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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Research Interests: Chemistry and Schiff Base
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Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 2 and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile 11, which were... more
Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 2 and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile 11, which were utilized as starting products for the synthesis of S-nucleoside analogues 10 and 15 and C-nucleoside analogues 12 and 13, is presented in the current study. The antibacterial and antifungal activities of these new compounds were evaluated. The structures of the new products were confirmed on the basis of elemental and spectral analysis results.
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The Michael addition of the 3‐N‐aryl‐carbamidocoumarins (III) with the ketones (IV), (VI), (VIII), and (X) is examined under various reaction conditions.
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Diaryl-oxiran-2-yl methanones (2) were prepared and reacted with thiourea to give 2-thioxo-tetrahydro-pyrimidine-5(2H)-ones (3).The latter compounds reacted with bromoacetic acid to afford the title compounds (4). Also some new... more
Diaryl-oxiran-2-yl methanones (2) were prepared and reacted with thiourea to give 2-thioxo-tetrahydro-pyrimidine-5(2H)-ones (3).The latter compounds reacted with bromoacetic acid to afford the title compounds (4). Also some new derivatives were prepared from the reaction of compounds (3) and (4) with different reagents. Compounds (3) were glycosidated with 2,3,4,6-tetra-O-acetyl-α -D-glucopyranosylbromide (α -ABG) to afford the corresponding nucleosides.
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String of vanadium (IV), zirconium (IV), palladium (II), platinum (IV) and uranium (VI) chelates of 2‐cyano‐2‐[(2‐nitrophenyl)hydrazono]thioacetamide (Cnphta) were prepared and characterized by physicochemical, spectroscopic and thermal... more
String of vanadium (IV), zirconium (IV), palladium (II), platinum (IV) and uranium (VI) chelates of 2‐cyano‐2‐[(2‐nitrophenyl)hydrazono]thioacetamide (Cnphta) were prepared and characterized by physicochemical, spectroscopic and thermal analyses. The formulae of the isolated solid complexes were assigned as [VO(Cnphta)2(H2O)]SO4 ⋅ 5H2O (1), [ZrO(Cnphta)2(H2O)]Cl2 ⋅ 4H2O (2), [Pd(Cnphta)2]Cl2 (3), [Pt(Cnphta)2Cl2]Cl2 (4) and [UO2(Cnphta)2](NO3)2 ⋅ 5H2O (5). The infrared assignments clearly showed that Cnphta ligand coordinated as a bidentate feature through the hydrazono nitrogen and the thioacetamide nitrogen for V(IV), Zr(IV) and U(VI) but displayed different behavior for Pd(II) and Pt(IV). Results of the molar conductivities measurements showed that the metal complexes were electrolytes in contrast with Cnphta ligand. The interpretation, mathematical analysis and evaluation of kinetic parameters were also carried out. In addition, the studied ligand and its new chelates were tested for their antimicrobial activity against some human or phytopathogenic microorganisms. The new metal complexes explicated promising antibacterial activity against all tested bacteria especially Staphylococcus aureus and Bacillus subtilis. Regarding the antifungal activity, all metal complexes were able to inhibit the mycelium growth of both tested pathogenic fungi. In particular Zr(IV) and Pt(IV) complexes showed the highest significant fungicidal effect against A. fumigatus similar to positive control.
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Thiswork presents a systematic and comprehensive survey on the chemical reactivity of 1,3-Bis (4-chlorophenyl)-2,3-epoxypropanone. This compound is important intermediates for the synthesis of a variety of otherwise difficult to obtain... more
Thiswork presents a systematic and comprehensive survey on the chemical reactivity of 1,3-Bis (4-chlorophenyl)-2,3-epoxypropanone. This compound is important intermediates for the synthesis of a variety of otherwise difficult to obtain synthetically useful and novel cyclic systems (2-12). The structure of the prepared products was elucidated by elemental and spectroscopic data. Moreover, the antimicrobial activity of prepared compounds has also been assessed and compound (11) revealed activity compared to the activity of the commonly used antimicrobial drug.
