AR021924A1 - BENZISOXAZOLES Y FENONAS COMO ALFA-2-ANTAGONISTAS , UN PROCESO PARA SU PREPARACIoN , COMPOSICIONES FARMACÉUTICAS Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UN MEDICAMENTO. - Google Patents
BENZISOXAZOLES Y FENONAS COMO ALFA-2-ANTAGONISTAS , UN PROCESO PARA SU PREPARACIoN , COMPOSICIONES FARMACÉUTICAS Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UN MEDICAMENTO.Info
- Publication number
- AR021924A1 AR021924A1 ARP990106577A ARP990106577A AR021924A1 AR 021924 A1 AR021924 A1 AR 021924A1 AR P990106577 A ARP990106577 A AR P990106577A AR P990106577 A ARP990106577 A AR P990106577A AR 021924 A1 AR021924 A1 AR 021924A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- preparation
- benzisoxazoles
- phenones
- alfa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se relaciona con compuestos de formula (1) las formas N-oxido, las sales de adicion farmacéuticamente aceptables y las formasestereoquímicamente isoméricas de los mismos, en donde Alk es alcanodiilo C5-12; n es 1 o 2; p es 1 yq es 2; o p es 2 y q es 1; X es -O-, -S-,-S(=O)-,-S(=O)2- o NR2 cada R1 es independientemente hidrogeno, halogeno, alquilo C1-6, nitro, hidroxi o alquiloxi C1-4; R2 es hidrogeno, alquilo C1-6, arilo o alquiloC1-6 sustituido con arilo; arilo esfenilo o fenilo sustituido con un halogeno o alquilo C1-6; D es un 3-bencisoxazolilo o benzofenona opcionalmente sustituida; que tienen actividad antagonista de alfa2-receptores adrenérgicos centrales. Además se relaciona con su preparacion, con suuso far macéutico y concomposiciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204358 | 1998-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021924A1 true AR021924A1 (es) | 2002-09-04 |
Family
ID=8234508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106577A AR021924A1 (es) | 1998-12-21 | 1999-12-20 | BENZISOXAZOLES Y FENONAS COMO ALFA-2-ANTAGONISTAS , UN PROCESO PARA SU PREPARACIoN , COMPOSICIONES FARMACÉUTICAS Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UN MEDICAMENTO. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6576640B1 (es) |
| EP (1) | EP1140934B1 (es) |
| JP (1) | JP4717216B2 (es) |
| KR (2) | KR100657540B1 (es) |
| CN (1) | CN1154646C (es) |
| AR (1) | AR021924A1 (es) |
| AT (1) | ATE251622T1 (es) |
| AU (1) | AU765751B2 (es) |
| BG (1) | BG65162B1 (es) |
| BR (1) | BR9916427A (es) |
| CA (1) | CA2355716C (es) |
| CZ (1) | CZ294532B6 (es) |
| DE (1) | DE69911995T2 (es) |
| EA (1) | EA003606B1 (es) |
| EE (1) | EE200100329A (es) |
| ES (1) | ES2209553T3 (es) |
| HK (1) | HK1045686B (es) |
| HR (1) | HRP20010444A2 (es) |
| HU (1) | HUP0104812A3 (es) |
| ID (1) | ID28967A (es) |
| IL (2) | IL143830A0 (es) |
| NO (1) | NO317892B1 (es) |
| NZ (1) | NZ511411A (es) |
| PL (1) | PL196958B1 (es) |
| SK (1) | SK285560B6 (es) |
| TR (1) | TR200101813T2 (es) |
| TW (1) | TWI229673B (es) |
| UA (1) | UA71938C2 (es) |
| WO (1) | WO2000037466A1 (es) |
| ZA (1) | ZA200105067B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04000036A (es) * | 2001-07-05 | 2004-05-21 | Upjohn Co | Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht. |
| WO2003082825A1 (en) * | 2002-04-03 | 2003-10-09 | Orion Corporation | Use of an alfa2-adrenoreceptor antagonist for cns-related diseases |
| AU2005233456A1 (en) * | 2004-04-12 | 2005-10-27 | Taisho Pharmaceutical Co., Ltd. | Cyclic amine compound |
| CN101268075A (zh) * | 2005-07-28 | 2008-09-17 | 百时美施贵宝公司 | 作为5-羟色胺受体激动剂和拮抗剂的取代的四氢-1h吡啶并[4,3,b]吲哚 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3419568A (en) * | 1966-12-07 | 1968-12-31 | Abbott Lab | Derivatives of 1,2,3,4-tetrahydro-5h-pyrido[4,3b]indoles |
| US3382250A (en) * | 1966-12-07 | 1968-05-07 | Abbott Lab | Aroylalkyl derivatives of 1, 2, 3, 4-tetrahydro-5h-pyrido[4, 3b]indoles |
| US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
| JPS4729395U (es) * | 1971-04-26 | 1972-12-04 | ||
| AR207799A1 (es) * | 1974-04-01 | 1976-10-29 | Pfizer | Procedimiento para preparar azaciclo(3,4-a)-n-fenilindoles-2-substituidos |
| US4001263A (en) * | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
| US4224329A (en) * | 1979-01-23 | 1980-09-23 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| FR2570701B1 (fr) | 1984-09-27 | 1987-05-22 | Synthelabo | Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique |
| DE3522959A1 (de) * | 1985-06-27 | 1987-01-08 | Merck Patent Gmbh | Indolderivate |
| EP0339959A3 (en) | 1988-04-27 | 1991-03-20 | Glaxo Group Limited | Lactam derivatives |
| WO1994008040A1 (en) * | 1992-09-25 | 1994-04-14 | Synaptic Pharmaceutical Corporation | Dna encoding human alpha 1 adrenergic receptors and uses thereof |
| US5403847A (en) | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| US5508306A (en) * | 1992-11-13 | 1996-04-16 | Synaptic Pharmaceutical Corporation | Aromatic amine derivatives |
| UA52681C2 (uk) * | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
-
1999
- 1999-12-14 BR BR9916427-2A patent/BR9916427A/pt not_active Application Discontinuation
- 1999-12-14 KR KR1020017004946A patent/KR100657540B1/ko not_active IP Right Cessation
- 1999-12-14 EA EA200100709A patent/EA003606B1/ru not_active IP Right Cessation
- 1999-12-14 CZ CZ20012120A patent/CZ294532B6/cs not_active IP Right Cessation
- 1999-12-14 WO PCT/EP1999/010054 patent/WO2000037466A1/en not_active Application Discontinuation
- 1999-12-14 CN CNB998147095A patent/CN1154646C/zh not_active Expired - Fee Related
- 1999-12-14 EE EEP200100329A patent/EE200100329A/xx unknown
- 1999-12-14 NZ NZ511411A patent/NZ511411A/xx unknown
- 1999-12-14 KR KR1020067015507A patent/KR20060093139A/ko not_active Application Discontinuation
- 1999-12-14 JP JP2000589537A patent/JP4717216B2/ja not_active Expired - Fee Related
- 1999-12-14 EP EP99967955A patent/EP1140934B1/en not_active Expired - Lifetime
- 1999-12-14 AU AU24327/00A patent/AU765751B2/en not_active Ceased
- 1999-12-14 CA CA2355716A patent/CA2355716C/en not_active Expired - Fee Related
- 1999-12-14 TR TR2001/01813T patent/TR200101813T2/xx unknown
- 1999-12-14 IL IL14383099A patent/IL143830A0/xx active IP Right Grant
- 1999-12-14 AT AT99967955T patent/ATE251622T1/de not_active IP Right Cessation
- 1999-12-14 SK SK858-2001A patent/SK285560B6/sk unknown
- 1999-12-14 HU HU0104812A patent/HUP0104812A3/hu unknown
- 1999-12-14 ID IDW00200101335A patent/ID28967A/id unknown
- 1999-12-14 UA UA2001064352A patent/UA71938C2/uk unknown
- 1999-12-14 US US09/868,756 patent/US6576640B1/en not_active Expired - Lifetime
- 1999-12-14 DE DE69911995T patent/DE69911995T2/de not_active Expired - Lifetime
- 1999-12-14 PL PL348421A patent/PL196958B1/pl unknown
- 1999-12-14 ES ES99967955T patent/ES2209553T3/es not_active Expired - Lifetime
- 1999-12-16 TW TW088122067A patent/TWI229673B/zh not_active IP Right Cessation
- 1999-12-20 AR ARP990106577A patent/AR021924A1/es active IP Right Grant
-
2001
- 2001-05-18 BG BG105521A patent/BG65162B1/bg unknown
- 2001-06-06 NO NO20012783A patent/NO317892B1/no unknown
- 2001-06-14 HR HR20010444A patent/HRP20010444A2/hr not_active Application Discontinuation
- 2001-06-19 IL IL143830A patent/IL143830A/en not_active IP Right Cessation
- 2001-06-20 ZA ZA200105067A patent/ZA200105067B/en unknown
-
2002
- 2002-07-09 HK HK02105098.8A patent/HK1045686B/zh not_active IP Right Cessation
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| AR021924A1 (es) | BENZISOXAZOLES Y FENONAS COMO ALFA-2-ANTAGONISTAS , UN PROCESO PARA SU PREPARACIoN , COMPOSICIONES FARMACÉUTICAS Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UN MEDICAMENTO. |
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| Date | Code | Title | Description |
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| FG | Grant, registration |