Molecular basis of receptor/G-protein-coupling selectivity (Q77795096)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9888696%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

review article

1 reference

title

Molecular basis of receptor/G-protein-coupling selectivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9888696%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

J Wess

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8 December 2019

publication date

1 December 1998

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Pharmacology & Therapeutics

8 December 2019

published in

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8 December 2019

volume

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8 December 2019

issue

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8 December 2019

page(s)

231-264

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Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin

8 December 2019

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Transducin-alpha C-terminal peptide binding site consists of C-D and E-F loops of rhodopsin

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Constitutive activation of opsin: influence of charge at position 134 and size at position 296.

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Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors

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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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Pharmacology and functions of metabotropic glutamate receptors

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Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function

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7 January 2021

Expanding horizons for receptors coupled to G proteins: diversity and disease

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

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Efficient Interaction with a Receptor Requires a Specific Type of Prenyl Group on the G Protein γ Subunit

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Three cytoplasmic loops of rhodopsin interact with transducin

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Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits

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Binding of alpha- and betagamma-subunits of G0 to beta1-adrenoceptor in sealed unilamellar lipid vesicles

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7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

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Identification of receptor-activated G proteins: selective immunoprecipitation of photolabeled G-protein alpha subunits.

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The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

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7 January 2021

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex

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7 January 2021

Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family

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7 January 2021

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

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Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis

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The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling

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7 January 2021

G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes

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7 January 2021

Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Interaction of Transducin with Light-activated Rhodopsin Protects It from Proteolytic Digestion by Trypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Differential Coupling of m2 and m4 Muscarinic Receptors to Inhibition of Adenylyl Cyclase by Giα and Goα Subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Signal sorting by G-protein-linked receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Biochemical approaches to examine the specificity of interactions between receptors and guanine nuclotide binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Specific Gq protein involvement in muscarinic M3 receptor-induced phosphatidylinositol hydrolysis and Ca2+ release in mouse duodenal myocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Receptor regulation of G-protein palmitoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Multisite contacts involved in coupling of the beta-adrenergic receptor with the stimulatory guanine-nucleotide-binding regulatory protein. Structural and functional studies by beta-receptor-site-specific synthetic peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The second intracellular loop of the alpha2-adrenergic receptors determines subtype-specific coupling to cAMP production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Heterotrimeric G proteins: organizers of transmembrane signals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Membrane organization in G-protein mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Mutational analysis of the mouse 5-HT7 receptor: importance of the third intracellular loop for receptor-G-protein interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Palmitoylation of human endothelinB. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Identification of A2a adenosine receptor domains involved in selective coupling to Gs. Analysis of chimeric A1/A2a adenosine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

A common step for signal transduction in G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The effect of carboxyl-terminal mutagenesis of Gt alpha on rhodopsin and guanine nucleotide binding

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Activation of the alpha1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Activating mutations of rhodopsin and other G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Isolation of cDNA Clones Encoding Eight Different Human G Protein γ Subunits, Including Three Novel Forms Designated the γ4, γ10, and γ11 Subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Structural and functional relationships of heterotrimeric G‐proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Regulation of phosphoinositide-specific phospholipase C isozymes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Constitutively active mutants of rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Protein modification. Palmitoylation in G-protein signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

A domain for G protein coupling in carboxyl-terminal tail of rat angiotensin II receptor type 1A

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Projection structure of rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Splice variants of the human EP3 receptor for prostaglandin E2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Locating ligand-binding sites in 7TM receptors by protein engineering.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Gonadotrophin-releasing hormone receptor agonist-mediated down-regulation of Gq alpha/G11 alpha (pertussis toxin-insensitive) G proteins in alpha T3-1 gonadotroph cells reflects increased G protein turnover but not alterations in mRNA levels

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G protein-coupled receptor structure and function: the impact of disease-causing mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Mapping of G protein coupling sites of the angiotensin II type 1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Differential signal transduction by five splice variants of the PACAP receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Defects in G protein-coupled signal transduction in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Regulation of Gq/11 by the Gonadotropin-Releasing Hormone Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Structure and function of G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Complexity and diversity of mammalian adenylyl cyclases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Receptor and membrane interaction sites on Gbeta. A receptor-derived peptide binds to the carboxyl terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Role of amino- and carboxyl-terminal regions of G(alphaZ) in the recognition of Gi-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Arrangement of rhodopsin transmembrane α-helices

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Molecular Architecture of G Protein-Coupled Receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Basic amino acids at the C-terminus of the third intracellular loop are required for the activation of phospholipase C by cholecystokinin-B receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Ribozyme-mediated suppression of the G protein gamma7 subunit suggests a role in hormone regulation of adenylylcyclase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Activation and depalmitoylation of Gs alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Lipid modifications of trimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Functional characterization of five V2 vasopressin receptor gene mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Molecular biology of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Measurement of receptor-stimulated guanosine 5'-O-(gamma-thio)triphosphate binding by G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Degradation of G11 alpha/Gq alpha is accelerated by agonist occupancy of alpha 1A/D, alpha 1B, and alpha 1C adrenergic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Differential targeting and retention of G protein-coupled receptors in polarized epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G protein-coupled signal transduction pathways for interleukin-8

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

First intracellular loop of the human cholecystokinin-A receptor is essential for cyclic AMP signaling in transfected HEK-293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position-specific effects in transducin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Role of the prenyl group on the G protein gamma subunit in coupling trimeric G proteins to A1 adenosine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

Three-Dimensional Structure of the Cytoplasmic Face of the G Protein Receptor Rhodopsin†

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The First and Second Cytoplasmic Loops of the G-Protein Receptor, Rhodopsin, Independently Form β-Turns†

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900030-8

7 January 2021

10.1016/S0163-7258(98)00030-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9888696%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9888696%20AND%20SRC:MED&resulttype=core&format=json