- Celal Bayar, Cumhuriyet, Sivas, Manisa, Turkey
Tevfik Guvenal
Celal Bayar University, Obstetrics and Gynecology, Faculty Member
It was previously shown that sustained fever can be induced in rats by central injection of endothelin-1 (ET-1). This peptide appears to participate in the mechanism(s) of LPS-induced fever, which is reduced by pretreatments with ETB... more
It was previously shown that sustained fever can be induced in rats by central injection of endothelin-1 (ET-1). This peptide appears to participate in the mechanism(s) of LPS-induced fever, which is reduced by pretreatments with ETB receptor antagonists. In this study, we compared the effects of a nonselective cyclooxygenase (COX) inhibitor, indomethacin, with those of two selective COX-2 inhibitors, celecoxib and lumiracoxib, on ET-1-induced fever in rats. Fever induced in conscious animals by ET-1 (1 pmol icv) or LPS (5 μg/kg iv) was prevented by pretreatments with celecoxib (5 and 10 mg/kg) or lumiracoxib (5 mg/kg) given by oral gavage 1 h before stimuli. Lower doses of celecoxib had partial (2.5 mg/kg) or no effect (1 mg/kg). Indomethacin (2 mg/kg ip) partially inhibited fever induced by LPS but had no effect on ET-1-induced fever. The levels of PGE2 and PGF2α in the cerebrospinal fluid (CSF) of pentobarbital sodium-anesthetized rats were significantly increased 3 h after the i...
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Copyright © 2013 Pinar Solmaz Hasdemir et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original... more
Copyright © 2013 Pinar Solmaz Hasdemir et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Intermittent pelvic pain caused by ovarian cysts in adolescencemay be due to torsion or partial torsion of the ovary.Wepresent a case of 18-year old adolescent with symptomatic left ovarian torsionwith calcifications demonstrated by pelvicMRI and ultrasonography prior to surgery. The pathologic investigation demonstrated dystrophic calcifications. We speculated that the pattern of the intermittent pain in the story of the patient and the dystrophic calcifications in pathologic investigation which is thought that it might have been potentially developed as a result of chronic hypoxia due to intermittent partial torsions over a period of two years. 1.
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OBJECTIVE: To evaluate maternal and fetal outcome in pregnancies of women aged 35 and more. STUDY DESIGN: In this retrospective analysis of advanced maternal age pregnancies a total of 237 patient records were evaluated. Age, gestational... more
OBJECTIVE: To evaluate maternal and fetal outcome in pregnancies of women aged 35 and more. STUDY DESIGN: In this retrospective analysis of advanced maternal age pregnancies a total of 237 patient records were evaluated. Age, gestational age, birth weights, Apgar scores, maternal hemoglobin, hematocrit, preeclampsia, cesarean section, gestational diabetes, intrauterine fetal demise and fetal anomalies were compared between young and older women. RESULTS: There was a higher rate of preeclampsia, gestational diabetes and intrauterine fetal demise in the older age group. Higher 5th minute Apgar scores, higher hematocrit values and higher cesarean section rates were observed in the control age group. There was no difference in terms of birth weight, prematurity, low birth weight, meconium aspiration or fetal anomaly. CONCLUSION: Advanced maternal age is a risk factor for preeclampsia and gestational diabetes even in healthy women. Meticulous antenatal care should be offered to older pre...
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Vulvanin primer adenokarsinomu oldukca nadir gorulen bir kanserdir. Altmis yedi yasinda sag vulvada kanamali kitle ve agri nedeni ile basvuran olgunun sag vulvadan baslayan perineal kismi ve sag vajen yan duvarini icine alan ekzofitik... more
Vulvanin primer adenokarsinomu oldukca nadir gorulen bir kanserdir. Altmis yedi yasinda sag vulvada kanamali kitle ve agri nedeni ile basvuran olgunun sag vulvadan baslayan perineal kismi ve sag vajen yan duvarini icine alan ekzofitik kanamali lezyon ile sag ingiunal lenf adenopatisi mevcuttu. Vulva biopsisinde adenokarsinom olarak saptandi. Klinik muayene ve degerlendirmeler sonucu primer serviks, endometrium ve rektumda patoloji saptanmadi. Olguya genis lokal ekzisyon uygulandi. Ayni tarafa ingiunal lenf diseksiyonu ve retroperitoneal lenf diseksiyonu yapildi. Patoloji sonucu vulvanin primer adenokarsinom oldugu saptandi. Postoperatif radyoterapi alamayan olguda 2 yil sonra lenfadenektomi uygulanan bolgede rekurrens ile uyumlu kitle gelisti. Kitle eksize edien olguya daha sonra radyoterapi uygulandi. Hasta operasyondan 7 yil sonra hastaliksiz bir durumda bulunmaktadir.
Amac: Gestasyonel trofoblastik hastalik (GTH) tanisi almis olgularin klinikopatolojik ozelliklerinin ve tedavilerinin degerlendirilmesi. Yontemler: 2003- 2013 yillari arasinda klinigimize GTH tanisi ile yatirilmis olan ve bilgilerine... more
Amac: Gestasyonel trofoblastik hastalik (GTH) tanisi almis olgularin klinikopatolojik ozelliklerinin ve tedavilerinin degerlendirilmesi. Yontemler: 2003- 2013 yillari arasinda klinigimize GTH tanisi ile yatirilmis olan ve bilgilerine ulasilan 34 hasta bu calismaya alinmistir. Hastalarin demografik, kliniko-patolojik ozellikleri ile uygulanan tedavi yontemleri ve izlem sonuclari retrospektif olarak degerlendirilmistir. Bulgular: Calismamizda 27 adet hidatiform mol (HM) (15 komplet, 12 parsiyel), 7 adet non-metastatik gestasyonel trofoblastik neoplazi (NM-GTN) olgusu degerlendirilmistir. Olgularin yas ortalamasi 31,3± 9,2 yil, ortalama gebelik sayisi 2,7± 1,5, ortalama dogum sayisi 1,13± 1,03, dusuk ve gecirilmis mol gebelik oranlari sirasiyla ortalama 0,3± 0,5 ve 0,1± 0,4 seklinde idi. HM tanisi almis olgularin 3 tanesinde (%8,8) tedavi sonrasi mol gebelik tekrarlamis, bunlardan birinde histerektomi, diger ikisinde tekrar revuzyone kuretaj (R/C) ile remisyon saglanmistir. NM-GTN tani...
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hafif, şiddetli preeklampsi ve eklampsi klinik tablolarına sahip obstetrik bir hastalıktır. Temel bulguları hipertansiyon, ödem ve proteinüri olarak bilinmekle birlikte sistemik patolojik ve fizyopatolojik değişiklikler oluşturmaktadır.... more
hafif, şiddetli preeklampsi ve eklampsi klinik tablolarına sahip obstetrik bir hastalıktır. Temel bulguları hipertansiyon, ödem ve proteinüri olarak bilinmekle birlikte sistemik patolojik ve fizyopatolojik değişiklikler oluşturmaktadır. Bu önemli değişikliklerin bir kısmı plazma faktörleri, regülatör proteinler ve trombositler yoluyla hemostatik sistemde görülür. Preeklampside hemoliz, yüksek karaciğer enzimleri ve trombositopeni diğer bulgulardan daha belirginse HELLP sendromu olarak isimlendirilmektedir (1). Preeklamptik gebeliklerde bu Preeklampsi ve HELLP (Hemoliz, Yüksek Karaciğer Enzimleri ve Trombositopeni) Sendromu Olan Gebelerde Trombositopeninin Kanama Zamanına Etkisi
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Research Interests: Medicine and Cumhuriyet
Endometrium kanseri, gelişmiş ülkelerde en sık görülen kadın genital sistem kanseridir. Olguların büyük çoğunluğu erken evrede bulunmakta ve tümörün yaygınlığı abdominal yol ile yapılan cerrahi evreleme ile değerlendirilmektedir. Vajinal... more
Endometrium kanseri, gelişmiş ülkelerde en sık görülen kadın genital sistem kanseridir. Olguların büyük çoğunluğu erken evrede bulunmakta ve tümörün yaygınlığı abdominal yol ile yapılan cerrahi evreleme ile değerlendirilmektedir. Vajinal histerektomi ve bilateral salpingooferektomi ...
