(Q21260429)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

0 references

1 reference

1 reference

Nils Cordes

Nils

Cordes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Claus Belka

Claus

Belka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Daniel Habermehl

Daniel

Habermehl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Bernd Kammerer

Bernd

Kammerer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

René Handrick

René

Handrick

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Therese Eldh

Therese

Eldh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Charlotte Gruber

Charlotte

Gruber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Peter T Daniel

Peter T

Daniel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Ludwig Plasswilm

Ludwig

Plasswilm

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Michael Bamberg

Michael

Bamberg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Verena Jendrossek

Verena

Jendrossek

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

English

0 references

publication date

17 January 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

15 January 2020

https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-6-14

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1186/1471-2407-6-14?email=unpaywall_01@example.com

published in

BMC Cancer

1 reference

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15 January 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1186/1471-2407-6-14?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

Ukrain - a new cancer cure? A systematic review of randomised clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis

19 March 2017

1 reference

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Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

New approaches and therapeutics targeting apoptosis in disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Type I and type II reactions in TRAIL-induced apoptosis -- results from dose-response studies.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Histone deacetylase inhibitors open new doors in cancer therapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Mitochondrial regulation of apoptotic cell death

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Apoptosis-modulating agents in combination with radiotherapy-current status and outlook

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Death receptor-induced cell killing

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Guardians of cell death: the Bcl-2 family proteins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Many cuts to ruin: a comprehensive update of caspase substrates

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Induction of apoptosis in cultured Chinese hamster ovary cells by Ukrain and its synergistic action with etoposide.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Radiation sensitivity and apoptosis in human lymphoma cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Ukrain(TM), a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerization in normal and malignant cell lines.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Acute hepatitis induced by greater celandine (Chelidonium majus).

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Anti-thrombotic and anti-inflammatory activities of protopine.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma(3SBH5) cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Bcl-2 overexpression protects human keratinocyte cells from Ukrain-induced apoptosis but not from G2/M arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Benzophenanthridine alkaloids of Chelidonium majus; II. Potent inhibitory action against the growth of human keratinocytes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Intracellular mediators of erucylphosphocholine-induced apoptosis

30 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

Water extract isolated from Chelidonium majus enhances nitric oxide and tumour necrosis factor-alpha production via nuclear factor-kappaB activation in mouse peritoneal macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

Identification of chelerythrine as an inhibitor of BclXL function

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-14

Effect of Ukrain on the growth and metastasizing of Lewis carcinoma in C57BL/6 mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Celecoxib activates a novel mitochondrial apoptosis signaling pathway

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1379651

Acute hepatitis induced by Greater Celandine (Chelidonium majus)

29 November 2018

1 reference

12 December 2020

Enhancement of macrophage tumouricidal activity by the alkaloid derivative Ukrain. In vitro and in vivo studies

1 reference

12 December 2020

Preliminary studies on the effect of Ukrain (Tris(2-([5bS-(5ba,6b,12ba)]- 5b,6,7,12b,13,14-hexahydro-13-methyl[1,3] benzodioxolo[5,6-v]-1-3- dioxolo[4,5-i]phenanthridinium-6-ol]-Ethaneaminyl)Phosphinesulfide.6HCl ) on the immunological response in p

1 reference

12 December 2020

The effects of thiophosphoric acid (Ukrain) on cervical cancer, stage IB bulky

1 reference

12 December 2020

Antimicrotubule properties of benzophenanthridine alkaloids

1 reference

12 December 2020

Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570)

1 reference

12 December 2020

Influence of Ukrain on human xenografts in vitro

1 reference

12 December 2020

Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism

1 reference

12 December 2020

Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation

1 reference

12 December 2020

Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum

1 reference

12 December 2020

Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis

1 reference

12 December 2020

Induced G2/M arrest and apoptosis in human epidermoid carcinoma cell lines by semisynthetic drug Ukrain

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-6-14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

16417634

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417634%20AND%20SRC:MED&resulttype=core&format=json