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2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide (<b>4</b>) was synthesized by reaction of 3-hydrazonoindolin-2-one (<b>3</b>) with phenyl isothiocyanate in DMF in presence of potassium hydroxide. Thus,... more
2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide (<b>4</b>) was synthesized by reaction of 3-hydrazonoindolin-2-one (<b>3</b>) with phenyl isothiocyanate in DMF in presence of potassium hydroxide. Thus, treatment of <b>4</b> with the appropriate halo ketones, hydrazonoyl halides, and benzylidene malononitriles afforded thiazolidin-4-one, and thiadiazole derivatives. Moreover, structures of the newly synthesized compounds were elucidated as based of elemental analysis and spectral data. Also, the influence of gamma irradiation on the biological activities of the new compounds was evaluated.
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Abstract Two series of tetrazole derivatives of the type N-(1H-tetrazol-5-yl)-1-(aryl)methanimine (101–106) and 1-(4-alkoxyphenyl)-N-(1H-tetrazol-5-yl)methanimine (107–111) were synthesized and characterized via conventional tools of... more
Abstract Two series of tetrazole derivatives of the type N-(1H-tetrazol-5-yl)-1-(aryl)methanimine (101–106) and 1-(4-alkoxyphenyl)-N-(1H-tetrazol-5-yl)methanimine (107–111) were synthesized and characterized via conventional tools of analysis (elemental analysis, FT-IR and 1H NMR spectroscopy). These two synthesized series were biologically evaluated for their potentials against some microbial biofilm causing strains (micro bio-foulants). Biological activities were evaluated by MIC values and cell viability percentages of them. In case of compounds (107–111), 107 was the most potent antimicrobial one, where its MIC values were 10.666667 µg/ml; 12.82222 µg/ml and 21.43666 µg/ml for Staphylococcus aureus, Escherichia coli and Candida albicans respectively, whereas compound 106, (of group 101–106), MIC values were 16 µg/ml for all the tested microorganisms. Viability assay showed that 107 activity percentages were 96.99456%, 92.32886% and 89.09558% against Gm +ve bacteria, Gm −ve bacteria and yeast respectively, whereas 106 activity percentages were 95.255569%, 90.204675% and 86.710956% against Gm +ve bacteria, Gm −ve bacteria and yeast respectively. Two antimicrobial mode of actions were proposed and discussed depending on the two evaluated tetrazole groups.
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The synthesis and characterization of Mn (II), Fe (II), Co (II), Ni (II), Cu (II) and Zn (II) complexes with 3‐(bromoacetyl)coumarin (BAC) in presence of 1,10‐phenanthroline (Phen) were reported and described by elemental analysis, molar... more
The synthesis and characterization of Mn (II), Fe (II), Co (II), Ni (II), Cu (II) and Zn (II) complexes with 3‐(bromoacetyl)coumarin (BAC) in presence of 1,10‐phenanthroline (Phen) were reported and described by elemental analysis, molar conductivity, FT‐IR, UV–Vis and effective magnetic moments. TG and DTG have been applied to study the decomposition mechanisms for BAC, Phen and their complexes. The analytical results and spectral studies showed that BAC and Phen act as bidentate ligands via oxygen of α, β‐unsaturated ketone and oxygen of lactone carbonyl of coumarin and two pyridyl nitrogen atoms of Phen. Octahedral geometries have been proposed for all complexes and the kinetic parameter (E*, ΔH*, ΔS* and ΔG*) were calculated using Coats‐Redfern (CR) and Horowitz‐Metzeger (HM) methods. DFT calculations (bond lengths, bond angles, total energy, heat of formation, dipole moment and the lowest energy model structures) have been determined. The antibacterial activities for synthesize...
