Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. (Q34807777)

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31 October 2019

title

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice (English)

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31 October 2019

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31 October 2019

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31 October 2019

Ton N M Schumacher

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31 October 2019

John B A G Haanen

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31 October 2019

Barbara J Johnson

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31 October 2019

Elaine O Costelloe

series ordinal

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31 October 2019

David R Fitzpatrick

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31 October 2019

language of work or name

English

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publication date

24 February 2003

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Proceedings of the National Academy of Sciences of the United States of America

31 October 2019

published in

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31 October 2019

volume

100

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31 October 2019

issue

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31 October 2019

page(s)

2657-2662

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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

31 October 2019

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Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responses

8 July 2018

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A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge

8 July 2018

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

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The activated type 1-polarized CD8(+) T cell population isolated from an effector site contains cells with flexible cytokine profiles.

8 July 2018

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Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

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8 July 2018

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Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8+ T cells

8 July 2018

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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

8 July 2018

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Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.

8 July 2018

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Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

8 July 2018

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Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection

8 July 2018

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In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

8 July 2018

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A single peripheral CD8+ T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

8 July 2018

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Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection.

8 July 2018

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In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue

8 July 2018

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8 July 2018

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Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

8 July 2018

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

21 January 2018

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21 January 2018

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21 January 2018

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The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation

21 January 2018

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A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression

21 January 2018

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Recruitment and proliferation of CD8+ T cells in respiratory virus infections.

21 January 2018

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Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

26 October 2018

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In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

21 January 2018

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12 December 2020

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity

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12 December 2020

Inactivation and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH

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12 December 2020

Systemic T cell expansion during localized viral infection

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12 December 2020

Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0538056100

1 reference

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31 October 2019

0 references

1 reference

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31 October 2019

PubMed publication ID

12601154

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12601154%20AND%20SRC:MED&resulttype=core&format=json