09/06/2024
Short Reports
The brain is anatomically organized in columns, but how these columns relate to function in the human association cortex is not clear. Daniel Cleary, Youngbin Tchoe, Eric Halgren and co-workers reveal that the human superior temporal gyrus is functionally organized in ~1.7-mm diameter modules that process language information.
Image credit: pbio.3002774
Current Issue August 2024
09/06/2024
Research Article
Refeeding after a period of fasting induces a metabolic switch in the liver and can lead to a 'fat overshoot', where fat mass surpasses pre-fasting levels. Noga Korenfeld, Carolyn Cummins, Ido Goldstein and co-authors elucidate the kinetics of transcriptional and chromatin changes induced by refeeding, revealing a lipogenic overshoot program that is regulated by the transcription factor LXRα.
Image credit: pbio.3002735
09/05/2024
Short Reports
What are the effects of centrosome amplification in cancer? Frances Edwards, Renata Basto and colleagues show that extra centrosomes prime ovarian cancer cells for apoptosis, acting in synergy with chemotherapy to induce cell death. High centrosome numbers correlate with improved treatment responses and longer survival.
Image credit: pbio.3002759
09/04/2024
Short Reports
How do integrins and paxillin interact at focal adhesions? Timo Baade, Marcus Michaelis, Christof Hauck, Heiko Möller and co-authors present a 3D-structure of the LIM3 domain of paxillin, which reveals a direct association between paxillin and the cytoplasmic tail of the integrin beta subunit.
Image credit: pbio.3002757
09/03/2024
Research Article
53BP1 is a DNA damage repair factor that regulates gene expression for tumor suppression and neural development, but its precise regulatory mechanisms are unclear. Bitna Lim, Yurika Matsui, Jamy Peng and co-workers show that phosphorylation of 53BP1 by ATM kinase is crucial for modulating genetic programs in neural progenitors and cortical organoids.
Image credit: pbio.3002760
09/03/2024
Research Article
Vibrio coralliilyticus is a pathogen of coral and shellfish that is becoming more virulent as ocean temperatures rise. Shir Mass, Dor Salomon and colleagues show that V. coralliilyticus has two type VI secretion systems (T6SSs) that are activated at high temperatures; one targets bacterial competitors, while the other launches up to 9 novel toxins against eukaryotic hosts like shrimps. See also the accompanying Primer.
Image credit: pbio.3002734
09/05/2024
Perspective
Florencia Assaneo, Fernando Lizcano-Cortés and Pablo Ripolles discusses a new hypothesis that may help to resolve the debate by explaining how training in rhythmic skills might improve cognitive abilities in some individuals, but not others.
Image credit: Wikimedia Commons Brandon Giesbrecht
08/29/2024
Unsolved Mystery
Manuel Ares-Arroyo, Charles Coluzzi, Jorge Moura de Sousa and Eduardo Rocha explore how microbial evolution is shaped by mobile genetic elements regulating each other. These functional dependencies raise numerous questions.
Image credit: pbio.3002796
08/29/2024
Essay
Following Niko Tinbergen’s roadmap for behavioral investigation, Reut Vardi, Valerio Sbragaglia and colleagues show how using videos, photos, text, and audio posted online can shed new light on known behaviors and lead to the discovery of new ones.
Image credit: pbio.3002793
08/26/2024
Community Page
James Canham, Joe Win, Sophien Kamoun and colleagues introduce GetGenome, a non-profit organization that aims to provide global and affordable access to genomics technology and training.
Image credit: pbio.3002804
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.
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