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The extraction and preliminary characterization of the present secondary metabolic in crust Grapefruit (Citrus Maxima) and the determination of its biological activity forehead to the Penicillum fungi ssp, Rhizopus ssp and cinerea... more
The extraction and preliminary characterization of the present secondary metabolic in crust Grapefruit (Citrus Maxima) and the determination of its biological activity forehead to the Penicillum fungi ssp, Rhizopus ssp and cinerea Botrytis, in conditions of Laboratory like possible conservant activity. Also an nourishing natural colorant from the metanolic extraction of present antocianinas in the was obtained mora de castilla (Rubus glaucus benth); and the characterization of the extract by CCD, along with an analysis of stability as opposed to different environmental conditions and tests of toxicity (saline Artemia)
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Asymptotic Behavior of Electromagnetic Form Factors. Patrick J. O'Donovan The Enrico Fermi Institute for Nuclear Studies, The University of Chicago, Chicago, Illinois. Received 31 August 1967 The asymptotic behavior of the ...
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Background: AA is the prodrug of abiraterone (A), an androgen biosynthesis inhibitor that selectively inhibits CYP17, thereby blocking testicular, adrenal, and prostatic intratumoral androgen biosynthesis. In a phase 3 study, AA+P... more
Background: AA is the prodrug of abiraterone (A), an androgen biosynthesis inhibitor that selectively inhibits CYP17, thereby blocking testicular, adrenal, and prostatic intratumoral androgen biosynthesis. In a phase 3 study, AA+P demonstrated survival improvements in post-docetaxel mCRPC pts (De Bono ESMO 2010). ADT with an LHRH analog (LHRHa) has been associated with median QTc interval prolongation of 9–21 msec (Garnick ASCO 2004). Primary objective: effects of AA+P on QT/QTc interval duration in mCRPC pts receiving LHRHa. Secondary objectives: pharmacokinetics (PK) of AA and abiraterone (A) after single/multiple doses of AA. Methods: In this open-label, single-arm phase 1b study (COU-AA-006/NCT00910754), 33 mCRPC pts with disease progression after failure of GnRH hormone therapy, a PSA ≥2 ng/mL and ≤1 course of prior chemotherapy, received AA 1000mg orally QD + P 5mg orally BID. ECGs were collected in triplicate using 12-lead Holter monitoring. Baseline ECGs were obtained on Cyc...
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Oral findings of 42 Mexican AIDS patients with cancer were reviewed. Kaposi's sarcoma (KS) was the most frequent malignancy (81%) followed by... more
Oral findings of 42 Mexican AIDS patients with cancer were reviewed. Kaposi's sarcoma (KS) was the most frequent malignancy (81%) followed by non-Hodgkin's lymphoma (NHL) (12%). All cases of NHL were of high or intermediate grade and most of them were extranodal. Out of the 34 individuals with KS, 22 (65%) showed oral KS and in 21 of them the palate was involved. The clinical features of oral KS including site, appearance and size are described. Pseudomembranous candidosis (PC), hairy leukoplakia (HL) and exfoliative cheilitis (ECh) were also found in these patients. There was no association of these lesions with any type of cancer. A strong association of oral candidosis and history of this infection was found, RR = 7.0 (1.3-4.1). There was evidence of severe immunosuppression in most patients, with mean average CD4 counts of 116 mm3 (range 4-841/mm3). Oral KS, ECh, PC and HL were more common in patients with lower CD4 counts. Our findings illustrate the most frequent oral lesions associated with HIV-1 infection in patients with AIDS and cancer, and further support the importance of oral examination in HIV infected patients.
