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AR009127A1 - Procedimiento de preparacion de nanoparticulas de metilideno malona, particulas que contienen eventualmente una o mas moleculas biologicamente activas y composiciones farmaceuticas que las contienen - Google Patents

Procedimiento de preparacion de nanoparticulas de metilideno malona, particulas que contienen eventualmente una o mas moleculas biologicamente activas y composiciones farmaceuticas que las contienen

Info

Publication number
AR009127A1
AR009127A1 ARP970104915A ARP970104915A AR009127A1 AR 009127 A1 AR009127 A1 AR 009127A1 AR P970104915 A ARP970104915 A AR P970104915A AR P970104915 A ARP970104915 A AR P970104915A AR 009127 A1 AR009127 A1 AR 009127A1
Authority
AR
Argentina
Prior art keywords
nanoparticles
pharmaceutical compositions
biologically active
active molecules
malona
Prior art date
Application number
ARP970104915A
Other languages
English (en)
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of AR009127A1 publication Critical patent/AR009127A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/12—Esters of phenols or saturated alcohols
    • C08F22/14—Esters having no free carboxylic acid groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Se refiere a un procedimiento de preparacion de nanopartículas formadas por un polímero estadístico de por lo menos un compuesto de formula (I) en lacual -A es un grupo (formula 2) o, * un grupo (formula 3) R1 y R2, idénticos o diferentes,rep resenta un grupo C1-C6 alquilo lineal o ramificado; n = 1, 2,3, 4 o 5, donde el monomero es previamente solubilizado en un solvente orgánico aprotico miscible con el agua, formando con el medio de polimerizacionuna mezcla no solventedel pol ímero formado. Se refiere también a dichas nanopartículas, conteniendo eventualmente una o varias moléculasbiologicamente activas y las composiciones farmacéuticas que las contienen.
ARP970104915A 1996-10-25 1997-10-24 Procedimiento de preparacion de nanoparticulas de metilideno malona, particulas que contienen eventualmente una o mas moleculas biologicamente activas y composiciones farmaceuticas que las contienen AR009127A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613039A FR2755136B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR009127A1 true AR009127A1 (es) 2000-03-08

Family

ID=9497032

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104915A AR009127A1 (es) 1996-10-25 1997-10-24 Procedimiento de preparacion de nanoparticulas de metilideno malona, particulas que contienen eventualmente una o mas moleculas biologicamente activas y composiciones farmaceuticas que las contienen

Country Status (23)