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Research Interests: Endocrinology, Genetics, Cardiology, Hematology, Nephrology, and 15 moreNeurology, Epidemiology, Immunology, Dexamethasone, Allergy, Liver, Mice, Female, Animals, Male, Lung, Body Weight, Fetus, Glucocorticoids, and Betamethasone
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The aim of this study was to compare in vivo effects of single and repetitive doses of betamethasone (BETA) and dexamethasone (DEX) administered to pregnant mice on lung maturation and lung, liver, and body weights (LLBW) of their pups.... more
The aim of this study was to compare in vivo effects of single and repetitive doses of betamethasone (BETA) and dexamethasone (DEX) administered to pregnant mice on lung maturation and lung, liver, and body weights (LLBW) of their pups. One hundred and ...
Research Interests: Endocrinology, Genetics, Cardiology, Hematology, Nephrology, and 15 moreNeurology, Epidemiology, Immunology, Dexamethasone, Allergy, Liver, Mice, Female, Animals, Male, Lung, Body Weight, Fetus, Glucocorticoids, and Betamethasone
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Research Interests: Immunohistochemistry, Medicine, Adhesion, Fertility and Sterility, Female, and 14 moreAnimals, Clinical Sciences, Rats, Public health systems and services research, Time Factors, Gonadotropin Releasing Hormone, Wistar Rats, Rat Model, Uterus, Leuprolide, Postoperative Complications, Severity of Illness Index, Uterine diseases, and Paediatrics and reproductive medicine
Research Interests: Immunohistochemistry, Medicine, Adhesion, Fertility and Sterility, Female, and 14 moreAnimals, Clinical Sciences, Rats, Public health systems and services research, Time Factors, Gonadotropin Releasing Hormone, Wistar Rats, Rat Model, Uterus, Leuprolide, Postoperative Complications, Severity of Illness Index, Uterine diseases, and Paediatrics and reproductive medicine
Results: The patients were similar in age, parity, menopausal status, grade of cystocel and preoperative residual urine volumes. Fourteen out of 20 (70%) patients showed improvement in the group undergoing Burch colposuspension, 29 out of... more
Results: The patients were similar in age, parity, menopausal status, grade of cystocel and preoperative residual urine volumes. Fourteen out of 20 (70%) patients showed improvement in the group undergoing Burch colposuspension, 29 out of 39 (74.4%) patients showed improvement ...
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Research Interests: Medicine and Cumhuriyet
To investigate the role of cytoreductive surgery in patients with nongenital cancers metastatic to the ovaries.One hundred and fifty-four patients with nongenital cancers metastatic to the ovaries treated in Hacettepe University Hospital,... more
To investigate the role of cytoreductive surgery in patients with nongenital cancers metastatic to the ovaries.One hundred and fifty-four patients with nongenital cancers metastatic to the ovaries treated in Hacettepe University Hospital, Gynecologic Oncology Unit between 1982 and 2004 years were retrospectively evaluated. Data were obtained from patients' records and pathology reports. Demographic characteristics, prognostic factors, 5-year and median survivals were analyzed in all patients.During study period, nongenital cancers metastatic to the ovaries constituted 9% of all malignant ovarian neoplasms. Primary cancers were breast (35), stomach (35) and colorectal (33) cancers, lymphoma (17), undetermined origin (16), appendix (7), ileum (4), pancreas (3), gallbladder cancer (2) and mesothelioma (2). Of patients, 67% were premenopausal and 33% were postmenopausal. Although most common presenting symptoms were abdominal distension with dyspeptic complaints in 46%, abdominal m...
