AR005841A1 - Compuestos 1,4-dihidropiridina, su uso para preparar un medicamento util para tratar trastornos provocados por la bradiquinina y una composicionfarmaceutica que los contiene - Google Patents
Compuestos 1,4-dihidropiridina, su uso para preparar un medicamento util para tratar trastornos provocados por la bradiquinina y una composicionfarmaceutica que los contieneInfo
- Publication number
- AR005841A1 AR005841A1 ARP970100614A ARP970100614A AR005841A1 AR 005841 A1 AR005841 A1 AR 005841A1 AR P970100614 A ARP970100614 A AR P970100614A AR P970100614 A ARP970100614 A AR P970100614A AR 005841 A1 AR005841 A1 AR 005841A1
- Authority
- AR
- Argentina
- Prior art keywords
- prepare
- pharmaceutical composition
- composition containing
- useful
- bradiquinine
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- -1 1,4-dihydropyridine compound Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000004221 Multiple Trauma Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical compound C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 abstract 1
- 239000003152 bradykinin antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuesto 1,4-dihidropiridina de fórmula y sus sales farmacéuticamente aceptables, en la que A1 y A2 son cada uno halógeno; X es CO, S(O)2 o S(O)-(CH2)n donde el átomo de S está unido directamente al fenilo y n es 0, 1 o 2; y R1 es 8-azabiciclo[3.2.1]octilo, quinuclidinilo, biciclo[3.3.0]octilo,cicloalquilo C3-10, 2,3,5,6-tetrahidro-4H-tiopiranilo cicloalquilo C3-6 alquilo C1-4, opcionalmente sustituido con alquilo C1-14, hidroxi, dioxaranilo u oxo.Los compuestos nuevos dihidropiridina tienen una excelente actividad antagonista de la bradiquinina y, por ello, son útiles para el tratamiento detrastornos médicos provocados por la bradiquinina, tales como la inflamación, enfermedad cardiovacular, dolor, catarro común, alergias, asma, pancreatitis,quemaduras, infección viral, herida en la cabeza, trauma múltiple o similares en mamíferos, especialmente en humanos. Se describe además una composiciónfarmacéutica que los contiene, y el uso del compuesto activo para preparar un medicamento útil para el tratamiento de transtornos provocados por labradiquinina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB9600132 | 1996-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005841A1 true AR005841A1 (es) | 1999-07-14 |
Family
ID=11004406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100614A AR005841A1 (es) | 1996-02-19 | 1997-02-17 | Compuestos 1,4-dihidropiridina, su uso para preparar un medicamento util para tratar trastornos provocados por la bradiquinina y una composicionfarmaceutica que los contiene |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6131226A (es) |
| EP (1) | EP0882044B1 (es) |
| JP (1) | JP3167335B2 (es) |
| KR (1) | KR19990082678A (es) |
| CN (1) | CN1211251A (es) |
| AR (1) | AR005841A1 (es) |
| AT (1) | ATE220676T1 (es) |
| AU (1) | AU1396497A (es) |
| BG (1) | BG102678A (es) |
| BR (1) | BR9707568A (es) |
| CA (1) | CA2245857C (es) |
| CO (1) | CO4650041A1 (es) |
| CZ (1) | CZ258698A3 (es) |
| DE (1) | DE69714019T2 (es) |
| DK (1) | DK0882044T3 (es) |
| ES (1) | ES2177921T3 (es) |
| HN (1) | HN1997000013A (es) |
| HR (1) | HRP970094A2 (es) |
| HU (1) | HUP9902810A3 (es) |
| ID (1) | ID16434A (es) |
| IL (1) | IL124867A0 (es) |
| IS (1) | IS4783A (es) |