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Research Interests: Pharmacokinetics, Clinical Pharmacology, Medicine, Prodrugs, Humans, and 15 moreKidney, Liver, Male, Suspensions, Aged, Middle Aged, Adult, Tablets, Chronic Kidney Failure, Renal Dialysis, Severity of Illness Index, Tolerability, Abiraterone acetate, renal insufficiency, and Pharmacology and pharmaceutical sciences
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Research Interests: English language, Health Care, Implementation Science, Health Management, Quality Improvement, and 15 moreHealth Services Research, Health Administration, Medicine, Risk factors, Production and Operations Management, Medline, Systematic review, Implementation, Cost Saving, Study design, Risk Factors, English Language, Keyword Search, Indexation, and Medical and Health Sciences
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OBJECTIVE To determine whether fetal ultrasound early in the third trimester can identify Latina with mild gestational diabetes mellitus (GDM) whose fetuses are at risk for macrosomia and, if so, whether maternal insulin therapy can... more
OBJECTIVE To determine whether fetal ultrasound early in the third trimester can identify Latina with mild gestational diabetes mellitus (GDM) whose fetuses are at risk for macrosomia and, if so, whether maternal insulin therapy can reduce that risk. RESEARCH DESIGN AND METHODS Study subjects included 303 consecutive women with GDM and a fasting serum glucose level <5.8 mM on diet therapy who had a fetal ultrasound between 29 and 33 weeks gestation. Of the women, 98 (32%) had a fetal AC ≥ 75th percentile for gestational age, and 59 women completed a randomized trial of diet therapy (n = 29) or diet plus twice daily insulin (n = 30). Maternal nutrient levels were assessed by meal tolerance testing (MTT) before and during therapy and by capillary glucose monitoring four to seven times a day. Birth weights corrected for gestational age and neonatal glycemia and skin folds were the primary outcome variables compared between treatment groups. RESULTS Diet and diet-plus-insulin groups ...
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Asthma and gastroesophageal reflux disease (GERD) often coexist. However, the results of the studies investigating the prevalence of GERD among patients with asthma vary greatly. To investigate the prevalence of GERD in adult patients... more
Asthma and gastroesophageal reflux disease (GERD) often coexist. However, the results of the studies investigating the prevalence of GERD among patients with asthma vary greatly. To investigate the prevalence of GERD in adult patients with asthma. The basic study population consisted of 2,225 asthmatic patients who were treated in six specialist-headed hospitals during 1 year. From the common computer-based discharge register, every 14th patient was randomly selected for the study. Ninety of the 149 contacted patients (60%) agreed to participate in the study. Twenty-four-hour esophageal pH monitoring was performed on all patients. GERD was found in 32 of the patients (36%). Eight of these patients (25%) were free from classical reflux symptoms. Forty-seven of the 90 patients (52%) presented with typical reflux symptoms. Twenty-four of these patients (51%) were found to have abnormal acidic reflux. According to the current study, one third of adult patients with asthma have GERD. These patients often do not have typical reflux symptoms. However, the presence of typical reflux symptoms in an asthmatic patient does not seem to guarantee the presence of abnormal acidic reflux.
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Abstract In our recent work on the C+(2 P)+ H 2→ CH++ H reaction, we did not consider a recent experimental cross section that disagrees with our calculated value. A simplified evaluation of a diabatic contribution to the reaction shows... more
Abstract In our recent work on the C+(2 P)+ H 2→ CH++ H reaction, we did not consider a recent experimental cross section that disagrees with our calculated value. A simplified evaluation of a diabatic contribution to the reaction shows its magnitude to be very small. ...
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Este estudo teve como objetivo identificar as características das práticas de atenção psicológica de pacientes com psicose. Usamos uma abordagem descritiva dentro da tradição qualitativa. Como categorias de análise se criaram avaliação,... more
Este estudo teve como objetivo identificar as características das práticas de atenção psicológica de pacientes com psicose. Usamos uma abordagem descritiva dentro da tradição qualitativa. Como categorias de análise se criaram avaliação, intervenção e ...
