Pyrimidine

The regulatory effect of derivatives of pyrimidine - Methyur and Kamethur, and pyridine - Ivin on the growth and development of winter barley (Hordeum vulgare L.) cultivar Svitozar was investigated in laboratory conditions. It was found that the morphometric parameters of the 6-week-old barley seedlings grown on water solution of Methyur, Kamethur and Ivin used at the concentration 10-8M, exceeded the morphometric parameters of plants grown on distilled water (control). The positive effect of Methyur, Kamethur and Ivin on the increase of the content of key indicators of productivity of barley plants – the photosynthetic pigments and total soluble proteins was found. The obtained results confirmed the possibility of application of pyrimidine and pyridine derivatives as new effective growth regulators of the winter barley (Hordeum vulgare L.) cultivar Svitozar.

The regulating activity of synthetic LMWHC, derivatives of pyrimidine on growth of tomato (Solanum lycopersicum L.) cultivar Fakel during the 8 weeks was studied. It was found that the derivatives of pyrimidine used at the concentration 10-9M demonstrated auxin-like plant growth regulating activity, which was similar or higher than the activity of plant hormones auxins IAA (1H-Indol-3-ylacetic acid) and NAA (1-Naphthylacetic acid). The morphometric parameters of 8th-week-old tomato seedlings grown in perlite moistened with solutions of synthetic LMWHC, derivatives of pyrimidine used at the concentration 10-9M were similar or higher to the similar parameters of 8th-week-old tomato seedlings grown either in perlite moistened with distilled water (control) or solutions of plant hormones auxins IAA and NAA used at the same concentration 10-9M on average: to 21 - 30 % - for length of the shoots, to 8 - 80 % - for average shoot mass, to 10 - 20 % - for length of the main root, to 10 – 46 % - for average root mass, respectively. . The plant growth regulating activity of synthetic LMWHC, derivatives of pyrimidine was varied depending on different substituents in their chemical structure.
Among tested compounds the highest growth regulating activity showed the compound 6-(Methanesulfonyl)imidazo[1,2-a]pyrimidin-5-ylamine, which belongs to derivatives of dihydroimidazo[1,2-c]pyrimidine containing methylsulfonyl group in the 6 position of dihydroimidazo[1,2-c]pyrimidine, and the compound Diethyl [4-(benzylamino)-5-(4- methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]phosphonate, which belongs to derivatives of pyrrolo[3,2- d]pyrimidine containing benzylamino substituent in the 4 position and 4-methylphenyl substituent in the 5 position of pyrimidine fragment. The high regulating activity showed the compounds, which belong to derivatives of dihydroimidazo[1,2-c]pyrimidine and pyrimido[1,6-a]pyrimidine. This fact is explained by the presence of various substituents in their chemical structure: the compound  6-(2-Hydroxyethyl)-8- (methanesulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3H)-one hydrochloride contains hydroxyethyl group in the 6 position, the compound  2-[8-(Benzenesulfonyl)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidin- 6(5H)-yl]ethyl acetate contains 2-acetoxyethyl group in the 2 position, the compound 8-(Benzenesulfonyl)-6-(4-methylphenyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3H)-one contains 4-methylphenyl group in the 6 position, the compound  6-Benzyl-8-(methanesulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3H)-one contains 6-Benzyl group in the 6 position of dihydroimidazo[1,2-c]pyrimidine, the compound  9- (Methanesulfonyl)-7-propyl-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one does not contain any substituent in the 6 position, the compound  2-[9-(Methanesulfonyl)-6-oxo-3,4-dihydro-2H-pyrimido[1,6- a]pyrimidin-7(6H)-yl]ethyl acetate contains 2-acetoxyethyl group in the 2 position and methanesulfonyl group in the 9 position, the compound 2-[9-(benzenesulfonyl)-6-oxo-3,4-dihydro-2H-pyrimido[1,6-a]pyrimidin- 7(6H)-yl]ethyl acetate contains 2-acetoxyethyl group in the 2 position and benzenesulfonyl group in the 9 position, the compound 9-(Benzenesulfonyl)-7-(4-methylphenyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one contains 4-methylphenyl group in the 7 position and benzenesulfonyl group in the 9 position of the pyrimidine fragment. The obtained results proved the possibility of practical application of synthetic LMWHC, derivatives of pyrimidine as new effective regulators for vegetative growth of tomato (Solanum lycopersicum L.) cultivar Fakel.
Key words: tomato (Solanum lycopersicum L.), plant growth regulators, synthetic low molecular weight heterocyclic compounds, derivatives of pyrimidine, auxins IAA and NAA.

