DNA nanotechnology is useful in preparing nano- and meso-components, but transfer to macroscale arrangements is challenging. Here, the authors report an assembly approach combining DNA programmable assembly with process controlled by acoustic fields to prepare macroscale morphologies.

The authors present the generation of laser harmonics with tunable orbital angular momentum by directing a laser at shaped targets. The combined frequency and OAM spectrum can be controlled via the target shape and the pump laser topology.

The authors report a multimodal tactile sensor with perceptions of pressure, temperature, material thermal property, texture, slippage, and a robotic decision-making tactile-visual fusion architecture which allows robots for dexterous housekeeping.

Transporting charged particles in a guided manner, similar to how optical fibers carry light signals, has the potential to profoundly impact the scientific and technological landscape. Here, the authors propose a viable method to realize these waveguides by leveraging Lagrange points created by the electrostatic potential around a carefully designed twisted wire in a vacuum.

The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature of steric hindrance at ortho-aryl substituents. Herein, the authors report the synthesis of diverse atropisomeric arylpyrroles with 1,2-diaxes, and C–C and C–N axes via a remote stereocontrol strategy.

Major strike-slip faults that develop between strong and weaker regions are thought to focus along narrow shear zones at the rheological boundary. Here the authors present the InSAR-derived velocity field spanning almost the entire length of one such fault, the 1600 km-long Altyn Tagh Fault, and analyse the strain distribution.

This study analyzes a global dataset of soil metagenomes to explore environmental drivers of growth potential, a fundamental aspect of bacterial life history. The authors show that growth potential, estimated from codon usage statistics, was highest in forested biomes and lowest in arid latitudes, which indicates that bacterial productivity generally reflects ecosystem productivity globally.

The mantle’s oxygen fugacity has been constant since the Hadean, according to data from the ambient mantle and plume-derived melts. Mantle cooling reduced melting depth, which raised the fo₂ of mantle-derived melts and aided atmospheric oxygenation.

Trencher and colleagues investigate the twenty companies making the largest purchases of offsets from the voluntary carbon market from 2020 to 2023. They find that 87% of the purchased offsets carry a high risk of not providing real and additional emissions reductions. Further, most offsets do not meet industry standards regarding age and country of implementation. The findings reinforce concerns that the voluntary carbon market is failing to support effective climate mitigation.

Atmospheric oxygen levels tend to be stable under anoxic, low oxygen, and near-modern conditions, with two unstable states at around 10−5 and 10−1 present atmospheric level, according to the results from a stochastic analysis of oxygen mass balance.

Here Cao et al. provide a functional map of nucleic acid binding proteins that control germ cell proliferation and differentiation into gametes. This valuable resource provides a platform for dissecting gene networks that control animal fertility.

The molecular diversity and spatial organization of the mouse basolateral amygdala are unclear. Here, the authors classify 11 glutamatergic cell clusters and describe the roles of distinct neuron populations in different valence-specific behaviors.

The bactericidal activity of several antibiotics partially relies on production of reactive oxygen species (ROS), which requires the Fenton reaction. Here, the authors show that membrane depolarization also leads to ROS production, but this occurs via other mechanisms that do not require the Fenton reaction.

Mechanical stress during muscle contraction constantly threatens the proteome. Here, Kutzner et al. present the OptIMMuS model and identify the TRIM E3 ligase NHL-1 to regulate myosin levels and function upon mechanical stress.

With fMRI and computational models, Kupers et al. found that visually-driven neural computations in space and time, rather than limited neural sources, explain why brain responses are lower when we view multiple things at once vs one after the other.

It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. Here we show that people who have a poor diet, as indicated with a data-driven score, might be more susceptible to severe ALD due to alcohol consumption.

Lymphoplasmacytic lymphoma is a B-cell low-grade lymphoma with no approved standard therapy. Here the authors report a non-randomized phase 1 clinical trial performing early intervention with personalized neoantigen vaccines in asymptomatic patients and associating clinical efficacy with successful perturbation of the tumor immune microenvironment.

There is limited evidence of the prognostic significance of anticoagulant use in patients with ischemic left ventricular aneurysm (LVA) Here, the authors used a cohort database on ischemic LVA and found that anticoagulant therapy significantly reduces stroke risk without increasing major bleeding.

Despite new treatment options, prognosis for patients with glioblastoma (GBM) remains poor. Here the authors report the clinical course of patients with GBM treated with a personalized neoantigen-derived peptide vaccine treated within the scope of an individual healing attempt.

While AMPKα is known for its role in regulating GLUT4 trafficking and subsequent glucose uptake into cells, its upstream regulators are not well understood. The authors provide evidence that PAK4 acts as an inhibitory kinase for AMPKα, thus impairing glucose uptake in skeletal muscle.

Trencher and colleagues investigate the twenty companies making the largest purchases of offsets from the voluntary carbon market from 2020 to 2023. They find that 87% of the purchased offsets carry a high risk of not providing real and additional emissions reductions. Further, most offsets do not meet industry standards regarding age and country of implementation. The findings reinforce concerns that the voluntary carbon market is failing to support effective climate mitigation.

Offshore wind and wave energy may play a key role in the energy transition. Here, authors identify cost targets for these technologies to become cost effective and show how the grid’s installed capacity decreases, and generation and transmission change as offshore energy deployment increase.

Cyanobacteria have been the subject of intense basic research, but translation towards industrial applications remains limited. Here, Schmelling and Bross conduct a survey among researchers in the cyanobacterial community, as well as a literature analysis, to highlight potential strategies to enhance cyanobacterial research and accelerate the development of industrial applications.

The study investigates the potential of vertical bifacial photovoltaics (PV) adoption in the European electricity market. It shows that with up to 50% deployment, curtailment levels could be reduced, system costs lowered by around 3.8 billion Euros, and gas consumption decreased by nearly 12%.

Bridge fires cause significant disruptions and economic losses in modern society, yet fire hazards are still often ignored or oversimplified in bridge design. This Perspective emphasizes the need for more holistic and comprehensive fire-safety design when retrofitting or designing new bridges.