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In 2003, the National Institutes of Health (NIH) created a translational science funding stream to foster widespread, practice-based dissemination of scientific evidence. A decade later, our study of a national cohort of innovative... more
In 2003, the National Institutes of Health (NIH) created a translational science funding stream to foster widespread, practice-based dissemination of scientific evidence. A decade later, our study of a national cohort of innovative practices suggests that effective dissemination continues to be prevented by the limited biomedical focus of funded research, conventional research strategies, and failure to report contextual factors.
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Abiraterone acetate, the prodrug of the cytochrome P450 C17 inhibitor abiraterone, plus prednisone is approved for treatment of metastatic castration-resistant prostate cancer. We explored whether abiraterone interacts with drugs... more
Abiraterone acetate, the prodrug of the cytochrome P450 C17 inhibitor abiraterone, plus prednisone is approved for treatment of metastatic castration-resistant prostate cancer. We explored whether abiraterone interacts with drugs metabolized by CYP2C8, an enzyme responsible for the metabolism of many drugs. Abiraterone acetate and abiraterone and its major metabolites, abiraterone sulfate and abiraterone sulfate N-oxide, inhibited CYP2C8 in human liver microsomes, with IC50 values near or below the peak total concentrations observed in patients with metastatic castration-resistant prostate cancer (IC50 values: 1.3-3.0 µM, 1.6-2.9 µM, 0.044-0.15 µM, and 5.4-5.9 µM, respectively). CYP2C8 inhibition was reversible and time-independent. To explore the clinical relevance of the in vitro data, an open-label, single-center study was conducted comprising 16 healthy male subjects who received a single 15-mg dose of the CYP2C8 substrate pioglitazone on day 1 and again 1 hour after the adminis...
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Las enfermedades ampollosas autoinmunitarias constituyen, en algunas ocasiones, un reto diagnóstico debido al amplio espectro de afecciones que comparten características clínicas similares. Se comunica el caso de una paciente que ingresó... more
Las enfermedades ampollosas autoinmunitarias constituyen, en algunas ocasiones, un reto diagnóstico debido al amplio espectro de afecciones que comparten características clínicas similares. Se comunica el caso de una paciente que ingresó con un supuesto diagnóstico de reacción medicamentosa severa tipo síndrome de Stevens-Johnson, en la que sus antecedentes personales, perfil de autoinmunidad y aproximación interdisciplinaria fueron de vital ayuda para establecer el diagnóstico final.
Research Interests: Autoimmunity and Medicine
Se presenta un análisis de los problemas referidos a la ausencia de la enseñanza y por consiguiente de la evaluación de la oralidad en los ciclos 3, 4 y 5 de escuelas públicas de Bogotá. Se referencian investigaciones que con propósitos e... more
Se presenta un análisis de los problemas referidos a la ausencia de la enseñanza y por consiguiente de la evaluación de la oralidad en los ciclos 3, 4 y 5 de escuelas públicas de Bogotá. Se referencian investigaciones que con propósitos e instrumentos diversos se acercan a su evaluación. A partir de observaciones y de registros de clase, se analizan las prácticas de enseñanza y de evaluación dominantes. Se reafirma la problemática en el sentido de la carencia de instrumentos y estrategias para su enseñanza y evaluación.
Research Interests: Philosophy, Humanities, Speaking, Listening, Oral assessment, and 4 moreEnunciacion, Escucha, Enunciación, and Habla
This research study shows how writing as a school practice can be improved through metacognition using a pedagogical approach to meet students’ interests and promote interaction and team work through pedagogical projects. Written language... more
This research study shows how writing as a school practice can be improved through metacognition using a pedagogical approach to meet students’ interests and promote interaction and team work through pedagogical projects. Written language is approached via real situations of students’ everyday life through the “classroom project” where every activity undertaken has relevance and meaning. It required from the writers the use and management of particular cognitive and metacognitive skills to appropriate the characteristics of each of the texts written. Consequently, the quality of writing increased significantly due to a reflective process about the importance of gradually improving drafts by taking into account guidance from the teacher and contributions of the students. Through this exercise, students identified the narrative, expository, argumentative texts and their characteristics through knowledge gained by reading, analyzing and writing texts within those categories.