Wheat (Triticum aestivum L.) is an important cereal crop cultivated in the most economically developed countries. The elaboration of new effective growth regulators for intensification of seed germination stage and vegetative growth of wheat is an actual problem for modern agriculture. This work was devoted to study of the regulating effect of chemical low molecular weight heterocyclic compounds, derivatives of [1,3]oxazolo[5,4-d]pyrimidine
and N-sulfonyl substituted of 1,3-oxazole on intensification of vegetative growth of wheat (Triticum aestivum L.) cultivar Zimoyarka. The growth regulating activity of derivatives of [1,3]oxazolo[5,4-d]pyrimidine and N-sulfonyl substituted of 1,3-oxazole was compared with activity of plant hormones auxins IAA (1H-Indol-3-ylacetic acid) and NAA(1-Naphthylacetic acid). The obtained results showed that all tested chemical compounds revealed expressive auxin-like plant growth regulating activity, which was similar or higher of the activity of auxins IAA and NAA. The growth parameters of roots and shoots of the 20th-day-old wheat seedlings cultivated in the water solution of the chemical heterocyclic compounds used at the concentration 10-9M were similar or higher of the growth parameters of wheat seedlings cultivated in the distilled water (control) orwater solution of auxins IAA and NAA used at the same concentration 10-9M. It was found that the plant growth regulating activity of tested chemical compounds varied according to different substituents in the chemical structure of heterocyclic compounds. The highest activity revealed the compound 5-(4-ethylphenyl)-2-phenyl[1,3]oxazolo[5,4-d]pyrimidin-7(6H)-one, which contains oxygen at the 7th position of pyrimidine fragment and compound 7-aminо-5-(4-ethylphenyl)-2-phenyl[1,3]oxazolo[5,4-
d]pyrimidine, which contains amino group at the 7th position of pyrimidine fragment of oxazole. Obviously, that plant growth regulating activity of compounds derivatives of [1,3]oxazolo[5,4-d]pyrimidine may be depended from substituents at the 5th and 7th positions of pyrimidine fragment. The obtained data confirmed the possibility of practical application of chemical heterocyclic compounds the derivatives of [1,3]oxazolo[5,4-d]pyrimidine and N-sulfonyl substituted of 1,3-oxazoles as new effective growth regulators in the cultivation of wheat (Triticum aestivum L.) cultivar Zimoyarka.

An efficient, simple and one-pot synthesis of pyrimidine derivatives by a three-component reaction of ketones, triethyl
orthoformate, and ammonium acetate in the presence of boron sulfuric acid as a reusable and efficient catalyst under solventfree
conditions is reported. The reusability of catalyst, simplicity of the starting materials, short reaction time, one-pot, and
good yields of products are the main advantages.

The effect of derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur) and N-oxide-2,6-dimethylpyridine (Ivin) on growth and productivity of various cultivars of grain sorghum (Sorghum bicolor (L.) Moench) and sweet sorghum (Sorghum saccharatum (L.) Moench) was studied. It was found that soaking seeds with water solutions of Methyur, Kamethur and Ivin used at a concentration of 10-7 M before sowing them into the soil contributed to improve the growth of sorghum and increase their productivity. The obtained results testify to the cultivar-dependent action of chemical compounds derivatives of pyrimidine and pyridine. The possibility of practical application of Methyur, Kamethur and Ivin as new effective regulators of sorghum growth is discussed.