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Anatolian Journal of Obstetrics & Gynecology ISSN: 1308-8254 Anatol J Obstet Gynecol 2010; 1: 2 ©2009 Goker Tamay et al.; licensee ALKIM BASIN YAYIN Ltd. ... Idiopathic labial fusion in a young adult: a case report ... Asli GOKER TAMAY,... more
Anatolian Journal of Obstetrics & Gynecology ISSN: 1308-8254 Anatol J Obstet Gynecol 2010; 1: 2 ©2009 Goker Tamay et al.; licensee ALKIM BASIN YAYIN Ltd. ... Idiopathic labial fusion in a young adult: a case report ... Asli GOKER TAMAY, Mehmet ADIYEKE, ...
To determine whether vaginal hysterectomy can be performed in patients with benign gynecologic diseases regardless of uterine size, uterine mobility and previous pelvic surgery and to compare with abdominal hysterectomy. Between 2003 and... more
To determine whether vaginal hysterectomy can be performed in patients with benign gynecologic diseases regardless of uterine size, uterine mobility and previous pelvic surgery and to compare with abdominal hysterectomy. Between 2003 and 2008, we compared 47 vaginal hysterectomies (VH) with 61 abdominal hysterectomies (AH). We excluded from the study the clinical conditions that mandate abdominal exploration and standard indications for VH such as uterovaginal prolapse. Large, immobile uterus and previous pelvic surgery were not accepted as a contraindication for VH. Demographic characteristics, primary diagnosis, uterine weight, operation time, intraoperative blood loss, complications, and hospital stay and cost in both groups were compared. Groups were similar with respect to demographic features and primary indications. Mean uterine weight and mean operation time were similar in VH and AH groups (258.0 g vs 293.9 g and 93.7 min vs 101.4 min, respectively). Oopherectomy was performed in 44.7% of VH and in 83.6% of AH. Colporrhaphies and/or anti-incontinence surgery were performed in 15 patients in the VH group (31.9%). The intraoperative blood loss was lower in the VH group than the AH group (245.0 mL vs 408.6 mL, P < 0.001). Perioperative complications were increased with AHs. The mean hospital stay and operation cost in the VH group were significantly less than the AH group (P < 0.001). This study indicates that vaginal hysterectomy could be performed with less morbidity in patients with benign gynecologic diseases even in large, immobile uterus and previous pelvic surgery.
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... Selim Serter, Güliz Yılmaz, Tevfik Güvenal, Ali Rıza Kandiloğlu, Gökhan Pekindil Radyoloji Anabilim Dalı (Yrd. Doç. Dr. S. Serter, Arş. ... Dr. T. Güvenal); Patoloji Anabilim Dalı (Prof. Dr. AR Kandiloğlu), Celal Bayar Üniversitesi... more
... Selim Serter, Güliz Yılmaz, Tevfik Güvenal, Ali Rıza Kandiloğlu, Gökhan Pekindil Radyoloji Anabilim Dalı (Yrd. Doç. Dr. S. Serter, Arş. ... Dr. T. Güvenal); Patoloji Anabilim Dalı (Prof. Dr. AR Kandiloğlu), Celal Bayar Üniversitesi Tıp Fakültesi, TR-45020 Manisa Özet Amaç. ...
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To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Thirteen healthcare centers in Turkey... more
To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients. Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 ± 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n=13). Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially.
