AR023679A1 - Delta3-piperidinas triciclicas como antagonistas de alfa2, un proceso para su preparacion, una composicion farmaceutica y el uso del mismo para la elaboracion de un medicamento - Google Patents
Delta3-piperidinas triciclicas como antagonistas de alfa2, un proceso para su preparacion, una composicion farmaceutica y el uso del mismo para la elaboracion de un medicamentoInfo
- Publication number
- AR023679A1 AR023679A1 ARP990105041A ARP990105041A AR023679A1 AR 023679 A1 AR023679 A1 AR 023679A1 AR P990105041 A ARP990105041 A AR P990105041A AR P990105041 A ARP990105041 A AR P990105041A AR 023679 A1 AR023679 A1 AR 023679A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- anfagist
- piperidins
- alfa2
- delta3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a los compuestos de la formula (1), las formas de N-oxido, las sales de adicion farmacéuticamente aceptables y las formasesteroquímicamente isoméricas de los mismos, donde Alk es alcanodiilo C1-6; n es 1 o 2; X es -O- , -S-, S(=O) o S(0)2-; cada R1 es independientemente hidrogenohalogeno, alquilo C1-6, nitro, hidroxi o alquiloxi C1-4; D es un indol, un bencisoxazol, un bencisotiazol, una 2H-benzopiranona, un fenoxifenilo, unabenzamida, una benzofenona o unabenzop irimidona con actividad antagonista del adrenorreceptor alfa2 central. También se relaciona con su preparacion, su usofarmacéutico y composiciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203371 | 1998-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023679A1 true AR023679A1 (es) | 2002-09-04 |
Family
ID=8234192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105041A AR023679A1 (es) | 1998-10-06 | 1999-10-05 | Delta3-piperidinas triciclicas como antagonistas de alfa2, un proceso para su preparacion, una composicion farmaceutica y el uso del mismo para la elaboracion de un medicamento |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6352999B1 (es) |
| EP (1) | EP1119570B1 (es) |
| JP (1) | JP4590102B2 (es) |
| KR (1) | KR20010071844A (es) |
| CN (1) | CN1131868C (es) |
| AR (1) | AR023679A1 (es) |
| AT (1) | ATE269337T1 (es) |
| AU (1) | AU759199B2 (es) |
| BG (1) | BG64871B1 (es) |
| BR (1) | BR9913108A (es) |
| CA (1) | CA2346082C (es) |
| CZ (1) | CZ20011105A3 (es) |
| DE (1) | DE69918148T2 (es) |
| EE (1) | EE04680B1 (es) |
| ES (1) | ES2222735T3 (es) |
| HK (1) | HK1038009A1 (es) |
| HU (1) | HUP0103749A3 (es) |
| ID (1) | ID28451A (es) |
| IL (2) | IL142444A0 (es) |
| NO (1) | NO20011402D0 (es) |
| NZ (1) | NZ510116A (es) |
| PL (1) | PL347179A1 (es) |
| RU (1) | RU2226194C2 (es) |
| SK (1) | SK285386B6 (es) |
| TR (1) | TR200100953T2 (es) |
| TW (1) | TWI244485B (es) |
| UA (1) | UA70961C2 (es) |
| WO (1) | WO2000020423A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA69420C2 (uk) * | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ |
| MXPA04000036A (es) * | 2001-07-05 | 2004-05-21 | Upjohn Co | Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht. |
| WO2003082825A1 (en) * | 2002-04-03 | 2003-10-09 | Orion Corporation | Use of an alfa2-adrenoreceptor antagonist for cns-related diseases |
| AU2005233456A1 (en) | 2004-04-12 | 2005-10-27 | Taisho Pharmaceutical Co., Ltd. | Cyclic amine compound |
