11 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
CA2329914A1 (en) * 1998-05-19 1999-11-25 Merck & Co., Inc. Pyrazinone thrombin inhibitors
JP2002516326A (ja) * 1998-05-26 2002-06-04 メルク エンド カムパニー インコーポレーテッド イミダゾピリジン系トロンビン阻害薬
CN1224629C (zh) * 1998-06-11 2005-10-26 三维药物公司 吡嗪酮蛋白酶抑制剂

Also Published As

Publication number Publication date
EP1202975A1 (en) 2002-05-08
ATE292629T1 (de) 2005-04-15
MXPA01011807A (es) 2003-09-04
EP1202975B1 (en) 2005-04-06
DE60019296T2 (de) 2006-03-09
BR0011295A (pt) 2002-05-28
CA2372617A1 (en) 2000-11-23
HUP0202191A2 (hu) 2002-12-28
NZ514876A (en) 2005-03-24
JP2002544264A (ja) 2002-12-24
CN1351595A (zh) 2002-05-29
DE60019296D1 (de) 2005-05-12
EA005031B1 (ru) 2004-10-28
UY26155A1 (es) 2000-12-29
KR20010113971A (ko) 2001-12-28
SK15872001A3 (sk) 2002-10-08
NO20015605L (no) 2002-01-18
ES2240100T3 (es) 2005-10-16
NO20015605D0 (no) 2001-11-16
IL146245A0 (en) 2002-07-25
ZA200109341B (en) 2004-05-26
ZA200400455B (en) 2004-09-29
WO2000069834A1 (en) 2000-11-23
EA200101212A1 (ru) 2002-06-27
CZ20014115A3 (cs) 2002-05-15
AU4972300A (en) 2000-12-05
HUP0202191A3 (en) 2003-02-28
PL352368A1 (en) 2003-08-25
AU775229B2 (en) 2004-07-22
PE20010290A1 (es) 2001-03-07

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