| MA (1) | MA26419A1 (es) |
| NO (1) | NO983776L (es) |
| NZ (1) | NZ325455A (es) |
| OA (1) | OA10712A (es) |
| PE (1) | PE36298A1 (es) |
| PL (1) | PL328514A1 (es) |
| PT (1) | PT882044E (es) |
| SI (1) | SI0882044T1 (es) |
| TN (1) | TNSN97037A1 (es) |
| TR (1) | TR199801593T2 (es) |
| WO (1) | WO1997030048A1 (es) |
| ZA (1) | ZA971357B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物 |
| US6653313B2 (en) * | 2000-08-10 | 2003-11-25 | Warner-Lambert Company Llc | 1,4-dihydropyridine compounds as bradykinin antagonists |
| GB0427281D0 (en) * | 2004-12-14 | 2005-01-12 | 3M Innovative Properties Co | Methods of providing medicinal metal components having through holes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120750A (en) * | 1989-01-17 | 1992-06-09 | Synphar Laboratories, Inc. | Generation of 1,4-dihydropyridine derivatives |
| WO1996006083A1 (en) * | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists |
| MX9701245A (es) * | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
-
1996
- 1996-02-18 TN TNTNSN97037A patent/TNSN97037A1/fr unknown
-
1997
- 1997-01-27 BR BR9707568A patent/BR9707568A/pt active Search and Examination
- 1997-01-27 AT AT97900401T patent/ATE220676T1/de not_active IP Right Cessation
- 1997-01-27 KR KR1019980706424A patent/KR19990082678A/ko not_active Application Discontinuation
- 1997-01-27 TR TR1998/01593T patent/TR199801593T2/xx unknown
- 1997-01-27 HU HU9902810A patent/HUP9902810A3/hu unknown
- 1997-01-27 IL IL12486797A patent/IL124867A0/xx unknown
- 1997-01-27 PT PT97900401T patent/PT882044E/pt unknown
- 1997-01-27 AU AU13964/97A patent/AU1396497A/en not_active Abandoned
- 1997-01-27 NZ NZ325455A patent/NZ325455A/xx unknown
- 1997-01-27 DE DE69714019T patent/DE69714019T2/de not_active Expired - Fee Related
- 1997-01-27 CZ CZ982586A patent/CZ258698A3/cs unknown
- 1997-01-27 DK DK97900401T patent/DK0882044T3/da active
- 1997-01-27 HN HN1997000013A patent/HN1997000013A/es unknown
- 1997-01-27 SI SI9730361T patent/SI0882044T1/xx unknown
- 1997-01-27 EP EP97900401A patent/EP0882044B1/en not_active Expired - Lifetime
- 1997-01-27 CN CN97192240A patent/CN1211251A/zh active Pending
- 1997-01-27 JP JP52913897A patent/JP3167335B2/ja not_active Expired - Fee Related
- 1997-01-27 PL PL97328514A patent/PL328514A1/xx unknown
- 1997-01-27 WO PCT/IB1997/000058 patent/WO1997030048A1/en active IP Right Grant
- 1997-01-27 ES ES97900401T patent/ES2177921T3/es not_active Expired - Lifetime
- 1997-01-27 CA CA002245857A patent/CA2245857C/en not_active Expired - Fee Related
- 1997-01-27 US US09/125,137 patent/US6131226A/en not_active Expired - Fee Related
- 1997-02-10 PE PE1997000085A patent/PE36298A1/es not_active Application Discontinuation
- 1997-02-13 CO CO97007547A patent/CO4650041A1/es unknown
- 1997-02-17 AR ARP970100614A patent/AR005841A1/es unknown
- 1997-02-18 ID IDP970467A patent/ID16434A/id unknown
- 1997-02-18 HR HRPCT/IB96/00132A patent/HRP970094A2/xx not_active Application Discontinuation
- 1997-02-18 MA MA24498A patent/MA26419A1/fr unknown
- 1997-02-18 ZA ZA971357A patent/ZA971357B/xx unknown
-
1998
- 1998-06-25 IS IS4783A patent/IS4783A/is unknown
- 1998-07-10 OA OA9800111A patent/OA10712A/en unknown
- 1998-08-10 BG BG102678A patent/BG102678A/xx unknown
- 1998-08-18 NO NO983776A patent/NO983776L/no unknown
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