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Pubovaginal sling procedures are being performed with increased frequency for stress urinary incontinence. The vaginal wall sling was introduced in 1989 by Raz et al., and itssuccess rate has been reported as being 61%–100%. A number of... more
Pubovaginal sling procedures are being performed with increased frequency for stress urinary incontinence. The vaginal wall sling was introduced in 1989 by Raz et al., and itssuccess rate has been reported as being 61%–100%. A number of recent studies have identified that some patient factors may influence the likelihood of a successful outcome. In the present study, we evaluated whether preoperative Valsalva leak-point pressure and urethral pressure profile can be used as predictors of success after surgery. We identified the preoperative characteristics of 58 women who underwent an isolated in situ anterior vaginal wall sling procedure by the same surgeon. Patients' ages, previous anti-incontinence procedures, hormone replacement status and previous hysterectomies were determined and patients underwent urodynamics, including cystometry, measurement of the Valsalva leak-point pressure and urethral pressure profile (maximal urethral pressure). After the vaginal wall sling procedure, success was defined as a significant improvement in stress urinary incontinence symptoms or no symptoms at all. The 58 women ranged from41 to–71 years old (average 52.3) and average follow-up was 26 months (range 16–34). An anti-incontinence procedure had been done previously in 15% of cases. The success rate was 65.4% in patients with Valsalva leak-point pressure < 50 cmH2Oand maximal urethral pressure < 30 cmH2O, but it was 90.6% in patients with Valsalva leak-point pressure 50 cmH2O or higher and maximal urethral pressure 30 cmH2O or more. Patients with Valsalva leak-point pressure 50 cmH2O or higher and maximal urethral pressure 30 cmH2O or more had a 90.6% success rate, and it was significantly higher than the success rate of patients with lower values for both parameters. We concluded that preoperative Valsalva leak-point pressure and maximal urethral pressure can be used to estimate the success rate of anterior vaginal wall sling procedures. When of these parameters are concurrently high, the outcome of surgery seems more favorable.
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Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin... more
Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin system in humans, we examined whether leptin concentrations in the mother and the newborn correlate with the weight of mother, placenta and newborn. A total of 88 pregnant women at 38–42 weeks’ gestation were studied. All infants were categorized as small for gestational age (SGA) (n=16), average for gestational age (AGA) (n=59) or large for gestational age (LGA) (n=13). Leptin, zinc, and copper levels were measured in maternal and cord serum at birth. Maternal BMI and placental weight of the LGA groups were significantly higher than those of the SGA and AGA groups. Cord and maternal leptin levels of the SGA groups were significantly lower than those of the AGA and LGA groups. Maternal serum leptin levels were positively correlated with BMI and maternal zinc levels in all groups. Cord serum leptin levels of all groups were positively correlated with birth weight and placental weight. Birth weight was negatively correlated with maternal and cord copper level of all groups. Umbilical leptin concentrations of SGA newborns correlated with leptin concentrations of their mothers. In all pregnancies, birth weight increases in association with increase in cord leptin level. Our results suggest that maternal zinc but not copper level has an effect on maternal serum leptin levels. The increase in copper level in both maternal and cord blood may contribute to restriction in fetal growth. La leptina y el zinc están implicados en la regulación del apetito. El cobre es un oligoelemento que regula las funciones de varios cuproenzimas esenciales para la vida. Para evaluar la relación entre los niveles de zinc, cobre y leptina en los humanos, se estudió en embarazos a término si la concentración de leptina, zinc y cobre en la madre y el recién nacido se correlacionaba con el peso materno, el de la placenta y del recién nacido. Se estudiaron 88 mujeres gestantes de 38–42 semanas y se agruparon según el peso al nacer de los recién nacidos en pequeños (P) para la edad gestacional (n=16), medianos (M; n=59) y grandes (G; n=13). Se determinaron los niveles de leptina, zinc y cobre en la sangre materna y en la del cordón umbilical al nacimiento. El índice de masa corporal (BMI) materoo y el peso de la placenta correspondiente al grupo G fueron significativamente mayores que en los otros grupos y los niveles de leptina maternos y del cordón fueron significativamente menores en el grupo P. Los niveles séricos maternos de leptina se correlacionaron positivamente con los valores maternos de zinc y el del BMI en todos los grupos. Los niveles de leptina en la sangre del cordón se correlacionaron positivamente con el peso de la placenta y del recién nacido en todos los grupos. El peso al nacimiento secorrelacionó negativamente con el nivel de cobre en sangre materna y la del cordón de todos los grupos. Las concentraciones umbilicales de leptina en el grupo P se correlacionaron con las de la correspondiente sangre materna. En todos los embarazos, el peso del recién nacido aumentó en relación con el incremento de la concentración umbilical de leptina. Los resultados sugieren que el zinc materno, no el cobre, influye sobre el nivel de leptina materna y que el nivel de cobre en sangre materna y umbilical podría contribuir a la restricción del peso fetal.
