Further Assessment of Monkeypox Virus Infection in Gambian Pouched Rats (Cricetomys gambianus) Using In Vivo Bioluminescent Imaging
Fig 5
Luminescence is present in the absence of gross lesions of monkeypox disease.
In this photograph (left) of the right lateral leg of GPR1, 14 days after it was infected with Monkeypox virus that expresses luciferase, no skin lesions are apparent. However, on the right, the luminescent image of the same animal, on the same day, shows abundant viral replication in the leg and foot of this animal. This is clear evidence that viral replication can occur in the absence of visible skin lesions.