Country Link
US (2) US6211273B1 (es)
EP (1) EP0934059B1 (es)
JP (1) JP2001504530A (es)
KR (1) KR20000052813A (es)
CN (1) CN1237903A (es)
AR (1) AR009127A1 (es)
AT (1) ATE245171T1 (es)
AU (1) AU736097B2 (es)
BR (1) BR9712372A (es)
CA (1) CA2269783C (es)
CZ (1) CZ144099A3 (es)
DE (1) DE69723571T2 (es)
FR (1) FR2755136B1 (es)
HU (1) HUP9904359A3 (es)
IL (1) IL129355A0 (es)
NO (1) NO991942L (es)
NZ (1) NZ335094A (es)
PL (1) PL332957A1 (es)
RU (1) RU2214421C2 (es)
SK (1) SK55599A3 (es)
TW (1) TW503109B (es)
WO (1) WO1998018455A1 (es)
ZA (1) ZA979550B (es)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
FR2774096B1 (fr) * 1998-01-29 2000-04-07 Virsol Nouveaux copolymeres tensioactifs a base de methylidene malonate
FR2778100B1 (fr) * 1998-04-29 2001-05-04 Virsol Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
FR2789314B1 (fr) * 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
US6958366B2 (en) * 2000-04-12 2005-10-25 Dainippon Ink And Chemicals, Inc. Antifouling coating composition and novel resin
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
AU2002211602A1 (en) * 2000-10-11 2002-04-22 Johns Hopkins University Polymer controlled delivery of a therapeutic agent
KR100457824B1 (ko) * 2001-08-10 2004-11-18 한국화학연구원 용액 열분해법에 의한 나노 크기 2가 금속 산화물 분말의제조
JP3961312B2 (ja) 2002-02-26 2007-08-22 株式会社デンソー 内燃機関の制御装置
WO2008018932A2 (en) * 2006-05-01 2008-02-14 The Board Of Trustees Of The Leland Stanford Junior University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2123262A1 (en) 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
US8993795B2 (en) 2009-05-07 2015-03-31 Optmed Inc Methylidene malonate process
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
KR20140020236A (ko) 2010-10-20 2014-02-18 바이오포믹스, 인크. 열 전달제 존재하에서의 빠른 회수를 사용하는 메틸렌 말로네이트의 합성
US9279022B1 (en) * 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9249265B1 (en) * 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
WO2013059473A2 (en) 2011-10-19 2013-04-25 Bioformix Inc. Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed therefrom
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
US9234107B2 (en) 2012-03-30 2016-01-12 Sirrus, Inc. Ink coating formulations and polymerizable systems for producing the same
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
EP2920231B1 (en) 2012-11-16 2020-05-06 Sirrus, Inc. Plastics bonding systems and methods
WO2014085570A1 (en) 2012-11-30 2014-06-05 Bioformix, Inc. Composite compositions for electronics applications
CN105008321A (zh) 2013-01-11 2015-10-28 瑟拉斯公司 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) * 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
EP3310821B1 (en) * 2015-06-19 2021-02-17 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
CA3064314A1 (en) 2017-06-02 2018-12-06 Arkema France Curable compositions and uses thereof
WO2020123579A1 (en) * 2018-12-11 2020-06-18 Sirrus, Inc. Polymerization of 1,1-dicarbonyl 1-alkenes
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US4329332A (en) * 1978-07-19 1982-05-11 Patrick Couvreur Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them
FR2611705B1 (fr) * 1987-03-05 1989-07-13 Union Pharma Scient Appl Procede de preparation de monesters ou diesters de l'acide endoethano-9, 10 dihydro-9, 10 anthracene bicarboxylique-11, 11, nouveaux monesters ou diesters ainsi prepares et utilisation de ceux-ci pour la preparation de methylenemalonates symetriques ou asymetriques
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Also Published As

Publication number Publication date
CZ144099A3 (cs) 1999-09-15
FR2755136A1 (fr) 1998-04-30
NO991942L (no) 1999-06-23
PL332957A1 (en) 1999-10-25
HUP9904359A2 (hu) 2000-05-28
WO1998018455A1 (fr) 1998-05-07
ATE245171T1 (de) 2003-08-15
RU2214421C2 (ru) 2003-10-20
DE69723571D1 (de) 2003-08-21
US20010006989A1 (en) 2001-07-05
DE69723571T2 (de) 2004-06-03
US6211273B1 (en) 2001-04-03
BR9712372A (pt) 2000-01-25
TW503109B (en) 2002-09-21
HUP9904359A3 (en) 2000-11-28
SK55599A3 (en) 2000-03-13
AU736097B2 (en) 2001-07-26
JP2001504530A (ja) 2001-04-03
US6420468B2 (en) 2002-07-16
EP0934059B1 (fr) 2003-07-16
AU4950997A (en) 1998-05-22
NZ335094A (en) 2001-05-25
CA2269783A1 (en) 1998-05-07
NO991942D0 (no) 1999-04-23
CA2269783C (en) 2005-01-11
KR20000052813A (ko) 2000-08-25
FR2755136B1 (fr) 1999-01-22
EP0934059A1 (fr) 1999-08-11
ZA979550B (en) 1998-05-12
IL129355A0 (en) 2000-02-17
CN1237903A (zh) 1999-12-08

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