| US7297704B2 (en) | 2005-02-17 | 2007-11-20 | Wyeth | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| KR101595183B1 (ko) | 2013-07-25 | 2016-02-17 | 동아에스티 주식회사 | 벤즈아미드 유도체의 제조방법, 그의 제조에 사용되는 새로운 중간체 및 상기 중간체의 제조방법 |
| CN103755715B (zh) * | 2013-12-26 | 2015-12-09 | 武汉理工大学 | 苯并呋喃并[2,3-c]吡啶化合物及其合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3522959A1 (de) * | 1985-06-27 | 1987-01-08 | Merck Patent Gmbh | Indolderivate |
| US4673680A (en) * | 1985-09-18 | 1987-06-16 | Pendleton Robert G | α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility |
| EP0339959A3 (en) * | 1988-04-27 | 1991-03-20 | Glaxo Group Limited | Lactam derivatives |
| US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
| ES2168682T3 (es) * | 1996-12-06 | 2002-06-16 | Abbott Lab | Compuestos alfa-1 adrenergicos a base de benzopiranopirrol y de benzopiranopiridina. |
| UA52681C2 (uk) * | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
| UA69420C2 (uk) * | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ |
-
1999
- 1999-10-01 NZ NZ510116A patent/NZ510116A/xx unknown
- 1999-10-01 ES ES99950628T patent/ES2222735T3/es not_active Expired - Lifetime
- 1999-10-01 EE EEP200100210A patent/EE04680B1/xx not_active IP Right Cessation
- 1999-10-01 JP JP2000574535A patent/JP4590102B2/ja not_active Expired - Fee Related
- 1999-10-01 ID IDW20010779A patent/ID28451A/id unknown
- 1999-10-01 WO PCT/EP1999/007420 patent/WO2000020423A1/en not_active Application Discontinuation
- 1999-10-01 TR TR2001/00953T patent/TR200100953T2/xx unknown
- 1999-10-01 TW TW088116897A patent/TWI244485B/zh not_active IP Right Cessation
- 1999-10-01 US US09/806,587 patent/US6352999B1/en not_active Expired - Lifetime
- 1999-10-01 CZ CZ20011105A patent/CZ20011105A3/cs unknown
- 1999-10-01 CA CA2346082A patent/CA2346082C/en not_active Expired - Fee Related
- 1999-10-01 PL PL99347179A patent/PL347179A1/xx not_active Application Discontinuation
- 1999-10-01 UA UA2001032000A patent/UA70961C2/uk unknown
- 1999-10-01 BR BR9913108-0A patent/BR9913108A/pt not_active Application Discontinuation
- 1999-10-01 IL IL14244499A patent/IL142444A0/xx active IP Right Grant
- 1999-10-01 AU AU63342/99A patent/AU759199B2/en not_active Ceased
- 1999-10-01 EP EP99950628A patent/EP1119570B1/en not_active Expired - Lifetime
- 1999-10-01 DE DE69918148T patent/DE69918148T2/de not_active Expired - Lifetime
- 1999-10-01 AT AT99950628T patent/ATE269337T1/de not_active IP Right Cessation
- 1999-10-01 RU RU2001111811/04A patent/RU2226194C2/ru not_active IP Right Cessation
- 1999-10-01 SK SK433-2001A patent/SK285386B6/sk unknown
- 1999-10-01 CN CN998116688A patent/CN1131868C/zh not_active Expired - Fee Related
- 1999-10-01 HU HU0103749A patent/HUP0103749A3/hu unknown
- 1999-10-01 KR KR1020017000443A patent/KR20010071844A/ko active Search and Examination
- 1999-10-05 AR ARP990105041A patent/AR023679A1/es active IP Right Grant
-
2001
- 2001-03-12 BG BG105334A patent/BG64871B1/bg unknown
- 2001-03-20 NO NO20011402A patent/NO20011402D0/no not_active Application Discontinuation
- 2001-04-04 IL IL142444A patent/IL142444A/en not_active IP Right Cessation
- 2001-12-10 HK HK01108630A patent/HK1038009A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |