Ganoderma lucidum (Ling Zhi) is a basidiomycete white rot macrofungus which has been used extensively as "the mushroom of immortality" in China, Japan,... more
Ganoderma lucidum (Ling Zhi) is a basidiomycete white rot macrofungus which has been used extensively as "the mushroom of immortality" in China, Japan, Korea and other Asian countries for 2000 years. A great deal of work has been carried out on therapeutic potential of Ganoderma lucidum. The basidiocarp, mycelia and spores of Ganoderma lucidum contain approximately 400 different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements which has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemo-preventive, antitumor, chemo and radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-androgenic, anti-angiogenic, anti-herpetic, antioxidative and radical-scavenging, anti-aging, hypoglycemic, estrogenic activity and anti-ulcer properties. Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes. The macrofungus is very rare in nature rather not sufficient for commercial exploitation for vital therapeutic emergencies, therefore, the cultivation on solid substrates, stationary liquid medium or by submerged cultivation has become an essential aspect to meet the driving force towards the increasing demands in the international market. Present review focuses on the pharmacological aspects, cultivation methods and bioactive metabolites playing a significant role in various therapeutic applications.
Research Interests: Bioengineering, Pharmacology, Biochemistry, Bioinformatics, Microbiology, and 19 morePharmacy, Food Science, Immunology, Nutrition, Molecular Biology, Computational Biology, Toxicology, Biotechnology, Cancer, Food and Nutrition, Cancer Biology, Polysaccharides, Traditional Chinese Medicine, Humans, Medical Biotechnology, Animals, Ganoderma Lucidum, Current, and Reishi
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ABSTRACT The authors expressed a lot of enthusiasm towards the application of M. balsamina proteins for combating HIV/ AIDS but problems associated with toxicities and bioavailability of these proteins limit potential usefulness in such... more
ABSTRACT The authors expressed a lot of enthusiasm towards the application of M. balsamina proteins for combating HIV/ AIDS but problems associated with toxicities and bioavailability of these proteins limit potential usefulness in such therapies. A number of critical animal toxicological and human clinical studies should be carried out. Most of the studies that have been carried so far are inconclusive and requires further authentication before advocating this plant as a “hidden gift of nature”.
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The metabolic syndrome (Met S) is comprised of various medical conditions that confer increased risk of diabetes and cardiovascular disease. The pathophysiological components of MS include glucose abnormality, obesity or increased waist... more
The metabolic syndrome (Met S) is comprised of various medical conditions that confer increased risk of diabetes and cardiovascular disease. The pathophysiological components of MS include glucose abnormality, obesity or increased waist circumference, blood pressure, and hyperlipidemia. Methods: We studied the prevalence of the metabolic syndrome (MetS) in Gwalior- Chambal region of Central India, according to two definitions (NCEP- ATPIII and IDF); and we also examined these issues upon link between metabolic syndrome and diabetes. We conducted an examination survey on a sample representative of the general population aged 30-70 years, attended by 385 participants in which 275 males and 110 females. Conclusions: The prevalence of MetS increased markedly with age. According to the NCEP-ATPIII and IDF definitions, the prevalence of MetS was, 41.29% and 47.0% respectively. Approximately 65.15% of participants with diabetes also had MetS and the prevalence of MetS was approximately 7.7...
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Page 1. Letters in Drug Design & Discovery, 2004, 1, 314-328 314 1570-1808/04 $45.00+.00 © 2004 Bentham Science Publishers Ltd. Tuberculosis Therapeutics: Past Achievements, Present Road-Blocks and Future Perspectives... more
Page 1. Letters in Drug Design & Discovery, 2004, 1, 314-328 314 1570-1808/04 $45.00+.00 © 2004 Bentham Science Publishers Ltd. Tuberculosis Therapeutics: Past Achievements, Present Road-Blocks and Future Perspectives ...
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Iron mediated regulation of growth and siderophore production has been studied in a diazotrophic cyanobacterium Anabaena cylindrica. Iron-starved cells of A. cylindrica exhibited reduced growth (30%) when the cells were growing under... more
Iron mediated regulation of growth and siderophore production has been studied in a diazotrophic cyanobacterium Anabaena cylindrica. Iron-starved cells of A. cylindrica exhibited reduced growth (30%) when the cells were growing under N2-fixing conditions. In contrast, N03-, NO2-, NH4' and urea grown cells exhibited almost 50% reduction in their growth in the absence of iron as compared to their respective counterparts cultured in the presence of iron. However, at 60 microM of iron, A. cylindrica cells exhibited almost equal growth regardless of the nitrogen source available. Siderophore production in A. cylindrica was started after day 2nd of the cell growth and attained its optimal level on day 5th when the cells were at their mid-log phase. No siderophore production was, however, recorded on day 2nd at all the concentrations of iron tested. The production of siderophore in A. cylindrica further increased with increase in iron concentration and attained its optimum level on day...
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The aim of study was to determine the prevalence of metabolic syndrome (MetS) in people with type 2 diabetes mellitus (T2DM). National Cholesterol Education Program (NCEP) ATPIII Criteria, International Diabetes Federation and the World... more
The aim of study was to determine the prevalence of metabolic syndrome (MetS) in people with type 2 diabetes mellitus (T2DM). National Cholesterol Education Program (NCEP) ATPIII Criteria, International Diabetes Federation and the World Health Organization (WHO) definitions were used in quantifying the metabolic syndrome and also the concordance between these three criteria's used for identifying metabolic syndrome. This cross-sectional study involved 700 type 2 diabetic subjects from the urban areas of Gwalior Chambal region (Central India). Subjects in the age group of 28- 87 yrs were included in the study. Type I diabetics, pregnant ladies and those with chronic viral and bacterial infections and serious metabolic disorders were excluded from the study. Fasting blood glucose, Blood lipids (T-cholesterol, triglyceride, HDL-cholesterol) were assessed and anthropometry blood pressure were measured from all the subjects. The Prevalence of metabolic syndrome was found to be 45.8%,...