AR015521A1 - Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen. - Google Patents
Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen.Info
- Publication number
- AR015521A1 AR015521A1 ARP990100676A ARP990100676A AR015521A1 AR 015521 A1 AR015521 A1 AR 015521A1 AR P990100676 A ARP990100676 A AR P990100676A AR P990100676 A ARP990100676 A AR P990100676A AR 015521 A1 AR015521 A1 AR 015521A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- independently selected
- substituted
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ftalimido arilpiperazinas de la formula I en donde: R1 es hidrogeno, halogeno, alcoxi C1-5, hidroxilo o alquilo C1-5, R2 es alquilo C1-6, alquilo C1-6sustituido donde los sustituyentes de alquilo son independientemente seleccionados entre uno o másh alogenos, fenilo, fenilo sustituido donde los sustituyentesde fenilo son independientemente seleccionados entre uno o más miembros del grupo que consiste de alquilo C1-5, alcoxi C1-5 y trihaloalquiloC1-5, fenilalquiloC1-5, o fenilalquilo C1-5sustitu ido donde los sustituyentes de fenilo se seleccionan independientemente entre uno o más miembros del grupo que consiste dealquiloC1-5, halogeno, alcoxiC1-5 y trihaloalquiloC1-5; R3 es hidrogeno, hidroxi, o alcoxiC1-5, si la línea punteadaestá ausent e, o es oxígeno si la líneapunteada está presente; R4 es hidrogeno, alquilo C1-5, fenilalquilo C1-5 o fenilalquiloC1-5 sustituido, donde los sustituyentes de fenilo se seleccionanindependientemente entre uno o más miembros del grupo queconsiste de a lquilo C1-5, alcoxiC1-5 y trihaloalquiloC1-5; R5 es hidrogeno, halogeno, hidroxi,alquiloC1-8, alquiloC1-8 sustituido donde los sustituyentes de alquilo se seleccionan independientemente entre uno o más halogenos, alcoxiC1-5, amino,alquilC1-5amino, d ialquilC1-5amino, alquilC1-5carbonilo, alcoxiC1-5caarbonilo, nitrilo, o nitro; R6 es hidrogeno, halogeno, hidroxi, alquiloC1-8, alquiloC1-8sustituido donde los sustituyentes de alquilo se seleccionan independientemente entre uno omás halogenos, alco xiC1-5, amino, alquilC1-amino, dialquilC1-5amino, alquilC1-5carbonilo, alcoxiC1-5carbonilo, o nitro; A es nitrogeno o carbono; B es nitrogeno o carbono; E es nitrogeno o carbono; con la condicion de que solouno de A, B o E esnitrogeno; sales farmacé uticamente aceptables del mismo; y esteroisomeros, mezclas racémicas, así comotambién enentiomeros del mismo;composiciones farmacéuticas que los contienen, su uso para la fabricacion de un medicamento, procedimientos para supreparacion y compuestos para su exclusivouso en dichos procedimientos. Dichos compuestos inhiben selectivamente el enlace al receptor adrenérgico alfa1a, un receptor que ha sido involucrado en
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7551098P | 1998-02-20 | 1998-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015521A1 true AR015521A1 (es) | 2001-05-02 |
Family
ID=22126243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100676A AR015521A1 (es) | 1998-02-20 | 1999-02-23 | Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20020077476A1 (es) |
| EP (1) | EP1056720B1 (es) |
| JP (1) | JP2002503722A (es) |
| KR (1) | KR100608473B1 (es) |
| CN (1) | CN1172911C (es) |
| AR (1) | AR015521A1 (es) |
| AT (1) | ATE280156T1 (es) |
| AU (1) | AU766411B2 (es) |
| BR (1) | BR9908122A (es) |
| DE (1) | DE69921300T2 (es) |
| ES (1) | ES2233023T3 (es) |
| HK (1) | HK1031872A1 (es) |
