Research Interests: Genetics, Molecular Evolution, Biology, Virology, Medicine, and 15 moreBiological Sciences, Phylogeny, Cercopithecus aethiops, Humans, Animals, Infant, Genome, Capsid, Amino Acid Sequence, Hemorrhage, Vero cells, Nucleotides, Molecular Sequence Data, Nucleotide sequence, and Medical and Health Sciences
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To eradicate poliomyelitis and poliovirus, intensive vaccination campaigns with oral polio-vaccine (OPV) have been organised. Eradication campaigns may well be successful because the antiviral immunity and the local intestinal immunity... more
To eradicate poliomyelitis and poliovirus, intensive vaccination campaigns with oral polio-vaccine (OPV) have been organised. Eradication campaigns may well be successful because the antiviral immunity and the local intestinal immunity due to OPV in particular avoids and/or limits poliovirus circulation. These campaigns give interesting opportunities for studying the impact of viral vaccines on the viral world in terms of ecological and genetic virology. The pre-eradication phase we are now entering brings with it two kinds of problems. First, the major disadvantage of OPV is the genetic and phenotypic variability of the vaccine strains. This variability leads to the spread of potentially pathogenic strains, which can be implicated in vaccine-associated paralytic poliomyelitis (VAPP). Genetic changes are characterised by point mutations and by genetic exchanges among OPV strains, between OPV and wild strains and perhaps between poliovirus and non-polio enteroviruses (ENPV). The fact...
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Echovirus 11' (prime) isolates from an epidemic of haemorrhagic syndrome in departments of obstetrics in Hungary have been characterised. The leading component of the clinical disease was carditis and its lethal outcome occurred in 13... more
Echovirus 11' (prime) isolates from an epidemic of haemorrhagic syndrome in departments of obstetrics in Hungary have been characterised. The leading component of the clinical disease was carditis and its lethal outcome occurred in 13 newborn babies. Maternal immunity was found to be absent even in women of 41 years of age. The application of monovalent oral poliovirus type 1 vaccine prevented the progress of the epidemic within two weeks. Nevertheless, a serological survey among primovacinees of 3-15 months of age revealed that 20% of the babies seroconverted without clinical symptoms during the epidemic. Serological evidence showed that the echovirus 11' infection was unable to interfere with the efficacy of oral poliovirus vaccine (OPV), since seroconversion rates of primovaccinees did not differ significantly from those in the group seroconverted also to echovirus 11' during the vaccination campaign. A 440 nucleotide (nt) fragment of the 5'-non-translated region ...
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Research Interests: Genetics, Molecular Evolution, Biology, Virology, Medicine, and 15 moreBiological Sciences, Phylogeny, Cercopithecus aethiops, Humans, Animals, Infant, Genome, Capsid, Amino Acid Sequence, Hemorrhage, Vero cells, Nucleotides, Molecular Sequence Data, Nucleotide sequence, and Medical and Health Sciences
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Research Interests: Structure, RNA, Biology, Polyadenylation, Medicine, and 15 moreBiological Sciences, Humans, Sequence alignment, Alternative splicing, Nmr Structure, CHEMICAL SCIENCES, Protein Secondary Structure Prediction, Alternative Splicing, Molecular weight, Mechanism of action, Amino Acid Sequence, Protein Binding, Structure Determination, Full Length Movies, and Dimerization
Research Interests: Biochemistry, Thermodynamics, RNA, Biology, Medicine, and 11 moreHumans, Protein Secondary Structure Prediction, Solutions, RNA-binding proteins, Protein Conformation, Amino Acid Sequence, Solution Structure, Translation initiation, Biochemistry and cell biology, Molecular Sequence Data, and Medical biochemistry and metabolomics
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Research Interests: Genetics, Biology, Medicine, Functional Genomics, Crystal structure, and 15 moreCercopithecus aethiops, Humans, Animals, Homo Sapiens, Long Range, Biological evolution, Glycosylation, Clinical Sciences, Macaca Mulatta, Genome sequence, Amino Acid Sequence, Gtp Binding Proteins, Dimerization, binding sites, and Cricetinae
Family members of 47 hepatitis B virus (HBV)‐carrier pregnant women were tested for the presence of hepatitis B surface antigen (HBsAg), other markers of HBV infection, and hepatitis A virus (HAV) antibodies. Eleven members of six... more
Family members of 47 hepatitis B virus (HBV)‐carrier pregnant women were tested for the presence of hepatitis B surface antigen (HBsAg), other markers of HBV infection, and hepatitis A virus (HAV) antibodies. Eleven members of six families were found to be HBV DNA positive. Five of the anti‐HBe‐positive persons were found to be HBV DNA carriers, too. The mean age of the HBV DNA carriers was found to be lower than that of Hbe carriers; therefore, it is suggested that seroconversion to HBe occurs before the resolution of HBV DNA carrier state. Superinfection with hepatitis A virus was not found to influence the elimination of HBV‐carrier state, as there was no correlation found between the hepatitis A exposure and the hepatitis B virus markers in the families. The low HBV prevalence in the population (0.3%) was in contrast to the high prevalence of the families of the HBV‐carrier mothers (27.1%) and family members with HBV markers (50.4%). Significant positive correlation was found in...
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Research Interests:
... Tél:33 1 40 61 33 22 ;delpeyro@pasteur.fr * Groupe d'étude entérovirus : Oprisan G, Aubert Combiescu A , Combiescu M, Otelea D-Institut ... En effet, l'ana-lyse des souches issues de patients atteints de PPAV met en évidence... more
... Tél:33 1 40 61 33 22 ;delpeyro@pasteur.fr * Groupe d'étude entérovirus : Oprisan G, Aubert Combiescu A , Combiescu M, Otelea D-Institut ... En effet, l'ana-lyse des souches issues de patients atteints de PPAV met en évidence une p ro po rtion considérable de génomes ...
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The fibre gene of the bovine adenovirus type 2 (BAdV2) subtype B was prepared for sequencing by using cloning, sub-cloning and PCR amplification techniques. The nucleotide sequence of the total fibre gene was determined, and it was found... more
The fibre gene of the bovine adenovirus type 2 (BAdV2) subtype B was prepared for sequencing by using cloning, sub-cloning and PCR amplification techniques. The nucleotide sequence of the total fibre gene was determined, and it was found to consist of 1,647 nucleotides, coding for a polypeptide of 549 amino acids. The fibre gene regions of BAdV2 A and B subtypes were aligned. The nucleotide identity of the total fibre gene was found to be 60.5%; however, the homology showed great differences in the different subregions coding for the shaft and knob part of the fibre, and the two subtypes were almost identical in the tail subregion. Remarkable changes indicating deletion, insertion and point mutations were found in the shaft subregion when BAdV2/A and B subtypes were compared. We concluded that the differences found in the haemagglutinating activity of the two subtypes of BAdV2 can mostly be explained by the changes in the polypeptide structure of the fibre shaft.