KYAT1

KYAT1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1W7L, 1W7M, 1W7N, 3FVS, 3FVU, 3FVX, 4WLH, 4WLJ, 4WP0
Identifikatori
Aliasi	KYAT1
Vanjski ID-jevi	OMIM: 600547 MGI: 1917516 HomoloGene: 37872 GeneCards: KYAT1
EC broj	4.4.1.13
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	30,095,859 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • kynurenine-oxoglutarate transaminase activity; • protein homodimerization activity; • L-glutamine:pyruvate aminotransferase activity; • transaminase activity; • glutamine-phenylpyruvate transaminase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • catalytic activity; • lyase activity; • L-phenylalanine:pyruvate aminotransferase activity; • pyridoxal phosphate binding; • L-glutamine aminotransferase activity; • cysteine-S-conjugate beta-lyase activity;
Ćelijska komponenta	• nukleoplazma; • citoplazma; • citosol; • mitohondrija;
Biološki proces	• L-phenylalanine catabolic process; • cellular amino acid biosynthetic process; • Biosinteza; • L-kynurenine catabolic process; • tryptophan catabolic process; • cellular modified amino acid metabolic process; • kynurenine metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	883
	70266
	ENSG00000171097
	ENSMUSG00000039648
	Q16773
	Q8BTY1
	NM_001122671; NM_001122672; NM_001287390; NM_004059
	NM_172404; NM_001356474; NM_001356475
NP_001116143; NP_001116144; NP_001274319; NP_004050; NP_001339917;
	NP_001339918; NP_001339919; NP_001339920; NP_001339921; NP_001339922; NP_001339923; NP_001339924; NP_001339925; NP_001339926; NP_001339927; NP_001339928
	NP_765992; NP_001343403; NP_001343404
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kinureninska oksoglutarat-transaminaza 1 je enzim koji je kod ljudi kodiran genom CCBL1.^[4]^[5] To je jedna od kinurenin-oksoglutarat transaminaza.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 422 aminokiseline, а molekulska težina 47.875 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAKQLQARRL	DGIDYNPWVE	FVKLASEHDV	VNLGQGFPDF	PPPDFAVEAF
QHAVSGDFML	NQYTKTFGYP	PLTKILASFF	GELLGQEIDP	LRNVLVTVGG
YGALFTAFQA	LVDEGDEVII	IEPFFDCYEP	MTMMAGGRPV	FVSLKPGPIQ
NGELGSSSNW	QLDPMELAGK	FTSRTKALVL	NTPNNPLGKV	FSREELELVA
SLCQQHDVVC	ITDEVYQWMV	YDGHQHISIA	SLPGMWERTL	TIGSAGKTFS
ATGWKVGWVL	GPDHIMKHLR	TVHQNSVFHC	PTQSQAAVAE	SFEREQLLFR
QPSSYFVQFP	QAMQRCRDHM	IRSLQSVGLK	PIIPQGSYFL	ITDISDFKRK
MPDLPGAVDE	PYDRRFVKWM	IKNKGLVAIP	VSIFYSVPHQ	KHFDHYIRFC
FVKDEATLQA	MDEKLRKWKV	EL

Funkcija

Ovaj gen kodira citosolni enzim koji je odgovoran za metabolizam cisteinskih konjugata određenih halogeniranih alkena i alkana. Taj metabolizam dovodi do stvaranja reaktivnih metabolita koji mogu dovesti do nefrotoksičnosti i neurotoksičnosti.^[5]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039648 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P (Apr 1995). "Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase". FEBS Lett. 360 (3): 277–80. doi:10.1016/0014-5793(95)00123-Q. PMID 7883047. S2CID 83606450.
^ ^a ^b "Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)".
^ "UniProt, Q16773". Pristupljeno 9. 9. 2021.

Dopunska literatura

Cooper AJ (2004). "The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants". Neurochem. Int. 44 (8): 557–77. doi:10.1016/j.neuint.2003.12.002. PMID 15016471. S2CID 7643547.
Lash LH, Nelson RM, Van Dyke RA, Anders MW (1990). "Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity". Drug Metab. Dispos. 18 (1): 50–4. PMID 2139845.
Abraham DG, Patel PP, Cooper AJ (1995). "Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4". J. Biol. Chem. 270 (1): 180–8. doi:10.1074/jbc.270.1.180. PMID 7814371.
Goldfarb P, Perry S, Harries H, et al. (1996). "Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase". Biochem. Soc. Trans. 24 (2): 330S. doi:10.1042/bst024330s. PMID 8736988.
Iyer RA, Anders MW (1997). "Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria". Anesthesiology. 85 (6): 1454–61. doi:10.1097/00000542-199612000-00028. PMID 8968194. S2CID 39394531.
Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Hum. Mol. Genet. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kapoor R, Lim KS, Cheng A, et al. (2006). "Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1)". Brain Res. 1106 (1): 205–10. doi:10.1016/j.brainres.2006.05.082. PMID 16828464. S2CID 42325649.

Vanjski linkovi

Lokacija ljudskog genoma CCBL1 i stranica sa detaljima o genu CCBL1 u UCSC Genome Browseru.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000039648 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7883047-4] Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P (Apr 1995). "Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase". FEBS Lett. 360 (3): 277–80. doi:10.1016/0014-5793(95)00123-Q. PMID 7883047. S2CID 83606450.

[entrez-5] "Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)".

[UniProt-6] "UniProt, Q16773". Pristupljeno 9. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak