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AR013370A1 - Derivados de 1,2,3,4-tetrahidronaftaleno sustituidos, formulacion farmaceutica que los comprende, su uso en la manufactura de un medicamento,proceso para su preparacion y compuestos intermediarios - Google Patents

Derivados de 1,2,3,4-tetrahidronaftaleno sustituidos, formulacion farmaceutica que los comprende, su uso en la manufactura de un medicamento,proceso para su preparacion y compuestos intermediarios

Info

Publication number
AR013370A1
AR013370A1 ARP980103667A ARP980103667A AR013370A1 AR 013370 A1 AR013370 A1 AR 013370A1 AR P980103667 A ARP980103667 A AR P980103667A AR P980103667 A ARP980103667 A AR P980103667A AR 013370 A1 AR013370 A1 AR 013370A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
6alkyl
phenyl
substituted
Prior art date
Application number
ARP980103667A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR013370A1 publication Critical patent/AR013370A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivados de 1,2,3,4-tetrahidronaftaleno piperidil o piperazinilo -5- sustituidos que tienen la formula (I), en la cual: X es N o CH; Y es NR2CH2,CH2-NR2, NR2-CO, CO-NR2, o NR2SO2, en la cual R2 es H o C1-6 alquilo; R1 es H, C1-6alqu ilo o C3-6 cicloalquilo; R3 es C1-6 alquilo, C3-6cicloalquilo o (CH2)n-arilo; en lo cual arilo es fenilo o un anillo hetero- aromático que contiene uno o dos heteroátomos seleccionados entre N, O y S, yque puede estar mono- o di-sustituidopor R4 y/o R5; en lo cual R4 es H, C1-6 alquilo, C3-6 cicloalquilo, halogeno, CN, CF3, OH, C1-6 alcoxi, NR6R7, OCF3,SO2CH3, SO3CF3, SO2NR6R7, fenilo C1-6 alquilo, fenoxi, C1-6 alquil fenilo, un anillo heterocíclico opcionalmente sustituido quecontiene uno o másheteroátomos seleccionados entre N, O, S, SO y SO2 en lo cual el (los) sustituyente (s) es (son) seleccionados entre C1-6 alquilo, C3-6 cicloalquilo yfenil C1-6 alquilo, un anillo heteroaromático opcionalmente sustituidoque c ontiene dos o más heteroátomos seleccionados entre N, O y S, en lo cual el(los) sustituyente(s) es (son) seleccionados entre C1-6 alquilo, C3-6 cicloalquilo y fenil C1-6 alquilo, o COR8; en lo cual R6 es H, C1-6 alquilo oC3-6alquilo o C3-6 cicloalquilo; R7 es C1-6 alquilo o C3-6 cicloalquilo; y R8 es C1-6 alquilo, C3-6 cicloalquilo, CF3, NR6R7, fenilo, un anilloheteroaromático que contiene uno o más heteroátomos seleccionados entre N, O y S o un anilloheterocíclico que contiene uno o dos heteroátomos seleccionadosentre N, O, S, SO y SO2; en lo cual R5 es H, OH, CF3, OCF3, halogeno, C1-6 alquilo o C1-6 alcoxi; n vale de 0 a 4; R9 es C1-6 alquilo, C3-6 cicloalquilo,OCF3, OCHF2, OCH2F,halogeno, CN, CF3, OH, C1-6 alcoxi, C1-6 alcoxi C1-6 alquilo, NR6R7, SO3CF3, SO2NR6R7, un anillo heterocíclico o heteroátomos no
ARP980103667A 1997-07-25 1998-07-24 Derivados de 1,2,3,4-tetrahidronaftaleno sustituidos, formulacion farmaceutica que los comprende, su uso en la manufactura de un medicamento,proceso para su preparacion y compuestos intermediarios AR013370A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702799A SE9702799D0 (sv) 1997-07-25 1997-07-25 New compounds

Publications (1)

Publication Number Publication Date
AR013370A1 true AR013370A1 (es) 2000-12-27

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ID=20407828

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP980103667A AR013370A1 (es) 1997-07-25 1998-07-24 Derivados de 1,2,3,4-tetrahidronaftaleno sustituidos, formulacion farmaceutica que los comprende, su uso en la manufactura de un medicamento,proceso para su preparacion y compuestos intermediarios
ARP040103875A AR046193A2 (es) 1997-07-25 2004-10-25 Derivados de piperidil o piperazinil 1,2,3,4-tetrahidronaftaleno sustituido, formulacion farmaceutica, usos en la manufactura de medicamentos, y proceso para su preparacion

Family Applications After (1)

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ARP040103875A AR046193A2 (es) 1997-07-25 2004-10-25 Derivados de piperidil o piperazinil 1,2,3,4-tetrahidronaftaleno sustituido, formulacion farmaceutica, usos en la manufactura de medicamentos, y proceso para su preparacion

Country Status (36)

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US (3) US6313118B1 (es)
EP (1) EP1000048B1 (es)
JP (1) JP3895923B2 (es)
KR (1) KR20010022171A (es)
CN (1) CN1270585A (es)
AR (2) AR013370A1 (es)
AT (1) ATE228510T1 (es)
AU (1) AU739569B2 (es)
BR (1) BR9811042A (es)
CA (1) CA2296518A1 (es)
DE (1) DE69809755T2 (es)
DK (1) DK1000048T3 (es)
DZ (1) DZ2569A1 (es)
EE (1) EE04238B1 (es)
ES (1) ES2187983T3 (es)
HR (1) HRP980404B1 (es)
HU (1) HUP0004334A3 (es)
ID (1) ID24583A (es)
IL (1) IL134108A0 (es)
IS (1) IS5358A (es)
MA (1) MA26521A1 (es)
NO (1) NO315609B1 (es)
NZ (1) NZ502384A (es)
PL (1) PL338563A1 (es)
PT (1) PT1000048E (es)
RU (1) RU2194696C2 (es)
SE (1) SE9702799D0 (es)
SI (1) SI1000048T1 (es)
SK (1) SK283918B6 (es)
TN (1) TNSN98141A1 (es)
TR (1) TR200000229T2 (es)
TW (1) TW438781B (es)
UA (1) UA69389C2 (es)
WO (1) WO1999005134A1 (es)
YU (1) YU2300A (es)
ZA (1) ZA986588B (es)

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JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
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GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
GB201318222D0 (en) 2013-10-15 2013-11-27 Takeda Pharmaceutical Novel compounds
GB201320905D0 (en) 2013-11-27 2014-01-08 Takeda Pharmaceutical Therapeutic compounds
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
GB201616839D0 (en) 2016-10-04 2016-11-16 Takeda Pharmaceutical Company Limited Therapeutic compounds
GB201619514D0 (en) 2016-11-18 2017-01-04 Takeda Pharmaceuticals Co Novel compounds
JP2021138648A (ja) 2020-03-04 2021-09-16 武田薬品工業株式会社 経口固形製剤

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Also Published As

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AR046193A2 (es) 2005-11-30
DK1000048T3 (da) 2003-03-03
CN1270585A (zh) 2000-10-18
SK188399A3 (en) 2000-07-11
EE04238B1 (et) 2004-02-16
NO315609B1 (no) 2003-09-29
ES2187983T3 (es) 2003-06-16
HK1025963A1 (en) 2000-12-01
TW438781B (en) 2001-06-07
TR200000229T2 (tr) 2000-06-21
US20010051623A1 (en) 2001-12-13
ATE228510T1 (de) 2002-12-15
AU739569B2 (en) 2001-10-18
DE69809755D1 (de) 2003-01-09
SI1000048T1 (en) 2003-04-30
CA2296518A1 (en) 1999-02-04
SK283918B6 (sk) 2004-05-04
US6313118B1 (en) 2001-11-06
NO20000356L (no) 2000-03-27
EE200000041A (et) 2000-10-16
AU8370398A (en) 1999-02-16
NZ502384A (en) 2001-05-25
BR9811042A (pt) 2000-08-15
DE69809755T2 (de) 2003-07-17
KR20010022171A (ko) 2001-03-15
NO20000356D0 (no) 2000-01-24
UA69389C2 (uk) 2004-09-15
ID24583A (id) 2000-07-27
RU2194696C2 (ru) 2002-12-20
US6534652B2 (en) 2003-03-18
IS5358A (is) 2000-01-24
IL134108A0 (en) 2001-04-30
ZA986588B (en) 1999-01-25
HRP980404B1 (en) 2002-10-31
PT1000048E (pt) 2003-03-31
HUP0004334A3 (en) 2002-10-28
SE9702799D0 (sv) 1997-07-25
US20010051626A1 (en) 2001-12-13
JP3895923B2 (ja) 2007-03-22
EP1000048A1 (en) 2000-05-17
HRP980404A2 (en) 1999-04-30
US6410532B2 (en) 2002-06-25
MA26521A1 (fr) 2004-12-20
JP2001510837A (ja) 2001-08-07
YU2300A (sh) 2002-10-18
EP1000048B1 (en) 2002-11-27
PL338563A1 (en) 2000-11-06
TNSN98141A1 (fr) 2005-03-15
DZ2569A1 (fr) 2003-02-15
HUP0004334A2 (en) 2001-03-28
WO1999005134A1 (en) 1999-02-04

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