ENTPD3
Ektonukleozid-trifosfat difosfohidrolaza 3 jest enzim koji je kod ljudi kodiran genom ENTPD3 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 529 aminokiselina, а molekulska težina 59.105 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MFTVLTRQPC | EQAGLKALYR | TPTIIALVVL | LVSIVVLVSI | TVIQIHKQEV | ||||
| LPPGLKYGIV | LDAGSSRTTV | YVYQWPAEKE | NNTGVVSQTF | KCSVKGSGIS | ||||
| SYGNNPQDVP | RAFEECMQKV | KGQVPSHLHG | STPIHLGATA | GMRLLRLQNE | ||||
| TAANEVLESI | QSYFKSQPFD | FRGAQIISGQ | EEGVYGWITA | NYLMGNFLEK | ||||
| NLWHMWVHPH | GVETTGALDL | GGASTQISFV | AGEKMDLNTS | DIMQVSLYGY | ||||
| VYTLYTHSFQ | CYGRNEAEKK | FLAMLLQNSP | TKNHLTNPCY | PRDYSISFTM | ||||
| GHVFDSLCTV | DQRPESYNPN | DVITFEGTGD | PSLCKEKVAS | IFDFKACHDQ | ||||
| ETCSFDGVYQ | PKIKGPFVAF | AGFYYTASAL | NLSGSFSLDT | FNSSTWNFCS | ||||
| QNWSQLPLLL | PKFDEVYARS | YCFSANYIYH | LFVNGYKFTE | ETWPQIHFEK | ||||
| EVGNSSIAWS | LGYMLSLTNQ | IPAESPLIRL | PIEPPVFVGT | LAFFTAAALL | ||||
| CLAFLAYLCS | ATRRKRHSEH | AFDHAVDSD |
Funkcija
[uredi | uredi izvor]ENTPD3 je sličan nukleotidazama E-tipa (NTPaza). NTPaze, kao što je CD39, posreduju katabolizam vanćelijskih nukleotida. ENTPD3 sadrži četiri apirazno konzervirane regije, što je karakteristično za NTPaze.[6]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
- ^ a b "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".
- ^ "UniProt, O75355" (jezik: engleski). Pristupljeno 3. 11. 2021.
Dopunska literatura
[uredi | uredi izvor]- Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists". Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
- Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling". Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions". Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
- Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase". Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
- Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1". Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
- Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.