An actual problem for the modern agrarian sector is the development of new growth regulators for important agricultural crop – pea (Pisum sativum L.) cultivated in different countries around the world. Currently, the growth regulators of natural
and synthetic origin are widely used in the agriculture to improve the growth and development of pea plants during the vegetation period and increase their yield. However, the great theoretical and practical interest is the elaboration of new ecologically safe plant growth regulators created on the base of low molecular weight five and six-membered heterocyclic compounds which are known to be used as a herbicides and plant growth regulating substances. The main aim of our work was to study the stimulating effect of low molecular weight heterocyclic compounds, derivatives of pyrimidine synthesized at the Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, on growth and development of pea (Pisum sativum L.) cultivar L35/11 middle stalwart bewhiskered
during the vegetative period. It was found that the biometric indices of 21-day-old pea seedlings grown on water solution of chemical compounds, derivatives of pyrimidine used at the concentration 10–8 M exceeded the biometric indices of control
plants grown on distilled water in average: at the 13–24 % – by the length of the main root, and at the 12–37 % – by total number of roots. The highest growth stimulating activity revealed the chemical compounds, derivatives of dihydroimidazo[
1,2-c]pyrimidine, their activity was differentiated depending on the substituents in their chemical structure. Obviously, that the high growth regulating activity of the investigated chemical compounds, derivatives of pyrimidine is explained by
their auxin-like and cytokinin-like stimulating action on the plant cell enlargement, proliferation and differentiation, which are the main processes of plant growth and development. The obtained results confirmed the possibility of the application in the agricultural practice of derivatives of pyrimidine used at the concentration 10–8 M to improve the growth and development of pea (Pisum sativum L.) cultivar L35/11 middle stalwart bewhiskered during the vegetation period.

A series of O4-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O6-cyclohexylmethylpurines, 2-arylaminopyrimidines with a sulfonamide or carboxamide group at the 4′-position were potent inhibitors, with IC50 values against CDK2 of 1.1±0.3 and 34±8 nM, respectively. The crystal structure of the 4′-carboxamide derivative, in complex with phospho-Thr160 CDK2/cyclin A, confirmed the expected binding mode of the inhibitor, and revealed an additional interaction between the carboxamide function and an aspartate residue.A series of O4-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O6-cyclohexylmethylpurines, 2-arylaminopyrimidines with a sulfonamide or carboxamide group at the 4′-position were potent inhibitors, with IC50 values against CDK2 of 1.1±0.3 and 35±8 nM, respectively. The crystal structure of the 4′-carboxamide derivative, in complex with phospho-Thr160 CDK2/cyclin A, confirmed the expected binding mode of the inhibitor, and revealed an additional interaction between the carboxamide function and an aspartate residue.

New  series  of  2-heterocycle-substituted  benzimidazole  having  a
pyrazolo  [3,  4-d]  pyrimidine  nucleus  have  been  synthesized  by
reacting  2-(chloromethyl)  benzimidazole  with  hydrazine  hydrate  to
form  compound  (1).  The  vital  compound  in  this  synthesis  1-((benzoimidazol-2-yl)methyl)-3-methyl-pyrazol-5-one was  obtained
by  reacting  compound  (1)  with  ethyl  acetoacetate,  and  was  used  in
the Biginelli multi-component cyclo condensation reaction with eight
derivatives of benzaldehyde in presence of urea  to  form pyrimidine
derivatives (3-10).
The products were characterized by C.H.N analyses,  I.R spectra and
1
HNMR spectrum.
Antibacterial activity of some prepared compounds against two types
of  bacteria: Staphylococcus  aureus (Gram  positive)  and
Pseudomonas  aeruginosa (Gram  negative).  Some  the  compounds
showed high inhibition activity against bacteria.