| HU (1) | HUP0100704A3 (es) |
| IL (2) | IL137953A0 (es) |
| NO (1) | NO317104B1 (es) |
| NZ (1) | NZ506461A (es) |
| PL (1) | PL194649B1 (es) |
| PT (1) | PT1056720E (es) |
| TR (1) | TR200003224T2 (es) |
| WO (1) | WO1999042445A1 (es) |
| ZA (1) | ZA991319B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20010164A1 (it) * | 2001-01-30 | 2002-07-30 | Recordati Chem Pharm | Alfa 1 antagonisti selettivi a + d |
| CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
| HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
| CN105061434B (zh) * | 2015-07-30 | 2017-07-21 | 新发药业有限公司 | 一种西他列汀磷酸盐的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1382742A (en) | 1972-09-19 | 1975-02-05 | Labaz | Benzofuran derivatives and process for preparing the same |
| CH585693A5 (es) | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| HU177702B (en) | 1977-10-24 | 1981-12-28 | Noevenyvedelmi Kutato Intezet | Plant growth regulator and process for preparing the active materials |
| PT82077B (fr) * | 1985-02-26 | 1987-09-25 | Sanofi Sa | Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides |
| FR2678271B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
| ES2206928T3 (es) * | 1997-05-12 | 2004-05-16 | Ortho-Mcneil Pharmaceutical, Inc. | Piperacinas sustituidas con arilo utiles en el tratamiento de la hiperplasia benigna de prostata. |
-
1999
- 1999-02-18 ZA ZA9901319A patent/ZA991319B/xx unknown
- 1999-02-19 AU AU27765/99A patent/AU766411B2/en not_active Ceased
- 1999-02-19 KR KR1020007009159A patent/KR100608473B1/ko not_active IP Right Cessation
- 1999-02-19 HU HU0100704A patent/HUP0100704A3/hu unknown
- 1999-02-19 JP JP2000532397A patent/JP2002503722A/ja not_active Withdrawn
- 1999-02-19 PL PL99342357A patent/PL194649B1/pl not_active IP Right Cessation
- 1999-02-19 IL IL13795399A patent/IL137953A0/xx active IP Right Grant
- 1999-02-19 ES ES99908303T patent/ES2233023T3/es not_active Expired - Lifetime
- 1999-02-19 CN CNB998030260A patent/CN1172911C/zh not_active Expired - Fee Related
- 1999-02-19 DE DE69921300T patent/DE69921300T2/de not_active Expired - Fee Related
- 1999-02-19 PT PT99908303T patent/PT1056720E/pt unknown
- 1999-02-19 TR TR2000/03224T patent/TR200003224T2/xx unknown
- 1999-02-19 AT AT99908303T patent/ATE280156T1/de not_active IP Right Cessation
- 1999-02-19 NZ NZ506461A patent/NZ506461A/en unknown
- 1999-02-19 EP EP99908303A patent/EP1056720B1/en not_active Expired - Lifetime
- 1999-02-19 BR BR9908122-9A patent/BR9908122A/pt not_active Application Discontinuation
- 1999-02-19 WO PCT/US1999/003694 patent/WO1999042445A1/en active IP Right Grant
- 1999-02-23 AR ARP990100676A patent/AR015521A1/es active IP Right Grant
-
2000
- 2000-08-18 IL IL137953A patent/IL137953A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004142A patent/NO317104B1/no not_active IP Right Cessation
-
2001
- 2001-04-03 HK HK01102397A patent/HK1031872A1/xx not_active IP Right Cessation
- 2001-12-11 US US10/014,979 patent/US20020077476A1/en not_active Abandoned
-
2002
- 2002-07-29 US US10/207,473 patent/US6780994B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20020077476A1 (en) | 2002-06-20 |
| AU766411B2 (en) | 2003-10-16 |
| PT1056720E (pt) | 2005-02-28 |
| AU2776599A (en) | 1999-09-06 |
| CN1172911C (zh) | 2004-10-27 |
| US20030088099A1 (en) | 2003-05-08 |
| HUP0100704A2 (hu) | 2001-10-28 |
| IL137953A (en) | 2006-12-31 |
| NZ506461A (en) | 2003-08-29 |