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Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin... more
Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin system in humans, we examined whether leptin concentrations in the mother and the newborn correlate with the weight of mother, placenta and newborn. A total of 88 pregnant women at 38–42 weeks’ gestation were studied. All infants were categorized as small for gestational age (SGA) (n=16), average for gestational age (AGA) (n=59) or large for gestational age (LGA) (n=13). Leptin, zinc, and copper levels were measured in maternal and cord serum at birth. Maternal BMI and placental weight of the LGA groups were significantly higher than those of the SGA and AGA groups. Cord and maternal leptin levels of the SGA groups were significantly lower than those of the AGA and LGA groups. Maternal serum leptin levels were positively correlated with BMI and maternal zinc levels in all groups. Cord serum leptin levels of all groups were positively correlated with birth weight and placental weight. Birth weight was negatively correlated with maternal and cord copper level of all groups. Umbilical leptin concentrations of SGA newborns correlated with leptin concentrations of their mothers. In all pregnancies, birth weight increases in association with increase in cord leptin level. Our results suggest that maternal zinc but not copper level has an effect on maternal serum leptin levels. The increase in copper level in both maternal and cord blood may contribute to restriction in fetal growth. La leptina y el zinc están implicados en la regulación del apetito. El cobre es un oligoelemento que regula las funciones de varios cuproenzimas esenciales para la vida. Para evaluar la relación entre los niveles de zinc, cobre y leptina en los humanos, se estudió en embarazos a término si la concentración de leptina, zinc y cobre en la madre y el recién nacido se correlacionaba con el peso materno, el de la placenta y del recién nacido. Se estudiaron 88 mujeres gestantes de 38–42 semanas y se agruparon según el peso al nacer de los recién nacidos en pequeños (P) para la edad gestacional (n=16), medianos (M; n=59) y grandes (G; n=13). Se determinaron los niveles de leptina, zinc y cobre en la sangre materna y en la del cordón umbilical al nacimiento. El índice de masa corporal (BMI) materoo y el peso de la placenta correspondiente al grupo G fueron significativamente mayores que en los otros grupos y los niveles de leptina maternos y del cordón fueron significativamente menores en el grupo P. Los niveles séricos maternos de leptina se correlacionaron positivamente con los valores maternos de zinc y el del BMI en todos los grupos. Los niveles de leptina en la sangre del cordón se correlacionaron positivamente con el peso de la placenta y del recién nacido en todos los grupos. El peso al nacimiento secorrelacionó negativamente con el nivel de cobre en sangre materna y la del cordón de todos los grupos. Las concentraciones umbilicales de leptina en el grupo P se correlacionaron con las de la correspondiente sangre materna. En todos los embarazos, el peso del recién nacido aumentó en relación con el incremento de la concentración umbilical de leptina. Los resultados sugieren que el zinc materno, no el cobre, influye sobre el nivel de leptina materna y que el nivel de cobre en sangre materna y umbilical podría contribuir a la restricción del peso fetal.
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Introduction The purpose of this study was to compare the effects of different postmenopausal hormone therapy regimens, namely conjugated equine estrogens (CEE), CEE plus medroxyprogesterone acetate (MPA), tibolone, and raloxifene on... more
Introduction The purpose of this study was to compare the effects of different postmenopausal hormone therapy regimens, namely conjugated equine estrogens (CEE), CEE plus medroxyprogesterone acetate (MPA), tibolone, and raloxifene on cerebral blood flow and cognitive functions. Methods A total of 64 healthy postmenopausal women admitted to the Department of Obstetrics and Gynecology, Cumhuriyet University, Turkey were included in this study. Patients were divided into five groups with respect to the treatment protocols: CEE 0.625 mg/day (n=13); CEE 0.625 mg/day + MPA 2.5 mg/day (n=14); tibolone 2.5 mg/day (n=11); raloxifene 60 mg/day (n=9); and control (n=17). The CEE group included only women with surgical menopause. Those who were on hormonal therapy, who had previously used hormonal therapy, who had neurological disorders, or who did not accept the longterm follow-up were excluded from the study. Demographic and clinic characteristics were recorded. Before starting the therapy regimens, cerebral blood flow was evaluated by internal carotid artery and middle cerebral artery peak systolic velocity, and pulsatility index measurements via Doppler ultrasonography. Cognitive functions were evaluated by the Standardized Mini-Mental Test. The mean follow-up period was 10.9±2.4 months, ranging between 8 and 16 months. After the follow-up period, the cerebral blood flow, and cognitive function of each woman was re-evaluated. Results Demographic and clinical characteristics of the women were not significantly different between the study groups (P>0.05). There were no significant differences between the pretreatment and posttreatment values for cerebral blood flow indices and cognitive function scores in any of the study groups (P>0.05). Conclusion Different postmenopausal hormone therapy regimens have not revealed any significant effects on either cerebral blood flow or cognitive function.