The purpose this research work is to determine the antibacterial and antifungal assay of partitioned fractions of S. mombin (Linn) extracts against clinical and environmental isolates. The root, leaf and stem-bark of S. mombin were harvested and air-dried. The dried S. mombin was milled into powdered form using manual grinder. Powdered S. mombin (1 kg) each of the different S. mombin parts was extracted with 3 L of 70% (v/v) ethanol, ethyl acetate and distilled water for 72 h at room temperature. The SMRE and SMREA were used to code for root part; SMLE and SMLEA for the leaf part; and SMSBE and SMSBEA for the stem-bark part, each was fractionated on column chromatography with silica as the stationary phase using n-hexane, ethyl acetate and ethanol as the eluting solvent to obtain n-hexane, ethyl acetate and ethanol fractions. Antimicrobial and antifungal screened was observed using agar well diffusion test. The result obtained showed that in partially purified ethyl acetate leaf extracts, Fraction (F 1 SMLEAH) showed significant inhibitory effect (p ≤ 0.05) on all the test bacteria, except Klebsiella pneumoniae and Salmonella typhi at concentrations of 20.0-2.5 mg/ml, Fraction (F 2 SMLEAEA) was not effective against Salmonella cholleraesuis, B. substilis, Citrobacter koseri and Salmonella typhi. Fraction (F 3 SMLEAE) showed little or no inhibitory effect on most of the bacteria at all the concentration used. It can be deduced that in partially purified ethanolic leaf extracts, Fraction (F 1 SMLEH) showed inhibitory effect on Burkholderia cepacia. All the organisms were not susceptible to all the fractions except F 1 which had diameter of zones of growth inhibition ranging between 4.0-1.0 mm at 5 mg/ml-0.625 mg/ml on Mycobacterium abscessus. Partially purified ethanolic stem bark extracts, antifungal activity of the partially purified ethanolic extracts of S. mombin, Fractions (F 1 SMLEH, F 2 SMLEEA) and F 3 SMLEE), significant antifungal activity (p ≤ 0.05) was observed at 20.0 mg/ml with most test fungi. Trichoderma horizionum was not susceptible to all the three fractions, while Aspergillus niger and Syncephala strumracemosum were susceptible to only fraction (F 2 SMLEEA). Fractions (F 1 SMSBEH, F 2 SMSBEEA), F 3 SMSBEE) on the test as the eluting solvent. Significant inhibitory effect (p ≤ 0.05) was observed in all the fractions at 20 mg/ml against most of the test bacteria. While, zones of growth inhibition of the various fractions varied with the test bacteria with the highest diameter zone of 8.0 mm recorded in fraction F 1 against Salmonella typhi. Fractions (F 2 SMSBEEA and F 3 SMSBEE) possessed significant inhibitory effect (p ≤ 0.05) at 20.0-5.0 mg/ml on the test fungi, except Candida kruise and Rhizopus stonifer. The plant part by solvent interactive effect was significant (p<0.05), suggesting that the MICs and MBCs of test bacteria were observed at 0.3125 and 0.1562 mg/ml and MICs and MFCs test fungal were observed at 0.3125 and 0.1562 mg/ml respectively, The various plants differ significantly according to extraction solvent, These findings demonstrate the possible effectiveness of the S. mombin plant, especially its stem bark extracts, in treating microbial infections.

The comparative analysis of the stimulating effect of low molecular weight heterocyclic compounds, derivatives of pyrimidine, pyrazole, isoflavones, pyridine, oxazolopyrimidine, oxazole and plant hormones auxins IAA (1H-Indol-3-ylacetic acid) and NAA (1-Naphthylacetic acid) on germination of seeds and growth of seedlings of flax (Linum usitatissimum L.) cultivars Ukrainian 3 and Svitanok was conducted. The specific auxin-like stimulating effect of chemical heterocyclic compounds on the basic processes of flax seedlings growth: cell division, cell proliferation, cell elongation and cell differentiation was found. The growth parameters of flax seedlings grown on water solution of chemical heterocyclic compounds used at the concentrations 10-8 M and 10-9 M were similar or higher of the growth parameters of flax seedlings grown on distilled water (control) or on water solution of auxins IAA and NAA used at the same concentrations 10-8 M and 10-9 M. The obtained results proved the possibility of practical application o f derivatives of pyrimidine, pyrazole, isoflavones, pyridine, oxazolopyrimidine and oxazole for intensification of vegetative growth of flax.
Keywords: Linum usitatissimum L., auxins IAA and NAA, pyrimidine, pyrazole, isoflavones, pyridine, oxazolopyrimidine, oxazole.

