Schistosomes require aquatic snails as an intermediate host. In this work from Blouin et al, results from genome-wide mapping of the Biomphalaria glabrata host genome add to a growing body of work that suggests TM1 genes may play an important role in snail-schistosome compatibility polymorphisms. Identifying the interacting molecules on the schistosome side, and how they interact with snail proteins, might reveal ways we could genetically modify snails to make them unable to transmit schistosomes to humans.
Image Credit: Blouin et al, 2024
Viewpoints
Hope amidst neglect: Mycetoma Research Center, University of Khartoum. A holistic management approach to achieve the United Nations’ Sustainable Development Goals
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012420
Development and deployment of a solid oral amphotericin B dosage form to treat visceral leishmaniasis within a pediatric population
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012500
Policy Platform
From neglect to equity in snakebite envenoming; what the ICMR-Collaborative Centre of Excellence (CCoE) targets
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012425
All that glitters is not gold: An interpretive framework for diagnostic test evaluation using Ascaris lumbricoides as a conceptual example
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012481
Research Articles
Impact of vaccination against Japanese encephalitis in endemic countries
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012390
A novel antigen biomarker for detection of high-level of Loa loa microfilaremia
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012461
Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012452
Genomic analysis of Strongyloides stercoralis and Strongyloides fuelleborni in Bangladesh
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012440
Changing seroprevalence of schistosomiasis japonica in China from 1982 to 2020: A systematic review and spatial analysis
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012466
The impact of modified incision height and surgical procedure on trichiasis surgery outcomes: Results of the maximizing trichiasis surgery success (MTSS) randomized trial
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012034
Analysis of Cholera Risk in India: Insights from 2017–18 Serosurvey Data Integrated with Epidemiologic data and Societal Determinants from 2015–2019
PLOS Neglected Tropical Diseases: published September 3, 2024 | https://doi.org/10.1371/journal.pntd.0012450
AcuM and AcuK: The global regulators controlling multiple cellular metabolisms in a dimorphic fungus Talaromyces marneffei
PLOS Neglected Tropical Diseases: published September 4, 2024 | https://doi.org/10.1371/journal.pntd.0012145
Antibodies against medically relevant arthropod-borne viruses in the ubiquitous African rodent Mastomys natalensis
PLOS Neglected Tropical Diseases: published September 4, 2024 | https://doi.org/10.1371/journal.pntd.0012233
Comparative analysis of the microbiota of sand fly vectors of Leishmania major and L. tropica in a mixed focus of cutaneous leishmaniasis in southeast Tunisia; ecotype shapes the bacterial community structure
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012458
Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012477
Isolation and characterization of genetic variants of Orthohantavirus hantanense from clinical cases of HFRS in Jiangxi Province, China
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012439
Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012407
Diagnosis of brucellosis: Combining tests to improve performance
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012442
Linked-evidence modelling of qualitative G6PD testing to inform low- and intermediate-dose primaquine treatment for radical cure of Plasmodium vivax
PLOS Neglected Tropical Diseases: published September 5, 2024 | https://doi.org/10.1371/journal.pntd.0012486
Neglected tropical disease meets neglected community: Street children’s susceptibility to scabies in Addis Ababa, Ethiopia
PLOS Neglected Tropical Diseases: published September 6, 2024 | https://doi.org/10.1371/journal.pntd.0012475
Soil surveillance for monitoring soil-transmitted helminths: Method development and field testing in three countries
PLOS Neglected Tropical Diseases: published September 6, 2024 | https://doi.org/10.1371/journal.pntd.0012416
Prevalence of onchocerciasis and epilepsy in a Tanzanian region after a prolonged community-directed treatment with ivermectin
PLOS Neglected Tropical Diseases: published September 6, 2024 | https://doi.org/10.1371/journal.pntd.0012470
Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review
PLOS Neglected Tropical Diseases: published September 9, 2024 | https://doi.org/10.1371/journal.pntd.0012456
Increased levels of anti-Encephalitozoon intestinalis antibodies in patients with colorectal cancer
PLOS Neglected Tropical Diseases: published September 9, 2024 | https://doi.org/10.1371/journal.pntd.0012459
Prevalence of human schistosomiasis in various regions of Tanzania Mainland and Zanzibar: A systematic review and meta-analysis of studies conducted for the past ten years (2013–2023)
PLOS Neglected Tropical Diseases: published September 9, 2024 | https://doi.org/10.1371/journal.pntd.0012462
