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ES2176189T3 - Mezlas de polimeros biodegradables para uso medicamentosos. - Google Patents

Mezlas de polimeros biodegradables para uso medicamentosos.

Info

Publication number
ES2176189T3
ES2176189T3 ES92908387T ES92908387T ES2176189T3 ES 2176189 T3 ES2176189 T3 ES 2176189T3 ES 92908387 T ES92908387 T ES 92908387T ES 92908387 T ES92908387 T ES 92908387T ES 2176189 T3 ES2176189 T3 ES 2176189T3
Authority
ES
Spain
Prior art keywords
mixtures
polyesters
polymers
prepared
active agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92908387T
Other languages
English (en)
Inventor
Abraham J Domb
Manoj Maniar
Andrew T S Haffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2176189T3 publication Critical patent/ES2176189T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN MEZCLAS DE POLIMEROS QUE TIENEN PROPIEDADES DISTINTAS DE LOS COMPONENTES POLIMEROS INDIVIDUALES, Y QUE SON ADECUADAS PARA SU USO COMO PORTADORES DE AGENTES FARMACOLOGICAMENTE ACTIVOS, LAS MEZCLAS SE PREPARAN A PARTIR DE DOS O MAS POLIANHIDRIDOS, POLIESTERES O MEZCLAS DE POLIANHIDRIDOS Y POLIESTERES. LAS MEZCLAS TIENEN PROPIEDADES DIFERENTES A LAS DE LOS POLIMEROS USADOS PARA PREPARAR LAS MEZCLAS, SUMINISTRANDO UN MEDIO PARA LA ALTERACION DE LAS CARACTERISTICAS DE UNA MATRIZ POLIMERICA SIN ALTERAR LA ESTRUCTURA QUIMICA DE LOS POLIMEROS COMPONENTES. LAS MEZCLAS DE VARIOS POLIANHIDRIDOS, POLIESTERES, Y POLIANHIDRIDOS Y POLIESTERES, QUE CONTIENEN AGENTES FARMACOLOGICAMENTE ACTIVOS, SE PREPARAN USANDO MEZCLAS DE SOLVENTES O PROCEDIMIENTOS DE MEZCLAS DE SOLVENTES. SE HA DESCUBIERTO QUE LA VELOCIDAD DE LIBERACION DEL AGENTE DE LAS MEZCLAS ES DIFERENTE QUE LA VELOCIDAD DE LIBERACION DE LOS COMPONENTES POLIANHIDRIDOS Y POLIESTERES INDIVIDUALES, SIENDO UNA FUNCION DE LA MEZCLA DE LA COMPOSICION.
ES92908387T 1991-02-01 1992-01-31 Mezlas de polimeros biodegradables para uso medicamentosos. Expired - Lifetime ES2176189T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64892791A 1991-02-01 1991-02-01

Publications (1)

Publication Number Publication Date
ES2176189T3 true ES2176189T3 (es) 2002-12-01

Family

ID=24602790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92908387T Expired - Lifetime ES2176189T3 (es) 1991-02-01 1992-01-31 Mezlas de polimeros biodegradables para uso medicamentosos.

Country Status (10)

Country Link
US (1) US5919835A (es)
EP (1) EP0568651B1 (es)
JP (1) JP3137337B2 (es)
AT (1) ATE216262T1 (es)
AU (1) AU669479B2 (es)
CA (1) CA2101742C (es)
DE (1) DE69232555T2 (es)
DK (1) DK0568651T3 (es)
ES (1) ES2176189T3 (es)
WO (1) WO1992013567A1 (es)

Families Citing this family (36)