We report the synthesis, crystal structure and exfoliation of a new member of an important family of layered compounds: lamellar pyrimidinethiolate coordination polymers. Conductivity measurements and DFT calculations of iron(ii) pyrimidine-2-thiolate show that this material and a related compound are insulators.

New synthetic compounds — pyrimidine derivatives — were screened to select the most effective of them, which show a growth-regulating activity in plants. Their action was compared with phytohormones of the auxin class. In particular, the effect of synthetic compounds on the seed germination, growth, and development of tomato (Solanum lycopersicum L.) plants of Lagidny variety in vivo and in vitro was studied. It was found that some of the studied compounds have a positive effect on the morphometric and biochemical parameters of 30-day-old plants: compounds D1-D5 increased seed germination up to 9-27 %, the most effective among them was com-pound D1. Compounds D1 and D2 increased the height of the shoots up to 29 %. All the studied compounds effectively influenced the rooting of plants, increasing either the length of the roots (up to 8 %) or their number (up to 25 %), the most effective among them was the compound D2. The effect of these compounds on the mor-phogenetic potential of tomato explants was studied in vitro for the first time. It was found that compounds D1 and D2 were the most effective for the direct plant regeneration. Screened compounds can be further recommended for the use in various biotechnological programs for genetic improvement of tomatoes.
Keywords: synthetic compounds, pyrimidine derivatives, growth regulators, auxins, plants, Solanum lycopersicum L., in vivo, in vitro.

In an attempt to find a new class of antimicrobial and antitubercular agent, a new series of chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus were synthesized with appropriate chemical reagent. Chalcones (D1-D5) were synthesized by the classical Claisen-Schmidt condensation of substituted ketone (C) with variously substituted aldehydes via conventional method. Now treatment of chalcones with hydrazine hydrate/glacial acetic acid and guanidine hydrochloride/Alkali afforded the corresponding acetyl pyrazoline (E1-E5) and amino pyrimidine (F1-F5) derivatives respectively. The chemical structures of all newly synthesized compounds were established on the basis of their FTIR, 1H NMR, 13C NMR, LC-MS as well as elemental analysis. All the newly design compounds were assayed for their in vitro antimicrobial activity against selected pathogens by the Broth dilution method and in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using Lowen...

Key indicators: single-crystal X-ray study; T = 293 K; mean (C–C) = 0.002 A ˚ ; R factor = 0.048; wR factor = 0.140; data-to-parameter ratio = 20.4. In the title compound, C 15 H 18 N 2 O 5 ÁH 2 O, the pyrimidine ring adopts a flattened-boat conformation. The ethoxy group attached to the benzene ring is in an extended conformation. The oxopyrimidine molecules are linked into centrosymmetric R 2 2 (20) dimers by O—HÁ Á ÁO hydrogen bonds. The dimers are linked by N—HÁ Á ÁO hydrogen bonds, forming a two-dimensional network parallel to the bc plane. Adjacent networks are cross-linked via N—HÁ Á ÁO and O—HÁ Á ÁO hydrogen bonds involving the water molecules.

The formation of intermolecular DNA triple helices offers the
possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. In these structures a third strand oligonucleotide binds in the DNA major groove, making specific contacts with substituents on the exposed faces of the base pairs. Although triplexes form with exquisite specificity their use suffers from several drawbacks. Two limitations of this approach, which are considered in this review are, firstly that conditions of low pH are necessary for formation of the C+lGC triplet, and secondly that these structures are often less stable than their duplex counterparts. This review outlines the strategies that have been employed to overcome these drawbacks. The pH problem is addressed by considering the various DNA base analogues that have been used to recognise
GC base pairs in a pH independent fashion, and discusses the benefits and limitations of each analogue. Triplex stability can be increased by using novel base analogues, backbone modifications and the use of triplex-specific binding ligands.

