AR018767A1 - Derivados de beta-carbolina hipnoticos, proceso para su preparacion y medicamentos - Google Patents
Derivados de beta-carbolina hipnoticos, proceso para su preparacion y medicamentosInfo
- Publication number
- AR018767A1 AR018767A1 ARP990101166A ARP990101166A AR018767A1 AR 018767 A1 AR018767 A1 AR 018767A1 AR P990101166 A ARP990101166 A AR P990101166A AR P990101166 A ARP990101166 A AR P990101166A AR 018767 A1 AR018767 A1 AR 018767A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- groups
- cycloalkyl
- hydrogen atom
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Derivados de beta-carbolina de la formula general (I) (I y I), en las X representa un radical divalente de la formula (II); R1, R2, R3 y R4representan, independientemente entre sí, un átomo de hidrogeno, un radical hidroxilo, un alquilo inferior, unalcoxilo inferior, un ariloxilo, unradical halo o nitro o una cadena alifática no saturada, alquilcarbonilo inferior, alquilcarboniloxilo inferior, carboxilo; pudiendo estos gruposestar opcionalmente sustituidos. R5 representa un átomo de hidrogeno,un alquilo inferior, cicloalquilo, arilo, aralquilo inferior, alcoxilo inferior,alquilcarbonilo inferior, haloalquilcarbonilo inferior, alquiloxicarbonilo inferior, amino; pudiendo estos grupos estar opcionalmente sustituidos.R6, R7, R9, R10, R12,R1 3, R14 y R15 representan, independientemente entre sí, un átomo de hidrogeno, un radical alquilo inferior, un cicloalquiloinferior, haloalquilo inferior, perhaloalquilo inferior, arilo, aralquilo, alcoxilo inferior, cicloalcoxilo inferior, mono opol ihaloalcoxilo,ariloxilo, aralquiloxilo, hidroxialquilo, alquiloxialquilo, alquiltio inferior, cicloalquiltio inferior; pudiendo estos grupos estar opcionalmentesustituidos. R8 representa un alquilo inferior, un cicloalquilo inferior,hidroxialquilo, alquiloxialquilo, haloalquilo inferior, perhaloalquilo inferior;pudiendo estos grupos estar opcionalmente sustituidos. R11 representa un átomo de oxígeno o un átomo de azufre, opcionalmente sustituidos, un procesopara su preparaciony medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/042,990 US6048868A (en) | 1994-09-14 | 1998-03-17 | Melatonin-antagonist β-carboline derivatives and analogues thereof containing naphthalenic structure, process for their preparation and their use as medicinal products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018767A1 true AR018767A1 (es) | 2001-12-12 |
Family
ID=21924862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101166A AR018767A1 (es) | 1998-03-17 | 1999-03-17 | Derivados de beta-carbolina hipnoticos, proceso para su preparacion y medicamentos |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1064284B1 (es) |
| JP (1) | JP4333036B2 (es) |
| CN (1) | CN1115342C (es) |
| AR (1) | AR018767A1 (es) |
| AT (1) | ATE215087T1 (es) |
| AU (1) | AU752364B2 (es) |
| BG (1) | BG63973B1 (es) |
| BR (1) | BR9908833A (es) |
| CA (1) | CA2324270A1 (es) |
| DE (1) | DE69901098T2 (es) |
| DK (1) | DK1064284T3 (es) |
| ES (1) | ES2174632T3 (es) |
| HU (1) | HUP0101234A3 (es) |
| IL (1) | IL138442A (es) |
| IS (1) | IS2199B (es) |
| NO (1) | NO317296B1 (es) |
| NZ (1) | NZ506913A (es) |
| PL (1) | PL193450B1 (es) |
| PT (1) | PT1064284E (es) |
| RU (1) | RU2210571C2 (es) |
| SK (1) | SK284387B6 (es) |
| TR (1) | TR200003596T2 (es) |
| UA (1) | UA71911C2 (es) |
| WO (1) | WO1999047521A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2824829B1 (fr) * | 2001-05-16 | 2005-06-03 | Macef | Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament |
| FR2904973A1 (fr) * | 2006-08-18 | 2008-02-22 | Fourtillan Snc | Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique. |
| FR2916200A1 (fr) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique |
| NZ586120A (en) | 2008-01-11 | 2012-07-27 | Albany Molecular Res Inc | (1-azinone) -substituted pyridoindoles as mch antagonists |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| FI130627B (en) * | 2021-03-31 | 2023-12-18 | Equinorm Ltd | Novel heterocyclic compounds and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283343A (en) * | 1987-08-17 | 1994-02-01 | Whitby Research, Inc. | 2-aryl substituted N-acetyltryptamines and process of preparing such |
| FR2724384B1 (fr) * | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
-
1999
- 1999-03-17 NZ NZ506913A patent/NZ506913A/en unknown
- 1999-03-17 JP JP2000536716A patent/JP4333036B2/ja not_active Expired - Fee Related
- 1999-03-17 ES ES99939844T patent/ES2174632T3/es not_active Expired - Lifetime
- 1999-03-17 SK SK1385-2000A patent/SK284387B6/sk not_active IP Right Cessation
- 1999-03-17 IL IL138442A patent/IL138442A/en not_active IP Right Cessation
- 1999-03-17 HU HU0101234A patent/HUP0101234A3/hu unknown
- 1999-03-17 PT PT99939844T patent/PT1064284E/pt unknown
- 1999-03-17 TR TR2000/03596T patent/TR200003596T2/xx unknown
- 1999-03-17 DE DE69901098T patent/DE69901098T2/de not_active Expired - Lifetime
- 1999-03-17 RU RU2000126288/04A patent/RU2210571C2/ru not_active IP Right Cessation
- 1999-03-17 PL PL99342929A patent/PL193450B1/pl not_active IP Right Cessation
- 1999-03-17 UA UA2000105839A patent/UA71911C2/uk unknown
- 1999-03-17 BR BR9908833-9A patent/BR9908833A/pt not_active Application Discontinuation
- 1999-03-17 DK DK99939844T patent/DK1064284T3/da active
- 1999-03-17 AT AT99939844T patent/ATE215087T1/de not_active IP Right Cessation
- 1999-03-17 CN CN99805687A patent/CN1115342C/zh not_active Expired - Fee Related
- 1999-03-17 AU AU32707/99A patent/AU752364B2/en not_active Ceased
- 1999-03-17 EP EP99939844A patent/EP1064284B1/en not_active Expired - Lifetime
- 1999-03-17 WO PCT/IB1999/000494 patent/WO1999047521A1/en active IP Right Grant
- 1999-03-17 AR ARP990101166A patent/AR018767A1/es active IP Right Grant
- 1999-03-17 CA CA002324270A patent/CA2324270A1/en not_active Abandoned
-
2000
- 2000-09-12 IS IS5627A patent/IS2199B/is unknown
- 2000-09-14 BG BG104768A patent/BG63973B1/bg unknown
- 2000-09-15 NO NO20004638A patent/NO317296B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |