Inactivation and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH (Q73707598)

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6 November 2019

title

Inactivation and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH (English)

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6 November 2019

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T Kataoka

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6 November 2019

K Togashi

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6 November 2019

H Takayama

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6 November 2019

K Takaku

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6 November 2019

K Nagai

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6 November 2019

publication date

1 July 1997

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6 November 2019

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6 November 2019

volume

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6 November 2019

issue

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6 November 2019

page(s)

493-500

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Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity

6 November 2019

cites work

1 reference

12 December 2020

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.

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Granzymes: exogenous proteinases that induce target cell apoptosis.

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Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity

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Identification of low molecular weight probes on perforin- and Fas-based killing mediated by cytotoxic T lymphocytes

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12 December 2020

Estimation of pH and the number of lytic granules in a CD8+ CTL clone treated with an inhibitor of vacuolar type H(+)-ATPase concanamycin A

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Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

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Hybrid antibodies can target sites for attack by T cells

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Cytotoxic granules from killer cells: specificity of granules and insertion of channels of defined size into target membranes

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12 December 2020

Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis

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12 December 2020

Acidification of the endocytic and exocytic pathways

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12 December 2020

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

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12 December 2020

A family of serine esterases in lytic granules of cytolytic T lymphocytes

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12 December 2020

Co-sedimentation of chondroitin sulfate A glycosaminoglycans and proteoglycans with the cytolytic secretory granules of rat large granular lymphocyte (LGL) tumor cells, and identification of a mRNA in normal and transformed LGL that encodes proteogl

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12 December 2020

Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3.

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Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans

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12 December 2020

Cell damage by cytolysin. Spontaneous recovery and reversible inhibition by divalent cations.

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12 December 2020

Perforin-mediated target cell lysis by cytolytic T lymphocytes

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12 December 2020

The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

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12 December 2020

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

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12 December 2020

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

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12 December 2020

The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors

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12 December 2020

A central role of perforin in cytolysis?

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12 December 2020

Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones

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12 December 2020

Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification

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12 December 2020

Proteases and lymphocyte cytotoxic killing mechanisms

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12 December 2020

Changes in free calcium in the endoplasmic reticulum of living cells detected using targeted aequorin

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12 December 2020