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ABSTRACT
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Studies on the protective efficacy of insecticide-treated materials (ITMs) in Plasmodium vivax endemic areas of Latin America have not yielded sufficient evidence for recommendation of their extensive use in the region. Therefore 2... more
Studies on the protective efficacy of insecticide-treated materials (ITMs) in Plasmodium vivax endemic areas of Latin America have not yielded sufficient evidence for recommendation of their extensive use in the region. Therefore 2 randomized community trials have been conducted on the Pacific Coast of Nicaragua which analysed the minimum coverage of ITMs needed to be effective against malaria. For the characterization of the study area, epidemiological and entomological baseline surveys and household interview surveys were undertaken. Thereafter the communities were paired (6 pairs in the 1st year and 13 pairs in the 2nd year) according to 4-monthly reported malaria incidence rates, population size and bednet coverage, and then randomly allocated to intervention and control groups. In the intervention groups, bednets were impregnated with lambdacyhalothrin; in the control groups, people received general health education. Anopheles albimanus was found to be the main vector with marked indoor biting behaviour late in the evening. P. vivax (99%) clearly outweighed P. falciparum (1%) with low parasite prevalence rates in the asymptomatic general population (8%) and low parasite densities. The protective efficacy of ITMs varied according to the coverage achieved: protective efficacy was 68% in communities with an average ITM coverage of 50% (10 pairs); 31% in communities with an ITM coverage of 16-30% (4 pairs); and no protective efficacy in communities with ITM coverage below 16% (5 pairs). The comparison with other P. vivax endemic areas in Latin America showed that the vector&#39;s late biting behaviour and the indoor preference (where ITMs have a repellent effect) probably led to the favourable results in the study. In malaria endemic areas of Latin America, where P. vivax is predominant, studies on vector behaviour should be conducted in order to predict the impact of ITMs on malaria transmission.
Research Interests: Environmental Health, Adolescent, Insecticides, Latin America, Humans, and 15 moreChild, Anopheles, Female, Animals, Infant, Incidence, Group Intervention, General Health, Cost Benefit Analysis, Cross Sectional Studies, General Population, Control Group, Insect Vectors, Child preschool, and Incidence Rate
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Research Interests: Research Methodology, Primary Health Care, Colombia, Health Education, Malaria, and 15 moreDeveloping Countries, Health, Ecuador, Medicine, Knowledge, Attendance, Rural Health, Humans, Nicaragua, Comparative studies, Questionnaires, Public health systems and services research, Intervention study, Community Based Mental Health Services, and Community health services
ABSTRACT Abstract L-usnic acid inactivates urease by the formation of high molecular weight aggregates which can reach a maximum of 700,000 under experimentation conditions previously described. The substrate, urea, itself provokes... more
ABSTRACT Abstract L-usnic acid inactivates urease by the formation of high molecular weight aggregates which can reach a maximum of 700,000 under experimentation conditions previously described. The substrate, urea, itself provokes temporary aggregation states which may be either active or inactive; the latter being reversible. However, these inactive aggregates, of 820,000 molecular weight, are irreversibly stabilized by L-usnic acid. The active aggregates with molecular weights oscillating from 605,000 to 650,000, depending on whether they are formed in the presence or absence of inactivator, may combine with the substrate to form an apparently normal ES complex.
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We start a controlled clinical trial to assess efficacy and toxicity of EBVD (epirubicin, bleomycin, vinblastine and dacarbazine) with an intensive and brief program of seven drugs administered weekly for 12 weeks in previously untreated... more
We start a controlled clinical trial to assess efficacy and toxicity of EBVD (epirubicin, bleomycin, vinblastine and dacarbazine) with an intensive and brief program of seven drugs administered weekly for 12 weeks in previously untreated patients with advanced ...