Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia (Q40400934)

20 September 2017

title

Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia (English)

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20 September 2017

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Ricciardi MR

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20 September 2017

McQueen T

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20 September 2017

Chism D

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20 September 2017

Milella M

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20 September 2017

Estey E

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20 September 2017

Kaldjian E

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20 September 2017

Sebolt-Leopold J

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20 September 2017

Konopleva M

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20 September 2017

Andreeff M

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20 September 2017

publication date

1 September 2005

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20 September 2017

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

1543-1549

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Mechanisms of resistance to apoptosis in human AML blasts: the role of differentiation-induced perturbations of cell-cycle checkpoints.

20 September 2017

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CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

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Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors.

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Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events

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Magnetic relaxation switches capable of sensing molecular interactions

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Flow cytometric detection of total and serine 473 phosphorylated Akt.

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Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo

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Kinetics of engraftment of CD34− and CD34+ cells from mobilized blood differs from that of CD34− and CD34+ cells from bone marrow

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Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cells

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

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Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

21 January 2018

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Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

21 January 2018

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Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

21 January 2018

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Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

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Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

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21 January 2018

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

21 January 2018

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Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects

21 January 2018

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Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

21 January 2018

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7 January 2021

Detection of intracellular phosphorylated STAT-1 by flow cytometry

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7 January 2021

An inhibitor of PI3-K differentially affects proliferation and IL-6 protein secretion in normal and leukemic myeloid cells depending on the stage of differentiation

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7 January 2021

Functional and kinetic characterization of granulocyte colony-stimulating factor-primed CD34- human stem cells

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7 January 2021

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

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7 January 2021

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

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7 January 2021

Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403859

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Dimensions Publication ID

20 September 2017

1037939927

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