Development of new real-time PCR assays for detection and species differentiation of Plasmodium ovale
PLOS Neglected Tropical Diseases: published September 10, 2024 | https://doi.org/10.1371/journal.pntd.0011759
Abundance and Leishmania infection patterns of the sand fly Psathyromyia cratifer in Southern Mexico
PLOS Neglected Tropical Diseases: published September 10, 2024 | https://doi.org/10.1371/journal.pntd.0012426
Larval crowding enhances dengue virus loads in Aedes aegypti, a relationship that might increase transmission in urban environments
PLOS Neglected Tropical Diseases: published September 10, 2024 | https://doi.org/10.1371/journal.pntd.0012482
A regional One Health approach to the risk of invasion by Anopheles stephensi in Mauritius
PLOS Neglected Tropical Diseases: published September 11, 2024 | https://doi.org/10.1371/journal.pntd.0011827
Self-healing in leprosy: A systematic review
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012434
The discovery of novel variants reveals the genetic diversity and potential origin of Seoul orthohantavirus
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012478
Wolbachia and mosquitoes: Exploring transmission modes and coevolutionary dynamics in Shandong Province, China
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0011944
Computer-aided discovery of novel SmDHODH inhibitors for schistosomiasis therapy: Ligand-based drug design, molecular docking, molecular dynamic simulations, drug-likeness, and ADMET studies
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012453
Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012502
Effects of the El Niño-Southern Oscillation and seasonal weather conditions on Aedes aegypti infestation in the State of São Paulo (Brazil): A Bayesian spatio-temporal study
PLOS Neglected Tropical Diseases: published September 12, 2024 | https://doi.org/10.1371/journal.pntd.0012397
Exposure patterns and the risk factors of Crimean Congo hemorrhagic fever virus amongst humans, livestock and selected wild animals at the human/livestock/wildlife interface in Isiolo County, upper eastern Kenya
PLOS Neglected Tropical Diseases: published September 13, 2024 | https://doi.org/10.1371/journal.pntd.0012083
Repelling Aedes aegypti mosquitoes with electric fields using insulated conductor wires
PLOS Neglected Tropical Diseases: published September 13, 2024 | https://doi.org/10.1371/journal.pntd.0012493
Dissimilar Trypanosoma cruzi genotype-specific serological profile assessed by Chagas-Flow ATE IgG1 upon benznidazole etiological treatment of chronic Chagas disease
PLOS Neglected Tropical Diseases: published September 13, 2024 | https://doi.org/10.1371/journal.pntd.0012487
Improving health behaviours and attitudes around podoconiosis in Northern Western Ethiopia: Implementation and intervention effectiveness
PLOS Neglected Tropical Diseases: published September 16, 2024 | https://doi.org/10.1371/journal.pntd.0012507
Temperature dependence of mosquitoes: Comparing mechanistic and machine learning approaches
PLOS Neglected Tropical Diseases: published September 16, 2024 | https://doi.org/10.1371/journal.pntd.0012488
Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins
PLOS Neglected Tropical Diseases: published September 16, 2024 | https://doi.org/10.1371/journal.pntd.0012474
Challenges in rescuing snakes to protect human lives and promote snake conservation in Tamil Nadu, India
PLOS Neglected Tropical Diseases: published September 17, 2024 | https://doi.org/10.1371/journal.pntd.0012516
Oral Chagas disease outbreak by bacaba juice ingestion: A century after Carlos Chagas’ discovery, the disease is still hard to manage
PLOS Neglected Tropical Diseases: published September 18, 2024 | https://doi.org/10.1371/journal.pntd.0012225
Comparative evaluation of plasma biomarkers of Schistosoma haematobium infection in endemic populations from Burkina Faso
PLOS Neglected Tropical Diseases: published September 18, 2024 | https://doi.org/10.1371/journal.pntd.0012104
Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda
PLOS Neglected Tropical Diseases: published September 19, 2024 | https://doi.org/10.1371/journal.pntd.0012451
Clinical presentation of human leptospirosis in febrile patients: Urabá, Colombia
PLOS Neglected Tropical Diseases: published September 19, 2024 | https://doi.org/10.1371/journal.pntd.0012449
Spatio-temporal patterns of dengue in Bangladesh during 2019 to 2023: Implications for targeted control strategies
PLOS Neglected Tropical Diseases: published September 20, 2024 | https://doi.org/10.1371/journal.pntd.0012503
Communities’ knowledge, perceptions and preventive practices on soil-transmitted helminthes in Jimma, Oromia, Ethiopia: Formative mixed study
PLOS Neglected Tropical Diseases: published September 20, 2024 | https://doi.org/10.1371/journal.pntd.0012483
Revisiting the impact of Schistosoma mansoni regulating mechanisms on transmission dynamics using SchiSTOP, a novel modelling framework
PLOS Neglected Tropical Diseases: published September 20, 2024 | https://doi.org/10.1371/journal.pntd.0012464
Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012514
Breaking the silence of female genital schistosomiasis in Ghana’s health system: A case of health workers within the FAST project
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012443
Human Ascaris infection is associated with higher frequencies of IL-10 producing B cells