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WO1993020134A1 (en) * 1992-03-30 1993-10-14 Alza Corporation Additives for bioerodible polymers to regulate degradation
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
ATE183092T1 (de) 1995-10-28 1999-08-15 Braun Melsungen Ag Lokalanästhetika und/oder zentralanalgetika enthaltende pharmazeutische zusammensetzungen
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
JP4644374B2 (ja) * 1999-04-16 2011-03-02 ウィリアム・マーシュ・ライス・ユニバーシティ ポリ（エチレングリコール）と架橋したポリ（プロピレンフマラート）
US6113678A (en) * 1999-09-23 2000-09-05 Xerox Corporation Hot melt inks containing polyanhydrides
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US20030170289A1 (en) * 2001-11-14 2003-09-11 Guohua Chen Injectable depot compositions and uses thereof
IL162001A0 (en) * 2001-11-14 2005-11-20 Alza Corp Catheter injectable depot compositions and uses thereof
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
DE60226282T2 (de) * 2002-07-31 2009-09-17 Alza Corp., Mountain View Injizierbare depotzusammensetzungen und deren verwendung
BR0313539A (pt) * 2002-07-31 2005-06-21 Alza Corp Composições depósito de polìmero multimodais injetáveis e seus usos
AU2003258209A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
US20040127978A1 (en) * 2002-08-13 2004-07-01 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
WO2004014453A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc Medical device exhibiting improved adhesion between polymeric coating and substrate
EP1539265B1 (en) * 2002-08-13 2007-09-26 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivate
US20040047911A1 (en) * 2002-08-13 2004-03-11 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method
US6911400B2 (en) * 2002-11-05 2005-06-28 International Business Machines Corporation Nonlithographic method to produce self-aligned mask, articles produced by same and compositions for same
US20050064005A1 (en) * 2003-08-13 2005-03-24 Dinh Thomas Q. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
EP1660145A2 (en) * 2003-08-13 2006-05-31 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices and methods
FR2859909B1 (fr) 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US20070200268A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from solution processing
US20070200271A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from melt processing
KR101433550B1 (ko) 2007-03-07 2014-08-27 에코 테라퓨틱스, 인크. 경피 피분석물 모니터링 시스템 및 피분석물 검출 방법
NZ580997A (en) 2007-04-27 2011-08-26 Echo Therapeutics Inc Dermal abrasion device with feedback electrode to deliver data on skin thickness and removable abrasion heads
JP5139003B2 (ja) * 2007-08-17 2013-02-06 国立大学法人京都工芸繊維大学 組成物およびフィルム
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN109021215B (zh) * 2018-07-11 2021-03-02 中山大学 一种pH敏感型聚扁桃酸纳米药物载体及其制备方法和应用
AU2019320082B2 (en) * 2018-08-10 2025-02-06 Ephemeral Solutions, Inc. Particles containing coloring agents and methods of using the same
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522804A (en) * 1983-01-03 1985-06-11 Verex Laboratories, Inc. Constant release rate solid oral dosage formulations of propranolol
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4891225A (en) * 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
FR2612198A1 (fr) * 1987-03-27 1988-09-16 Tyndale Plains Hunter Ltd Composition de polyurethane hydrophile et article qui en est produit
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
CA2056384C (en) * 1989-06-05 1998-06-23 Tobin N. Gerhart Bioerodible polymers for drug delivery in bone
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
EP0423484B1 (de) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Pressling mit retardierter Wirkstofffreisetzung

Also Published As

Publication number Publication date
EP0568651A1 (en) 1993-11-10
DE69232555T2 (de) 2002-10-31
DK0568651T3 (da) 2002-08-05
JPH06508863A (ja) 1994-10-06
WO1992013567A1 (en) 1992-08-20
AU669479B2 (en) 1996-06-13
EP0568651B1 (en) 2002-04-17
US5919835A (en) 1999-07-06
AU1643292A (en) 1992-09-07
CA2101742A1 (en) 1992-08-02
JP3137337B2 (ja) 2001-02-19
ATE216262T1 (de) 2002-05-15
EP0568651A4 (en) 1996-11-27
CA2101742C (en) 2005-04-12
DE69232555D1 (de) 2002-05-23

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