| PL342357A1 (en) | 2001-06-04 |
| NO20004142L (no) | 2000-10-19 |
| PL194649B1 (pl) | 2007-06-29 |
| DE69921300D1 (de) | 2004-11-25 |
| DE69921300T2 (de) | 2006-03-09 |
| ZA991319B (en) | 2000-11-20 |
| KR20010041118A (ko) | 2001-05-15 |
| IL137953A0 (en) | 2001-10-31 |
| NO20004142D0 (no) | 2000-08-18 |
| ATE280156T1 (de) | 2004-11-15 |
| US6780994B2 (en) | 2004-08-24 |
| KR100608473B1 (ko) | 2006-08-09 |
| CN1291185A (zh) | 2001-04-11 |
| HUP0100704A3 (en) | 2002-10-28 |
| BR9908122A (pt) | 2001-11-13 |
| ES2233023T3 (es) | 2005-06-01 |
| JP2002503722A (ja) | 2002-02-05 |
| TR200003224T2 (tr) | 2001-03-21 |
| HK1031872A1 (en) | 2001-06-29 |
| EP1056720B1 (en) | 2004-10-20 |
| WO1999042445A1 (en) | 1999-08-26 |
| EP1056720A1 (en) | 2000-12-06 |
| NO317104B1 (no) | 2004-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY27952A1 (es) | Nuevos derivados de benzoimidazol útiles como agentes antiproliferativos | |
| UY28135A1 (es) | Derivados de pirimidina para el tratamiento de crecimiento celular anormal | |
| AR058546A1 (es) | Derivados de 2- adamantilurea como inhibidores selectivos de 11 beta - hsd1 | |
| AR006720A1 (es) | Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende | |
| AR040412A1 (es) | Derivados de sulfamato sustituido como anticonvulsivo | |
| AR047823A1 (es) | Derivados de 1,2,3,4-tetrahidroisoquinolina sustituida | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| ES2122646T3 (es) | Derivados de acido fosfinico con actividad inhibidora de la metalopeptidasa. | |
| PA8480101A1 (es) | Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos | |
| MXPA05007341A (es) | Derivados de 2-piperidona como agonistas de prostaglandina. | |
| AR055053A1 (es) | Compuestos indol sustituidos con actividad inhibidora de nos. composiciones farmaceuticas. | |
| AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
| AR061737A1 (es) | Compuestos derivados de pirimidina, un peoceso para su preparacion y composiciones farmaceuticas que los contienen | |
| AR042423A1 (es) | Diaril eteres como antagonistas del receptor opioide | |
| MY144461A (en) | Cinnamoyl-piperazine derivatives and their use as par-1 antagonists | |
| HRP20050390A2 (en) | Substituted benzoxazinones and uses thereof | |
| AR057464A1 (es) | Procedimiento para la preparacion de derivados de sulfonamida | |
| AR041882A1 (es) | Compuestos de imidazopiridina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| AR072336A1 (es) | Derivados de la 3-carboxipropil-aminotetralina, composiciones farmaceuticas que los contienen, procedimiento para su preparacion, intermediarios y su procedimiento de preparacion | |
| AR017072A1 (es) | Compuestos derivados de pirrolopirrolona como inhibidores de elastasa neutrofilica, uso de dichos compuestos, metodos de tratamiento, procesos depreparacion e intermediarios utiles para su produccion | |
| AR037459A1 (es) | Antagonistas vi del receptor ccr-3 | |
| AR015521A1 (es) | Ftalimido arilpiperazinas, y composiciones farmacéuicas que las contienen. | |
| WO2006092507A8 (fr) | Derives de 1 ,2,4-triazines, leur preparation et leur application en therapeutique humaine | |
| RS50905B (sr) | Derivati benzopirana supstituisani sa sekundarnim aminima uključujući tetrazol, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže | |
| AR019438A1 (es) | Compuesto derivado de piperazina, usos del mismo y metodos para su fabricacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |