[go: up one dir, main page]

AR019178A1 - Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr - Google Patents

Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr

Info

Publication number
AR019178A1
AR019178A1 ARP990103129A ARP990103129A AR019178A1 AR 019178 A1 AR019178 A1 AR 019178A1 AR P990103129 A ARP990103129 A AR P990103129A AR P990103129 A ARP990103129 A AR P990103129A AR 019178 A1 AR019178 A1 AR 019178A1
Authority
AR
Argentina
Prior art keywords
alkyl
compounds
thiophen
furan
phenyl
Prior art date
Application number
ARP990103129A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR019178A1 publication Critical patent/AR019178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se trata de compuestos de formula I, utiles para inhibir la absorcion de serotonina, antagonizar el receptor 5-HT1a y antagonizar el receptor 5-HT2a,mediante la administracion de personas que refieran dicho tratamiento, caracterizado porquecantidade s eficaces de un compuesto de formula I en la que X esO, S, NR, S(=O) o S(=O)2; Y es -C(=O)-, -CH(OH)-, CH2, -C(=NOR), CHNR7R, S, SO o SO2; = representa un enlace sencillo o doble; n es 1, 2, 3 o 4; R es H oalquilo C1-6; cada uno de R1a,R1b,R1c y R 2 es, independientemente, H, F, Cl, Br, I, OH, alquilo C1-6, alcoxi C1-6, halo-alquilo C1-6, alquiltio C1-6,fenilo,NO2,-NR7R8,-C(=O)NR78R8,-NR7C(=O)R8, CN o fenilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuestopor F, Cl, B r, I, OH,alquiloC1-6,alcoxi C1-6,halo-alquilo C1-6,alquiltio C1-6, fenilo, NO2, NH2 o CN; R3 es H, OH, hidroxi-alquilo C1-6, alquilo C1-6, alcoxi C1-6 o alquiltio C1-6;R4 esarilo,heterociclo, cicloalquilo C3-8, arilo sustituido con 1 a3 sustituyente s seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-6,alcoxi C1-6,haloalquilo C1-6, alquiltio C1-6, fenilo, NO2, NH2 o CN; o heterociclo sustituido con 1 a 3 sustituyentes seleccionados entre el grupocompuestopor F, Cl, Br, I, OH, alquilo C1-6, alcoxi C1-6, halo-alquilo C1-6, alquiltio C1-6, fenilo, NO2, NH2 o CN; R5 es arilo, heterociclo, cicloalquilo C3-6, arilosustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F,Cl, Br, I, OH, alquilo C1-6, a lcoxi C1-6, hidroxi-alquilo C1-6, halo-alquilo C1-6, fenilo, NO2, NH2 o CN; o heterociclo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquiloC1-6, alcoxi C1-6,hidroxi-alquilo C1-6, alquiltio C1-6, fenilo, NO2 o CN; cada uno de R6a y R6b es, independientemente, H o alquilo C1-3; cada unode R7 y R8 es independientemente, H, alquilo C1-6, arilo o arilo sustituido con 1 a 3 sustituyentes seleccionados entreel grupo compuesto por F, Cl, Br, I,OH, alquilo C1-C6, alcoxi C1-6, halo-alquilo C1-6, alquiltio C1-6, fenilo, NO2, NH2 o CN; y las sales farmacéuticamente del mismo. También se proponen
ARP990103129A 1998-06-30 1999-06-29 Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr AR019178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9124198P 1998-06-30 1998-06-30

Publications (1)

Publication Number Publication Date
AR019178A1 true AR019178A1 (es) 2001-12-26

Family

ID=22226762

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103129A AR019178A1 (es) 1998-06-30 1999-06-29 Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr

Country Status (12)