In an attempt to find a new class of antimicrobial and antitubercular agent, a new series of chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus were synthesized with appropriate chemical reagent. Chalcones (D1-D5) were synthe...

In an attempt to find a new class of antimicrobial and antitubercular agent, a new series of chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus were synthesized with appropriate chemical reagent. Chalcones (D1-D5) were synthesized by the classical Claisen-Schmidt condensation of substituted ketone (C) with variously substituted aldehydes via conventional method. Now treatment of chalcones with hydrazine hydrate/glacial acetic acid and guanidine hydrochloride/Alkali afforded the corresponding acetyl pyrazoline (E1-E5) and amino pyrimidine (F1-F5) derivatives respectively. The chemical structures of all newly synthesized compounds were established on the basis of their FTIR, 1H NMR, 13C NMR, LC-MS as well as elemental analysis. All the newly design compounds were assayed for their in vitro antimicrobial activity against selected pathogens by the Broth dilution method and in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using Lowen...

Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to present the literature on 2-acetylbenzimidazole chemistry and provide valuable and up-to-date information for its applications. The present review is carried out by compiling literature from 1964 to 2020 concerning the synthesis and biological aspects of various heterocyclic compounds derived from 2-acetylbenzimidazole. Literature was collected from various online search engines viz. Google Scholar, PubMed, Science Direct, Core, and Semantic scholar. 2-acetylbenzimidazole has been successfully employed as a synthon to obtain heterocyclic system viz. oxirane, pyrazoline, thiazole, pyrazole, isoxazoline, isoxazole, pyridine, pyrimidine, thiazine, diazepine, and other miscellaneous rings. 2-acetylbenzimidazole has shown promise for the convenient synthesis of various heterocyclic compounds. The reactions can be carried out on various reactive sites of 2-acetylbenzimidazole, which are the carbonyl group and the amino group. This review will help to explore various heterocyclic compounds and particularly in the synthesis of biologically useful compounds.

Herein, a rapid and highly efficient method for the synthesis of a new series of pyrimidine derivatives was demonstrated. The strategy was emanated from the reaction of hydrazinyl pyrimidine derivative (1) with different electrophilic species such as ethyl acetoacetate, ethyl 4,4,4-trifluoro acetoacetate, and phe-nyl isothiocyanate following cyclocondensation mechanism to afford the corresponding derivatives (2-6). Furthermore, condensation of hydrazine derivative (1) with different carbonyl compounds via conventional heating and microwave irradiation conditions was employed as a source of Schiff base derivatives bearing pyrimidine moiety (7-12). The structural features of all newly synthesized compounds were characterized by elemental and spectro-scopic evidences. Some of the synthesized compounds were evaluated for in vitro cytotoxicity. The preliminary screening results showed that most of the tested compounds have moderate cytotoxic activity against HepG2 and HCT-116 cell lines. Finally, a molecular docking study was conducted to reveal the probable interaction with the thymidylate synthase enzyme.

In an attempt to find a new class of antimicrobial and antitubercular agent, a new series of chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5-triazine nucleus were synthesized with appropriate chemical reagent. Chalcones (D 1-D 5) were synthesized by the classical Claisen-Schmidt condensation of substituted ketone (C) with variously substituted aldehydes via conventional method. Now treatment of chalcones with hydrazine hydrate/glacial acetic acid and guanidine hydrochloride/Alkali afforded the corresponding acetyl pyrazoline (E 1-E 5) and amino pyrimidine (F 1-F 5) derivatives respectively. The chemical structures of all newly synthesized compounds were established on the basis of their FTIR, 1 H NMR, 13 C NMR, LC-MS as well as elemental analysis. All the newly design compounds were assayed for their in vitro antimicrobial activity against selected pathogens by the Broth dilution method and in vitro antitubercular activity against Mycobacterium tuberculosis H 37 Rv using Lowenstein-Jensen MIC method. Most of the compounds showed appreciable antimicrobial activity against the all tested strains. Among the synthesized compounds D 1 , D 2 , D 3 , E 1 , E 3 , E 4 , F 3 and F 4 exhibited excellent antimicrobial activity and said to be the most proficient members of the series. Compound D 5 and F 5 exhibited promising antitubercular activity. Capsule Summary: 1,3,5-Triazine based some new chalcones, acetyl pyrazolines and aminopyrimidines were synthesized by conventional route which exerted good antimicrobial as well as antitubercular activity.

A chemical reinvestigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to the isolation of three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures of the new compounds (6, 7, 10) were elucidated by employing spectroscopic techniques (NMR, MS, CD, and IR) as well as enantioselective analyses of methyl branched side chain configurations. Application of the precursor-directed feeding approach led to the production and partial isolation of nine further pyrimidine analogues. The new compounds 6, 7, and 11 and three of the known compounds (2-4) were found to possess antimycobacterial and cytotoxic properties.

Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint. Chromosomally unstable cancer cells rely heavily on MPS1 to cope with the stress arising from abnormal numbers of chromosomes and centrosomes and are thus more sensitive to MPS1 inhibition than normal cells. We report the discovery and optimization of a series of new pyrido[3,4-d]pyrimidine based inhibitors via a structure-based hybridization approach from our previously reported inhibitor CCT251455 and a modestly potent screening hit. Compounds in this novel series display excellent potency and selectivity for MPS1, which translates into biomarker modulation in an in vivo human tumor xenograft model.

An integrated computational approach built on quantum mechanical (QM) methods, purposely tailored inter-and intra-molecular force fields and continuum solvent models combined with time-independent and time-dependent schemes to account for nuclear motion effects is applied to the spectroscopic investigation of pyrimidine in the gas phase as well as in aqueous and CCl 4 solutions. Accurate post-Hartree–Fock methodologies are employed to compute molecular structure, harmonic vibrational frequencies, energies and ...

An integrated computational approach built on quantum mechanical (QM) methods, purposely tailored inter-and intra-molecular force fields and continuum solvent models combined with time-independent and time-dependent schemes to account for nuclear motion effects is applied to the spectroscopic investigation of pyrimidine in the gas phase as well as in aqueous and CCl 4 solutions. Accurate post-Hartree–Fock methodologies are employed to compute molecular structure, harmonic vibrational frequencies, energies and ...

The comparative analysis of growth regulating activity of new synthetic low molecular weight heterocyclic compounds (LMWHC), derivatives of pyrimidine, and plant hormones auxins IAA (1H-Indol-3-ylacetic acid) and NAA (1-Naphthylacetic acid) on vegetative growth of tomato (Solanum lycopersicum L.) cultivar Fakel was conducted in the laboratory conditions. Our study showed that synthetic LMWHC, derivatives of pyrimidine used at the concentration 10-9M demonstrated high auxin-like regulating activity on growth of tomato seedlings during the 8 weeks. The morphometric parameters of shoots and roots on the 8th-week-old tomato seedlings grown in perlite moistened with solutions of synthetic LMWHC, derivatives o f pyrimidine used at the concentration 10-9M were similar or higher to the morphometric parameters of shoots and roots on the 8th-week-old tomato seedlings grown in perlite moistened with distilled water (control) or solutions of plant hormones auxins IAA and NAA used at the same concentration 10-9M on average: to 21 - 30 % - for length of the shoots, to 8 - 80 % - for average shoot mass, to 10 - 20 % - for length of the main root, to 10 – 46 % - for average root mass, respectively. It was found that the plant growth regulating activity of these compounds depended on different substituents in the chemical structure of heterocyclic compounds. The obtained results proved the possibility of practical application of synthetic LMWHC, derivatives of pyrimidine as new effective regulators for vegetative growth of tomato (Solanum lycopersicum L.) cultivar Fakel.
Key words: tomato (Solanum lycopersicum L.), plant growth regulators, synthetic low molecular weight heterocyclic compounds, derivatives of pyrimidine, auxins IAA and NAA.