Research Interests: Cognition, Turkey, Postmenopausal Women, Humans, Ultrasonography, and 16 moreFemale, Therapy, Follow-up studies, Pulsatility Index, Middle Aged, Adult, Analysis of Variance, Cognitive Function, Chi Square Distribution, Hormone Therapy, Cerebral Blood Flow, Blood Flow Velocity, Middle Cerebral Artery, Internal Carotid Artery, Medroxyprogesterone Acetate, and Raloxifene
The goal of this study is to evaluate the effect of glyceryl trinitrate (GTN) in the management of hypertension in women with preeclampsia, eclampsia, and HELLP syndrome. Fifty five women with preeclampsia, eclampsia, and HELLP syndrome... more
The goal of this study is to evaluate the effect of glyceryl trinitrate (GTN) in the management of hypertension in women with preeclampsia, eclampsia, and HELLP syndrome. Fifty five women with preeclampsia, eclampsia, and HELLP syndrome administered GTN infusion for the management of hypertension were studied. Demographic, clinical, and perinatal outcome findings were collected for analyses. We recorded initial and maintenance doses of GTN, and duration of its use in prepartum and postpartum periods. We collected systolic and diastolic blood pressures (BPs) at admission and before the administration of GTN infusion. During the GTN infusion, we calculated average diastolic and systolic blood pressures 6 hours apart on the first day, 12 hours apart on the second day, and 24 hours apart on the third day. Of 55 women, 24 with severe preeclampsia, 16 with HELLP syndrome, and 15 with eclampsia were included in this study. In severe preeclampsia group, GTN infusion significantly reduced systolic and diastolic BPs beginning from the second quarter and third quarter, respectively, of first day (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In the HELLP syndrome group, GTN infusion significantly decreased systolic and diastolic blood pressures beginning from the third quarter and second quarter, respectively, of the first day (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In the eclampsia group, GTN infusion significantly reduced systolic and diastolic blood pressures beginning from the third quarter and first quarter, respectively, of the first day (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In women with severe preeclampsia, eclampsia, and HELLP syndrome, infusion of GTN can be used as an alternative agent to well-known drugs and causes no significant adverse effect to the mother and fetus.
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Research Interests: Chitosan, Biological Sciences, Humans, Fertility and Sterility, Female, and 18 moreAnimals, Recurrence, Clinical Sciences, Gels, Pilot study, Experimental, Rats, Adhesions, Adult, Public health systems and services research, Spermine, Wistar Rats, Nitrogen Oxides, Pilot Projects, Chitin, Laparoscopy, Postoperative Complications, and Severity of Illness Index
To evaluate the histopathological effects of tubal ligation on ovary and endometrium in a rat model. Twenty-four female Wistar albino rats weighing 220-260 g were used. The rats were assigned randomly into tubal ligation and control... more
To evaluate the histopathological effects of tubal ligation on ovary and endometrium in a rat model. Twenty-four female Wistar albino rats weighing 220-260 g were used. The rats were assigned randomly into tubal ligation and control groups. While tubal ligation was applied to the first group of rats, only a laparotomy was performed in the second group. Six weeks later, a second laparotomy was performed and uterine horns and ovaries of the rats in the two groups were excised for histopathological assessment. A pathologist blinded to the groups made histopathological examination including quantification of endometrial phases, presence of endometrial inflammation and counting the number of tertiary follicles and corpora lutea in each ovary. We found no significant difference between tubal ligation and control groups related to the number of tertiary follicles and corpora lutea (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). However, in the tubal ligation group, endometrial inflammatory infiltration was significantly higher than in the control group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Tubal ligation does not affect ovarian histology as an indicator of ovarian function. However, endometrial inflammation may occur after tubal ligation and lead to menstrual irregularities as an early complication.
Research Interests:
We investigated the effects of spermine NONOate (SPER/NO), diethylenetriamine NONOate (DETA/NO) and methylene blue for preventing postoperative adhesion in a rat uterine horn model. Before operations, rats were randomly assigned into 6... more
We investigated the effects of spermine NONOate (SPER/NO), diethylenetriamine NONOate (DETA/NO) and methylene blue for preventing postoperative adhesion in a rat uterine horn model. Before operations, rats were randomly assigned into 6 groups, each composed of 12 rats. These were the sham, control, normal saline, SPER/NO, DETA/NO and methylene blue groups. Each rat was anesthetized with ketamine hydrochloride (40 mg/kg i.v.). The abdominal wall was shaved; the surgical site was scrubbed with povidone iodine and rinsed with sterile saline 3 times before surgery. Under sterile conditions, a 3-cm vertical midline incision was made in all groups. In the sham group, we closed the abdominal wall without any procedure. In the other groups, a 2-cm segment of each uterine horn was injured in 10 spots on the antimesenteric surface using unipolar cautery. Before the final abdominal closure, no adjuvant therapy was administered intraperitoneally to the rats in the control group; 2 ml of normal saline solution, 1% methylene blue solution, SPER/NO (0.5 mg/ml) and DETA/NO (0.1 mg/ml) were instilled into the uterine horns of the rats in the respective groups. The incision was closed with a running 4-0 monofilament delayed absorbable suture in a single layer of muscle and fascia in a running pattern, excluding the peritoneum, and in the covering layer of skin in an interrupted pattern, in all groups. Two weeks after the surgery, all animals were killed, second laparotomies were performed, and the extent and severity of adhesions were determined by a blinded examiner. The adhesion scores of the sham group were significantly lower than those of the other groups (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In the methylene blue, SPER/NO and DETA/NO groups, adhesion scores were significantly lower than in the normal saline and control groups (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). However, there were no significant differences related to the extent and severity scores of adhesions between the methylene blue, SPER/NO and DETA/NO groups (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). This study showed that SPER/NO, DETA/NO and methylene blue administered at the end of surgery reduced the adhesion formation in a rat uterine horn model.
Research Interests:
Research Interests:
To evaluate the histopathological effects of tubal ligation on ovary and endometrium in a rat model. Twenty-four female Wistar albino rats weighing 220-260 g were used. The rats were assigned randomly into tubal ligation and control... more
To evaluate the histopathological effects of tubal ligation on ovary and endometrium in a rat model. Twenty-four female Wistar albino rats weighing 220-260 g were used. The rats were assigned randomly into tubal ligation and control groups. While tubal ligation was applied to the first group of rats, only a laparotomy was performed in the second group. Six weeks later, a second laparotomy was performed and uterine horns and ovaries of the rats in the two groups were excised for histopathological assessment. A pathologist blinded to the groups made histopathological examination including quantification of endometrial phases, presence of endometrial inflammation and counting the number of tertiary follicles and corpora lutea in each ovary. We found no significant difference between tubal ligation and control groups related to the number of tertiary follicles and corpora lutea (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). However, in the tubal ligation group, endometrial inflammatory infiltration was significantly higher than in the control group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Tubal ligation does not affect ovarian histology as an indicator of ovarian function. However, endometrial inflammation may occur after tubal ligation and lead to menstrual irregularities as an early complication.