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012520
Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012155
Performance characteristics of STANDARD Q Filariasis Antigen test (QFAT) to detect filarial antigens of Wuchereria bancrofti in the field
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012538
Unveiling viral pathogens in acute respiratory disease: Insights from viral metagenomics in patients from the State of Alagoas, Brazil
PLOS Neglected Tropical Diseases: published September 23, 2024 | https://doi.org/10.1371/journal.pntd.0012536
Persistent transmission of soil-transmitted helminths despite 16 years of uninterrupted Mebendazole- and ivermectin-based preventive chemotherapy in the Lomie Health District (East Region, Cameroon): The emergency of complementary control strategies
PLOS Neglected Tropical Diseases: published September 25, 2024 | https://doi.org/10.1371/journal.pntd.0012508
Sand flies and Toscana virus: Intra-vector infection dynamics and impact on Phlebotomus perniciosus life-history traits
PLOS Neglected Tropical Diseases: published September 25, 2024 | https://doi.org/10.1371/journal.pntd.0012509
Urogenital schistosomiasis in schoolchildren in the lake zones of Kankossa and Oued Rawdha, southern Mauritania: The first parasitological and malacological survey
PLOS Neglected Tropical Diseases: published September 25, 2024 | https://doi.org/10.1371/journal.pntd.0012505
ST8Sia2 polysialyltransferase protects against infection by Trypanosoma cruzi
PLOS Neglected Tropical Diseases: published September 25, 2024 | https://doi.org/10.1371/journal.pntd.0012454
Impacts of climate change on diarrhoeal disease hospitalisations: How does the global warming targets of 1.5–2°C affect Dhaka, Bangladesh?
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012139
Infection patterns of scabies and tinea between inland and resettled indigenous Negrito communities in Peninsular Malaysia
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012515
Reassessing the distribution of Burkholderia pseudomallei outside known endemic areas using animal serological screening combined with environmental surveys: The case of Les Saintes (Guadeloupe) and French Guiana
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0011977
Updated annotation and meta-analysis of Brugia malayi transcriptomics data reveals consistent transcriptional profiles across time and space with some study-specific differences in adult female worm transcriptional profiles
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012511
Ecological study measuring the association between conflict, environmental factors, and annual global cutaneous and mucocutaneous leishmaniasis incidence (2005–2022)
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012549
Stable introduction of Wolbachia wPip into invasive Anopheles stephensi for potential malaria control
PLOS Neglected Tropical Diseases: published September 26, 2024 | https://doi.org/10.1371/journal.pntd.0012523
Epidemiology of human and animal leptospirosis in Kenya: A systematic review and meta-analysis of disease occurrence, serogroup diversity and risk factors
PLOS Neglected Tropical Diseases: published September 27, 2024 | https://doi.org/10.1371/journal.pntd.0012527
Environmental surveillance for Salmonella Typhi in rivers and wastewater from an informal sewage network in Blantyre, Malawi
PLOS Neglected Tropical Diseases: published September 27, 2024 | https://doi.org/10.1371/journal.pntd.0012518
Molecular evidence of pathogens and endosymbionts in the black horse fly Osca lata (Diptera: Tabanidae) in Southern Chile
PLOS Neglected Tropical Diseases: published September 27, 2024 | https://doi.org/10.1371/journal.pntd.0012525
Artificial intelligence-based digital pathology for the detection and quantification of soil-transmitted helminths eggs
PLOS Neglected Tropical Diseases: published September 30, 2024 | https://doi.org/10.1371/journal.pntd.0012492
A preliminary indication that HLA-A*03:01 may be associated with visceral leishmaniasis development in people living with HIV in Ethiopia
PLOS Neglected Tropical Diseases: published September 30, 2024 | https://doi.org/10.1371/journal.pntd.0012000
Molecular detection of Rickettsia species in ectoparasites collected from two southern provinces of Cambodia
PLOS Neglected Tropical Diseases: published September 30, 2024 | https://doi.org/10.1371/journal.pntd.0012544
HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA
PLOS Neglected Tropical Diseases: published September 30, 2024 | https://doi.org/10.1371/journal.pntd.0012553
In vivo screening of flavonoid compounds revealed quercetin as a potential drug to improve recovery of angiostrongyliasis after albendazole treatment
PLOS Neglected Tropical Diseases: published September 30, 2024 | https://doi.org/10.1371/journal.pntd.0012526
Corrections
Correction: Immunogenic Salivary Proteins of Triatoma infestans: Development of a Recombinant Antigen for the Detection of Low-Level Infestation of Triatomines
PLOS Neglected Tropical Diseases: published September 9, 2024 | https://doi.org/10.1371/journal.pntd.0012484
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PLOS Neglected Tropical Diseases: published September 11, 2024 | https://doi.org/10.1371/journal.pntd.0012480
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