DK0691951T3 - Fremgangsmåde til fremstilling af beta-phenylisoserinderivater - Google Patents
Fremgangsmåde til fremstilling af beta-phenylisoserinderivaterInfo
- Publication number
- DK0691951T3 DK0691951T3 DK94911225T DK94911225T DK0691951T3 DK 0691951 T3 DK0691951 T3 DK 0691951T3 DK 94911225 T DK94911225 T DK 94911225T DK 94911225 T DK94911225 T DK 94911225T DK 0691951 T3 DK0691951 T3 DK 0691951T3
- Authority
- DK
- Denmark
- Prior art keywords
- radical
- pct
- beta
- preparation
- optionally substituted
- Prior art date
Links
- RZARFIRJROUVLM-GVHYBUMESA-N (3r)-3-amino-2-hydroxy-3-phenylpropanoic acid Chemical class OC(=O)C(O)[C@H](N)C1=CC=CC=C1 RZARFIRJROUVLM-GVHYBUMESA-N 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 alkyl radical Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9303575A FR2703353B1 (fr) | 1993-03-29 | 1993-03-29 | Procédé de préparation de dérivés de la beta-phénylisosérine. |
| PCT/FR1994/000339 WO1994022813A1 (fr) | 1993-03-29 | 1994-03-25 | PROCEDE DE PREPARATION DE DERIVES DE LA β-PHENYLISOSERINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0691951T3 true DK0691951T3 (da) | 1998-10-19 |
Family
ID=9445442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94911225T DK0691951T3 (da) | 1993-03-29 | 1994-03-25 | Fremgangsmåde til fremstilling af beta-phenylisoserinderivater |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5681970A (da) |
| EP (1) | EP0691951B1 (da) |
| JP (1) | JP3633619B2 (da) |
| AT (1) | ATE167179T1 (da) |
| CA (1) | CA2158060C (da) |
| DE (1) | DE69411000T2 (da) |
| DK (1) | DK0691951T3 (da) |
| ES (1) | ES2118394T3 (da) |
| FR (1) | FR2703353B1 (da) |
| WO (1) | WO1994022813A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE253563T1 (de) * | 1993-02-05 | 2003-11-15 | Bryn Mawr College | Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten |
| KR100225534B1 (ko) * | 1996-03-19 | 1999-10-15 | 정지석 | (2R,3S)-베타-페닐이소세린 유도체의 입체선택적 제조방법[Storcospecific process for preparing(2R,3S)-β0phenylisoserine] |
| US6025516A (en) * | 1998-10-14 | 2000-02-15 | Chiragene, Inc. | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes |
| US6847778B1 (en) | 1999-03-30 | 2005-01-25 | Tivo, Inc. | Multimedia visual progress indication system |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US20110223154A1 (en) | 2008-05-12 | 2011-09-15 | University Of South Florida | Compositions including triciribine and methods of use thereof |
| US20100028339A1 (en) * | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20100009928A1 (en) * | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009929A1 (en) * | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| AU2005228410A1 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| EP2300055A1 (en) | 2008-05-12 | 2011-03-30 | University Of South Florida | Anticancer combination therapy including triciribine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL95436A (en) * | 1989-08-23 | 1996-07-23 | Centre Nat Rech Scient | Process for preparing the history of phenylisosarine |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
-
1993
- 1993-03-29 FR FR9303575A patent/FR2703353B1/fr not_active Expired - Lifetime
-
1994
- 1994-03-25 JP JP52174294A patent/JP3633619B2/ja not_active Expired - Lifetime
- 1994-03-25 EP EP94911225A patent/EP0691951B1/fr not_active Expired - Lifetime
- 1994-03-25 CA CA002158060A patent/CA2158060C/fr not_active Expired - Lifetime
- 1994-03-25 ES ES94911225T patent/ES2118394T3/es not_active Expired - Lifetime
- 1994-03-25 US US08/525,786 patent/US5681970A/en not_active Expired - Lifetime
- 1994-03-25 WO PCT/FR1994/000339 patent/WO1994022813A1/fr active IP Right Grant
- 1994-03-25 AT AT94911225T patent/ATE167179T1/de active
- 1994-03-25 DE DE69411000T patent/DE69411000T2/de not_active Expired - Lifetime
- 1994-03-25 DK DK94911225T patent/DK0691951T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0691951B1 (fr) | 1998-06-10 |
| CA2158060C (fr) | 2006-11-21 |
| DE69411000D1 (de) | 1998-07-16 |
| ATE167179T1 (de) | 1998-06-15 |
| FR2703353A1 (fr) | 1994-10-07 |
| JP3633619B2 (ja) | 2005-03-30 |
| DE69411000T2 (de) | 1998-12-03 |
| FR2703353B1 (fr) | 1995-05-05 |
| US5681970A (en) | 1997-10-28 |
| ES2118394T3 (es) | 1998-09-16 |
| CA2158060A1 (fr) | 1994-10-13 |
| EP0691951A1 (fr) | 1996-01-17 |
| JPH08508281A (ja) | 1996-09-03 |
| WO1994022813A1 (fr) | 1994-10-13 |
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