Country Link
US (1) US6436964B1 (es)
EP (1) EP0982304B1 (es)
JP (1) JP2002519323A (es)
AR (1) AR019178A1 (es)
AT (1) ATE225345T1 (es)
AU (1) AU4726699A (es)
CA (1) CA2336117A1 (es)
CO (1) CO5080791A1 (es)
DE (1) DE69903239T2 (es)
ES (1) ES2181366T3 (es)
PE (1) PE20000763A1 (es)
WO (1) WO2000000198A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4727799A (en) 1998-06-30 2000-01-17 Eli Lilly And Company Azepine derivatives having effects on serotonin related systems
KR20020015068A (ko) * 1999-06-29 2002-02-27 피터 지. 스트링거 치환된 피페리딘-4-온의 제조 방법
WO2001000620A2 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Preparation of 7-substituted benzothiophenes
ES2209951T3 (es) * 1999-07-29 2004-07-01 Eli Lilly And Company Benzofuranos serotoninergicos.
WO2001009126A1 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzothiophenes
US6881733B1 (en) 1999-07-29 2005-04-19 Eli Lilly And Company Serotonergic benzofurans
US6828332B1 (en) 1999-09-29 2004-12-07 Eli Lilly And Company Piperidine derivatives as reuptake inhibitors
AU7329700A (en) * 1999-09-29 2001-04-30 Eli Lilly And Company Piperidine derivatives as serotonine reuptake inhibitors
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
ITMI20021329A1 (it) * 2002-06-14 2003-12-15 Recordati Chem Pharm Nuove ossialchilammine sostituite
WO2004019892A2 (en) * 2002-08-30 2004-03-11 Watson Pharmaceuticals, Inc. Drug delivery system for treating urinary incontinence
NZ537982A (en) 2002-09-17 2007-05-31 Hoffmann La Roche 2,7-substituted indoles and their use as 5-HT6 modulators
AU2003267063B2 (en) 2002-09-17 2009-08-06 F. Hoffman-La Roche Ag 2,4-substituted indoles and their use as 5-HT6 modulators
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
MX2009001875A (es) 2006-08-21 2009-03-02 Genentech Inc Compuestos de aza-benzotiofenilo y metodos de uso de los mismos.
DE112015006213A5 (de) 2015-02-24 2017-11-16 MSO Meßtechnik und Ortung GmbH Verfahren zur Messung des Erntegutmassestroms am Feldhäcksler
NL1041393B1 (en) 2015-07-07 2017-01-30 Kessener B V Method and device providing a liquid display.
DE102016002899B4 (de) 2016-03-09 2020-03-12 Johannes Kraus Feuerraum mit verbessertem Ausbrand
DE202016005695U1 (de) 2016-09-12 2016-10-04 Jürgen Raudis Seifenabstandhalter zum Trocknen fester Seifen mit Seifenabtropfbehälter

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006524A1 (de) 1978-06-22 1980-01-09 Ciba-Geigy Ag Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
GB2056435A (en) 1979-06-26 1981-03-18 Ciba Geigy Ag Novel Tetrahydropyridine and Piperidine Substituted Benzofuranes and Related Compounds
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
EP0664801A1 (en) * 1992-08-05 1995-08-02 JOHN WYETH & BROTHER LIMITED Amide derivatives
DK148392D0 (da) 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
CA2250347C (en) * 1996-03-29 2006-02-21 Duphar International Research B.V. Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors
WO1999005140A1 (en) * 1997-07-25 1999-02-04 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ES2181366T3 (es) 2003-02-16
ATE225345T1 (de) 2002-10-15
AU4726699A (en) 2000-01-17
EP0982304B1 (en) 2002-10-02
PE20000763A1 (es) 2000-08-30
WO2000000198A1 (en) 2000-01-06
US6436964B1 (en) 2002-08-20
CO5080791A1 (es) 2001-09-25
DE69903239D1 (de) 2002-11-07
WO2000000198A8 (en) 2000-03-23
EP0982304A1 (en) 2000-03-01
DE69903239T2 (de) 2003-09-11
JP2002519323A (ja) 2002-07-02
CA2336117A1 (en) 2000-01-06

Similar Documents

Publication Publication Date Title
AR019178A1 (es) Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr
ES2147223T3 (es) Derivados de indol como agonistas de tipo 5-ht1.
AR058287A1 (es) Derivados de isoquinolina y composicion farmaceutica
DK0628311T3 (da) Xanthinderivater som antidepressive midler
CO5580747A2 (es) Derivados e intermediarios de n-adamantilmetilo como composiciones farmaceuticas y procesos para su preparacion
AR036659A1 (es) Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos
ATE247654T1 (de) Neue heterozyklische verbindungen
NO902214D0 (no) Fremgangsmaate for fremstilling av n-(aryloksyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner og deres anvendelse som medikamenter.
AR035234A1 (es) Aril y biaril-piperidinas con actividad moduladora mch, metodo para preparar dichos compuestos, composiciones farmaceuticas, metodo para preparar las composiciones farmaceuticas y el uso de dichos compuestos para la manufactura de un medicamento
AR035431A1 (es) 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas, un metodo para su sintesis, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos
YU108791A (sh) Pirazolopirimidinon antianginalna jedinjenja
AR037907A1 (es) Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6
SE8501452D0 (sv) Nya 4-aroylimidazol-2-oner
CO5590924A2 (es) Derivados de indolilalquilamina como ligandos de 5- hidroxitriptamina-6
HUT68721A (en) Benzofuran and benzizoxazole derivatives, pharmaceutical composition containing said compounds as active agent and process for preparing them
DE69208408D1 (de) Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung
EP1304324A4 (en) SEROTONIN RECOVERY INHIBITORS
AR030239A1 (es) Fta lidas substituidas, un procedimiento para su preparacion y composiciones farmaceuticas que contienen las mismas
NO172893C (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive cefem-forbindelser
PE20020599A1 (es) Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d
MX174210B (es) Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
ATE135695T1 (de) 4-pyrimidinonderivate, ihre herstellung und ihre anwendung in der therapie
DE68911371D1 (de) 2,2-Disubstituierte Benzopyran-Leukotrien-D4-Antagonisten.
ES2099180T3 (es) Derivados del benzopirano y procedimientos para su preparacion.
PT92591A (pt) Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem