Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. (Q40024347)

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1 January 2020

title

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway (English)

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1 January 2020

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W Zhang

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M Konopleva

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1 January 2020

V R Ruvolo

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1 January 2020

T McQueen

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R L Evans

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1 January 2020

W G Bornmann

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J Cortes

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M Andreeff

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language of work or name

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17 January 2008

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1 January 2020

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Targeting RAS signalling pathways in cancer therapy

1 January 2020

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

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The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors

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Antitumor activity of sorafenib in FLT3-driven leukemic cells

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

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7 January 2021

Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating genes

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7 January 2021

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

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7 January 2021

Haematopoietic response and bcl-2 expression in patients with acute myeloid leukaemia.

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2405098

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Dimensions Publication ID

1 January 2020

1010089388

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