02/13/2025
Research Article
Deepanshu Singh, Alicia Hidalgo and colleagues identify a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering neurodegeneration.
Image credit: pbio.3003020
Current Issue January 2025
02/13/2025
Research Article
Tropical forests hold most of Earth’s biodiversity and a higher concentration of threatened mammals than other biomes. Ilaria Greco, Francesco Rovero and co-authors use a standardized pan-tropical dataset of 239 mammal species from 37 forests across 3 continents to provide evidence of selective extinction occurring within tropical forests triggered by anthropogenic pressure in the broader landscape.
Image credit: pbio.3002976
02/11/2025
Research Article
How does the hippocampus support value-based decisions under motivational conflict? Through a mix of computational modelling approaches and behavioral studies in people with hippocampal damage, Willem Le Duc, Andy Lee and co-workers show that the hippocampus is critical for the evidence accumulation processes that support approach-avoidance conflict decision-making.
Image credit: pbio.3003033
02/11/2025
Research Article
How does repetitive stress impact sensory processing and perception? Ghattas Bisharat, Jennifer Resnik and colleagues reveal a pathway through which repetitive stress modifies basic sensory processing and perception in mice, showing how repetitive stress alters sound processing through progressive changes that intensify with continued exposure.
Image credit: Edvard Munch via Wikimedia Commons
02/06/2025
Research Article
Dysregulation of RNA stability is linked to neurodevelopmental disorders, but how it contributes to cortical development is not well understood. Lucas Serdar, Debra Silver and co-workers profile the RNA stability landscape of the cortex across development and reveal that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo.
Image credit: pbio.3003031
02/06/2025
Research Article
Iron-sulfur proteins require specialized assembly pathways and play vital roles in cellular functions. Eléa Renaud, Sébastien Besteiro and co-authors show that the plastid-derived protein HCF101 functions in the cytosolic Fe-S assembly pathway in Toxoplasma gondii, where it is crucial for Fe-S protein assembly and parasite viability.
Image credit: pbio.3003028
02/14/2025
Community Page
GitHub, widely used in software development, offers a robust framework for documenting laboratory research projects. This Community Page article explores how to incorporate the GitHub ecosystem into ‘wet’ lab workflows.
Image credit: pbio.3003029
02/07/2025
Perspective
Common altmetrics indices are limited and biased in the social media that they cover. Ivan Jarić, Pavel Pipek and Ana Novoa argue that altmetrics should broaden its scope to provide more reliable metrics for scientific content and communication.
Image credit: pbio.3003010
01/15/2025
Perspective
When models are used to inform decision-making, both their strengths and limitations must be considered. Using malaria as an example, Jaline Gerardin and Melissa Penny explain how and why models are limited and offer guidance for a model to fulfil its purpose.
Image credit: Wikimedia Commons Juan Carlos Fonseca Mata
01/15/2025
Perspective
‘‘Big data" from outsourced or centralized facilities often lacks methodological information. Daniel Sloan and Mark Stenglein outline how and why researchers, service providers, and other parties should report on methodology and sample metadata to improve scientific reproducibility.
Image credit: Wikimedia Commons Our World In Data
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
February 17 - 20
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
February 27 - March 1
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
March 4 - 7
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
March 12 - 14
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
March 12 - 16
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
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