Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan. (Q35154587)

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English	Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan.	scientific article

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2 March 2020

Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan (English)

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2 March 2020

viral quasispecies

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2 March 2020

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Kazuhiko Koike

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2 March 2020

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Satoshi Kimura

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Hiroshi Yotsuyanagi

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Takeya Tsutsumi

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Hiroyuki Gatanaga

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Hirotaka Ode

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Wataru Sugiura

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Kyoji Moriya

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Shinichi Oka

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6 March 2015

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2 March 2020

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6 March 2015

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Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir

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Hepatitis C Virus (HCV) NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection

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Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study

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Global distribution and prevalence of hepatitis C virus genotypes

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13 July 2018

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Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial

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Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment

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HCV direct-acting antiviral agents: the best interferon-free combinations

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13 July 2018

Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir

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13 July 2018

Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients

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Mutational and fitness landscapes of an RNA virus revealed through population sequencing

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Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial

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Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection

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Empirical validation of viral quasispecies assembly algorithms: state-of-the-art and challenges

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Once-daily simeprevir (TMC435) with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1-infected patients in Japan: the DRAGON study

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Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-naïve genotype 1 hepatitis C: the randomized PILLAR study

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13 July 2018

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.

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Probabilistic inference of viral quasispecies subject to recombination

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13 July 2018

Benchmarking of viral haplotype reconstruction programmes: an overview of the capacities and limitations of currently available programmes

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Read length versus depth of coverage for viral quasispecies reconstruction

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Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

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Highly sensitive and specific detection of rare variants in mixed viral populations from massively parallel sequence data

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New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials

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In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

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2015PLoSO..1019145O

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