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Background: Thiazolopyrimidine analogues are versatile synthetic scaffold possessing wide spectrum of biological interests involving potential anticancer activity. Objective: To report the synthesis of novel bromothiazolopyrimidine... more
Background: Thiazolopyrimidine analogues are versatile synthetic scaffold possessing wide spectrum of biological interests involving potential anticancer activity. Objective: To report the synthesis of novel bromothiazolopyrimidine derivatives and the study of both molecular modeling and in-vitro anticancer activity. Methods: Novel bromothiazolopyrimidine derivatives 5-18 have been prepared from 2-bromo-3-(4- chlorophenyl)-1-(3,4-dimethylphenyl)-propenone 3 as a key starting compound. The anti-cancer activities of the new compounds were evaluated against HepG2, MCF-7, A549 and HCT116 cell lines. Results: The compounds 16, 17 and 18 showed cytotoxic and growth inhibitory activities on both colon and lung cells. The cytotoxic activities of the novel synthetic compounds 8, 9, 11, 16, 17 and 18 were due to CDC25 phosphatases inhibition as shown by the enzymatic binding assay. Although compounds 8, 9 and 11 have only demonstrated CDC25B phosphatases inhibition. Conclusion: The novel brom...
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A series of tosyl carbamates have been synthesized and screened for their antibacterial and antifungal activities. All the synthesized compounds were characterized by spectral techniques (IR, 1H, 13C NMR and mass) and elemental analysis.... more
A series of tosyl carbamates have been synthesized and screened for their antibacterial and antifungal activities. All the synthesized compounds were characterized by spectral techniques (IR, 1H, 13C NMR and mass) and elemental analysis. in silico Molecular docking method was performed to study their antimicrobial activity against the target protein 1T9U. Compound 27 showed good antibacterial activity against Gram-positive and Gram-negative bacterial strains and compound 19 showed good antifungal activity. Molecular docking results revealed that the compound 19 exhibits minimum CDOCKER energy. Tosyl carbamate derivatives having good antimicrobial activities compared to that standard and all the synthesized compounds exhibits moderate CDOCKER scores.
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Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f,... more
Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
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Some new phthalazinones such as (III) are prepared in order to test their antihypertensive activity.
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Die Cumarinsäurechloride (I) kondensieren mit Anthranil‐ Säure bei anschließender Behandlung mit Acetanhydrid zu den Benzoxazinylcumarinen (II), die sowohl sauer als auch alkalisch zu (III) gespalten werden können.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Trans, 10,11-dibromide Ic reacted with di- and triethyl phosphites to yield 5-hydroxy, 5-phosphonate II, while 5-oximes IIIa‒d gave 5-hydroxylamino-5-phosphonates IVa-d. Ic reacted with Na2S to give 10,11-sulphide V that reacted with... more
Trans, 10,11-dibromide Ic reacted with di- and triethyl phosphites to yield 5-hydroxy, 5-phosphonate II, while 5-oximes IIIa‒d gave 5-hydroxylamino-5-phosphonates IVa-d. Ic reacted with Na2S to give 10,11-sulphide V that reacted with hydrogen peroxide to yield the sulphone VI and with ethyl cyanoac-etate gave VII.
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Abstract A number of the compounds Me2RSnX (R neopentyl, 1-methylcyclohexyl; X Me, Cl, H) has been prepared for the first time. Generally, replacement of Me in a higher methylated precursor against Cl in polar medium by HgCl2 has been... more
Abstract A number of the compounds Me2RSnX (R neopentyl, 1-methylcyclohexyl; X Me, Cl, H) has been prepared for the first time. Generally, replacement of Me in a higher methylated precursor against Cl in polar medium by HgCl2 has been shown to be the best way to obtain the halides mentioned. The hydrides are used for ESR measurements of the corresponding stannyl radicals.
