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ES2181366T3 - Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina. - Google Patents

Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina.

Info

Publication number
ES2181366T3
ES2181366T3 ES99305095T ES99305095T ES2181366T3 ES 2181366 T3 ES2181366 T3 ES 2181366T3 ES 99305095 T ES99305095 T ES 99305095T ES 99305095 T ES99305095 T ES 99305095T ES 2181366 T3 ES2181366 T3 ES 2181366T3
Authority
ES
Spain
Prior art keywords
serotonin
effects
piperidine derivatives
systems related
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99305095T
Other languages
English (en)
Inventor
Daniel Timothy Kohlman
Sidney Xi Liang
Yao-Chang Xu
Larry Wayne Hertel
David Taiwai Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2181366T3 publication Critical patent/ES2181366T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula I y a un procedimiento de inhibición de la absorción de serotonina, que antagoniza el receptor 5-HT1A y el receptor 5-HT2A que comprende la administración de una cantidad eficaz de un compuesto de fórmula I. a un sujeto que necesite dicho tratamiento.
ES99305095T 1998-06-30 1999-06-29 Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina. Expired - Lifetime ES2181366T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9124198P 1998-06-30 1998-06-30

Publications (1)

Publication Number Publication Date
ES2181366T3 true ES2181366T3 (es) 2003-02-16

Family

ID=22226762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99305095T Expired - Lifetime ES2181366T3 (es) 1998-06-30 1999-06-29 Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina.

Country Status (12)

Country Link
US (1) US6436964B1 (es)
EP (1) EP0982304B1 (es)
JP (1) JP2002519323A (es)
AR (1) AR019178A1 (es)
AT (1) ATE225345T1 (es)
AU (1) AU4726699A (es)
CA (1) CA2336117A1 (es)
CO (1) CO5080791A1 (es)
DE (1) DE69903239T2 (es)
ES (1) ES2181366T3 (es)
PE (1) PE20000763A1 (es)
WO (1) WO2000000198A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4727799A (en) 1998-06-30 2000-01-17 Eli Lilly And Company Azepine derivatives having effects on serotonin related systems
KR20020015068A (ko) * 1999-06-29 2002-02-27 피터 지. 스트링거 치환된 피페리딘-4-온의 제조 방법
WO2001000620A2 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Preparation of 7-substituted benzothiophenes
ES2209951T3 (es) * 1999-07-29 2004-07-01 Eli Lilly And Company Benzofuranos serotoninergicos.
WO2001009126A1 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzothiophenes
US6881733B1 (en) 1999-07-29 2005-04-19 Eli Lilly And Company Serotonergic benzofurans
US6828332B1 (en) 1999-09-29 2004-12-07 Eli Lilly And Company Piperidine derivatives as reuptake inhibitors
AU7329700A (en) * 1999-09-29 2001-04-30 Eli Lilly And Company Piperidine derivatives as serotonine reuptake inhibitors
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
ITMI20021329A1 (it) * 2002-06-14 2003-12-15 Recordati Chem Pharm Nuove ossialchilammine sostituite
WO2004019892A2 (en) * 2002-08-30 2004-03-11 Watson Pharmaceuticals, Inc. Drug delivery system for treating urinary incontinence
NZ537982A (en) 2002-09-17 2007-05-31 Hoffmann La Roche 2,7-substituted indoles and their use as 5-HT6 modulators
AU2003267063B2 (en) 2002-09-17 2009-08-06 F. Hoffman-La Roche Ag 2,4-substituted indoles and their use as 5-HT6 modulators
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
MX2009001875A (es) 2006-08-21 2009-03-02 Genentech Inc Compuestos de aza-benzotiofenilo y metodos de uso de los mismos.
DE112015006213A5 (de) 2015-02-24 2017-11-16 MSO Meßtechnik und Ortung GmbH Verfahren zur Messung des Erntegutmassestroms am Feldhäcksler
NL1041393B1 (en) 2015-07-07 2017-01-30 Kessener B V Method and device providing a liquid display.
DE102016002899B4 (de) 2016-03-09 2020-03-12 Johannes Kraus Feuerraum mit verbessertem Ausbrand
DE202016005695U1 (de) 2016-09-12 2016-10-04 Jürgen Raudis Seifenabstandhalter zum Trocknen fester Seifen mit Seifenabtropfbehälter

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006524A1 (de) 1978-06-22 1980-01-09 Ciba-Geigy Ag Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
GB2056435A (en) 1979-06-26 1981-03-18 Ciba Geigy Ag Novel Tetrahydropyridine and Piperidine Substituted Benzofuranes and Related Compounds
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
EP0664801A1 (en) * 1992-08-05 1995-08-02 JOHN WYETH & BROTHER LIMITED Amide derivatives
DK148392D0 (da) 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
CA2250347C (en) * 1996-03-29 2006-02-21 Duphar International Research B.V. Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors
WO1999005140A1 (en) * 1997-07-25 1999-02-04 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AR019178A1 (es) 2001-12-26
ATE225345T1 (de) 2002-10-15
AU4726699A (en) 2000-01-17
EP0982304B1 (en) 2002-10-02
PE20000763A1 (es) 2000-08-30
WO2000000198A1 (en) 2000-01-06
US6436964B1 (en) 2002-08-20
CO5080791A1 (es) 2001-09-25
DE69903239D1 (de) 2002-11-07
WO2000000198A8 (en) 2000-03-23
EP0982304A1 (en) 2000-03-01
DE69903239T2 (de) 2003-09-11
JP2002519323A (ja) 2002-07-02
CA2336117A1 (en) 2000-01-06

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