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Abstract In the present study newly developed potentiometric sensors for determination of zinc(II) are presented. The proposed potentiometric method was based on the fabrication of modified carbon paste (MCPE; electrode X) and modified... more
Abstract In the present study newly developed potentiometric sensors for determination of zinc(II) are presented. The proposed potentiometric method was based on the fabrication of modified carbon paste (MCPE; electrode X) and modified gold nanoparticles-carbon paste (GNPs-CPE; electrode IX) sensors. A mercapto compound of 1,4-bis(5-mercaptopentyloxy)-benzene (BMPB) alone or self-assembled on gold nanoparticles was used as modifier to construct electrode (X) and electrode (IX) sensors, respectively. The prepared electrodes exhibit Nernstian slope of 29.93 ± 0.4 and 26.0 ± 1.02 mV decade −1 towards Zn(II) ion over a wide concentration range of 6.8 × 10 −10 to 2.9 × 10 −2 and 1.0 × 10 −7 to 1.0 × 10 −2 mol L −1 for electrode (IX) and electrode (X) sensors, respectively. The limit of detection of the electrode (IX) and electrode (X) sensors was found to be 6.8 × 10 −10 and 1.0 × 10 −7 mol L −1 , respectively. The potentiometric response of the electrode (IX) and electrode (X) based on GNPs-BMPB and BMPB are independent of pH of test solution in the pH range of 2.5–8.1 and 3–7 with a response time of 6 and 8 s for electrode (IX) and electrode (X) sensors, respectively. The proposed sensors showed fairly good discriminating ability towards Zn(II) ion in comparison with many hard and soft metal ions. Finally, the proposed electrodes were successfully used as indicator electrodes in potentiometric titration of zinc ion with sodium tetraphenylborate (NaTPB) and in direct determination of Zn(II) ion in some water samples. The results obtained compared well with those obtained using atomic absorption spectrometry.
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ABSTRACT Here in, the nanostructure of dithiol surfactants were synthesized with gold nanoparticles (AuNPs). The nanostructure of these surfactants was investigated using FTIR, UV, XRD, and TEM techniques. The surfactants under... more
ABSTRACT Here in, the nanostructure of dithiol surfactants were synthesized with gold nanoparticles (AuNPs). The nanostructure of these surfactants was investigated using FTIR, UV, XRD, and TEM techniques. The surfactants under investigation show good ability for assembling on AuNPs. The alkyl chain length shows strong effect on the stabilization of the nanostructure of these surfactants. The detection of Ni2+ and Zn2+ ions in water solution was investigated using UV spectrophotometer. The data show that the sensitivity of the nanostructure of surfactants towards the detection of Ni2+ and Zn2+ ions is more than that of the individual surfactants.
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Pyridine and fused pyridines derivatives are interesting compounds with diverse chemical properties and pharmacological activities. Herein, the synthesis and antiviral evaluation of some new pyridines are described.
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In this work, we synthesized amino thiol surfactants, namely, 10-(4-aminophenoxy)-decane- 1-thiol and 12-(4-aminophenoxy)-dodecane-1-thiol. The self-assembling of the synthesized surfactants on gold nanoparticles (AuNPs) was investigated... more
In this work, we synthesized amino thiol surfactants, namely, 10-(4-aminophenoxy)-decane- 1-thiol and 12-(4-aminophenoxy)-dodecane-1-thiol. The self-assembling of the synthesized surfactants on gold nanoparticles (AuNPs) was investigated using different techniques such as ultraviolet analysis, x-ray diffraction, and transmission electron microscopy. The synthesized surfactants show the ability to assemble on gold nanoparticles and form stable nanostructure with it. We used the synthesized surfactants and their nanostructures with gold nanoparticles for the detection of Zn and Ni ions in aqueous solution using the ultraviolet spectrophotometer technique. The synthesized amino thiol surfactants showed the ability to detect Zn and Ni ions at low concentration. The results showed that gold nanoparticles can enhance the detection of Zn and Ni ions using the nanostructures of the synthesized surfactants.
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ABSTRACT Methylierte Phenylreste in Hexaaryldistannanen führen dann zur reversiblen thermischen Dissoziation R3Sn–SnR3 (1) ⇋ 2 R3Sn. (2), wenn mindestens die 2,6-Positionen methyliert sind. Weitere Methylgruppen erleichtern dies nur, wenn... more
ABSTRACT Methylierte Phenylreste in Hexaaryldistannanen führen dann zur reversiblen thermischen Dissoziation R3Sn–SnR3 (1) ⇋ 2 R3Sn. (2), wenn mindestens die 2,6-Positionen methyliert sind. Weitere Methylgruppen erleichtern dies nur, wenn sie benachbart dazu und untereinander stehen, also einen „Stütz-Effekt” ausüben. In Abhängigkeit dazu sinkt DSn–Sn (51.5→38.5 kcal/mol). ESR-Daten und Geometrie von 2 werden angegeben, ebenso der aus dem jeweiligen Hydrid R3SnH gewonnenen Stannylradikale 2 mit R = PhmMenCCH2 (m + n = 3). Bei diesen wird mit steigendem m die Rotation um die CSn-Bindung gehindert. Die bevorzugte Konformation folgt aus ESR-Daten. Zahlreiche Verbindungen 1, R3SnH sowie weitere Vorprodukte werden erstmals dargestellt.Sterically Hindered Free Radicals, IX. Generation and Structure of Stannyl Radicals R3Sn˙ with Bulky GroupsMethylated phenyl groups in hexaaryldistannanes cause reversible thermal dissociation R3SnSnR3 (1) ⇋ 2 R3Sn˙ (2) only if at least the 2,6-positions are methylated. Further methyl groups enhance this dissociation only when neighbouring these positions and each other, thus causing a “buttressing effect”. So, DSnSn is decreased (51.5 → 38.5 kcal/mol). ESR data and geometry of 2 are reported, as well as those of stannyl radicals 2, R = PhmMenCCH2 (m + n = 3) generated from the corresponding hydrides. The rotation around CSn bonds is hindered with increasing m. A preferred conformation is concluded from ESR data. Numerous compounds 1, R3SnH, and other precursors are prepared for the first time.
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Studies on coumarin derivatives. 6,8-Di-tert-butyl-4-phenyl-3,4-dihydrocoumarin (I) was obtained by Pechmann condensations of 2,4-di-tert-butyl-phenol with cinnamic acid in presence of 70% H 2 SO 4 . A series of derivatives of I was... more
Studies on coumarin derivatives. 6,8-Di-tert-butyl-4-phenyl-3,4-dihydrocoumarin (I) was obtained by Pechmann condensations of 2,4-di-tert-butyl-phenol with cinnamic acid in presence of 70% H 2 SO 4 . A series of derivatives of I was prepared
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ABSTRACT The synthesis of novel bulky tris[dimethyl(ethyl/benzyl/p-tolyl/α-naphthyl)silylmethyl]stannanes (1–4) is described. Alkylation of SnCl4 with Me2(ethyl/p-tolyl)SiCH2MgBr (10–11) gave mainly the triorganotin chlorides... more
ABSTRACT The synthesis of novel bulky tris[dimethyl(ethyl/benzyl/p-tolyl/α-naphthyl)silylmethyl]stannanes (1–4) is described. Alkylation of SnCl4 with Me2(ethyl/p-tolyl)SiCH2MgBr (10–11) gave mainly the triorganotin chlorides [(Me2(ethyl/p-tolyl)SiCH2)]3SnCl 14 and 15, which were isolated by silica gel chromatography. Reduction of 14 and 15 with LiAlH4 in THF gave the corresponding triorganotin hydrides 1 and 2, respectively. [Me2(benzyl/α-naphthyl)SiCH2]3SnCl 16 and 17, generated by the alkylation of SnCl4 with Me2(benzyl/α-naphthyl)SiCH2MgBr 12 and 13, were inseparable from the minor product [Me2(benzyl/α-naphthyl)SiCH2]2SnCl218 and 19, respectively. Treatment of the mixtures of 16/18 and 17/19 with NaOH furnished the corresponding mixtures of stannoxanes, from which the hexakisdistannoxanes [Me2(benzyl/α-naphthyl)SiCH2]6Sn2O 20 and 22 were isolated from the minor dialkyltin oxide derivatives [Me2(benzyl/α-naphthyl)SiCH2]2SnO in good yields. Reduction of 20 and 22 with BH3 in THF gave [Me2(benzyl/α-naphthyl)SiCH2]3SnH (3 and 4), respectively in good yields. 1H, 13C, 119Sn, 29Si NMR characteristics of the newly synthesized compounds are included.