Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. (Q34624894)

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30 December 2019

review article

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title

Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses (English)

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30 December 2019

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30 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473844%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Kate L Jeffrey

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Christian Rommel

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30 December 2019

publication date

1 May 2007

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Nature Reviews Drug Discovery

30 December 2019

published in

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30 December 2019

volume

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30 December 2019

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391-403

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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

30 December 2019

cites work

1 reference

Targeting signal transduction as a strategy to treat inflammatory diseases.

31 March 2020

1 reference

A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.

31 March 2020

1 reference

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

31 March 2020

1 reference

Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.

31 March 2020

1 reference

MAP kinases in the immune response

31 March 2020

1 reference

Mitogen-activated protein kinases in apoptosis regulation

31 March 2020

1 reference

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

31 March 2020

1 reference

Mammalian MAP kinase signalling cascades

31 March 2020

1 reference

The role of erk1 and erk2 in multiple stages of T cell development

31 March 2020

1 reference

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte

31 March 2020

1 reference

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

31 March 2020

1 reference

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

31 March 2020

1 reference

Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses

31 March 2020

1 reference

The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses

31 March 2020

1 reference

Molecular mechanisms regulating Th1 immune responses

31 March 2020

1 reference

Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells

31 March 2020

1 reference

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

31 March 2020

1 reference

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

31 March 2020

1 reference

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

31 March 2020

1 reference

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

31 March 2020

1 reference

JNK phosphorylates paxillin and regulates cell migration

31 March 2020

1 reference

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

31 March 2020

1 reference

MAP kinases and cell migration

31 March 2020

1 reference

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

31 March 2020

1 reference

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

31 March 2020

1 reference

ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation.

31 March 2020

1 reference

Feedback regulation of lymphocyte signalling

31 March 2020

1 reference

Feedback control of the protein kinase TAK1 by SAPK2a/p38

31 March 2020

1 reference

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.

31 March 2020

1 reference

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

31 March 2020

1 reference

Molecular interpretation of ERK signal duration by immediate early gene products

31 March 2020

1 reference

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

31 March 2020

1 reference

Subcellular localization determines MAP kinase signal output.

31 March 2020

1 reference

MAPK-regulated transcription: a continuously variable gene switch?

31 March 2020

1 reference

MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src.

31 March 2020

1 reference

Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta

31 March 2020

1 reference

Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors

31 March 2020

1 reference

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

31 March 2020

1 reference

Phosphorylation and regulation of Raf by Akt (protein kinase B)

31 March 2020

1 reference

Hydrogen peroxide as second messenger in lymphocyte activation

31 March 2020

1 reference

Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene

31 March 2020

1 reference

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

31 March 2020

1 reference

Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling

31 March 2020

1 reference

The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade

31 March 2020

1 reference

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

31 March 2020

1 reference

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

1 reference

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

31 March 2020

1 reference

MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

31 March 2020

1 reference

MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein

31 March 2020

1 reference

Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal

31 March 2020

1 reference

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

31 March 2020

1 reference

Dual specificity phosphatases: a gene family for control of MAP kinase function.

31 March 2020

1 reference

Protein tyrosine phosphatases in the human genome

31 March 2020

1 reference

A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

31 March 2020

1 reference

Dual-specificity phosphatases as targets for antineoplastic agents

31 March 2020

1 reference

Protein phosphatases and the regulation of MAP kinase activity

31 March 2020

1 reference

From form to function: signaling by protein tyrosine phosphatases.

31 March 2020

1 reference

Combinatorial control of the specificity of protein tyrosine phosphatases

31 March 2020

1 reference

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

31 March 2020

1 reference

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

31 March 2020

1 reference

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

31 March 2020

1 reference

31 March 2020

MAP kinase phosphatases

1 reference

An emerging family of dual specificity MAP kinase phosphatases

31 March 2020

1 reference

The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases

31 March 2020

1 reference

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

31 March 2020

1 reference

Expression cloning of a human dual-specificity phosphatase

31 March 2020

1 reference

A novel human ERK phosphatase regulates H-ras and v-raf signal transduction.

31 March 2020

1 reference

Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence

31 March 2020

1 reference

Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway

31 March 2020

1 reference

A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway

31 March 2020

1 reference

Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10.

31 March 2020

1 reference

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

31 March 2020

1 reference

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

31 March 2020

1 reference

Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5

31 March 2020

1 reference

Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4

31 March 2020

1 reference

The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development

31 March 2020

1 reference

The dual specificity phosphatase transcriptome of the murine thymus

31 March 2020

1 reference

Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12

31 March 2020

1 reference

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

31 March 2020

1 reference

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal

31 March 2020

1 reference

Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis

31 March 2020

1 reference

MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

31 March 2020

1 reference

Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase

31 March 2020

1 reference

Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1

31 March 2020

1 reference

Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP

31 March 2020

1 reference

New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding

31 March 2020

1 reference

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

31 March 2020

1 reference

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs

31 March 2020

1 reference

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

31 March 2020

1 reference

Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo

31 March 2020

1 reference

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

31 March 2020

1 reference

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

31 March 2020

1 reference

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

31 March 2020

1 reference

Dual-specificity phosphatase 1 and serum/glucocorticoid-regulated kinase are downregulated in prostate cancer.

31 March 2020

1 reference

Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer

31 March 2020

1 reference

Abrogation of DUSP6 by hypermethylation in human pancreatic cancer

31 March 2020

1 reference

The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma

31 March 2020

1 reference

Characterization of a variant of PAC-1 in large granular lymphocyte leukemia

31 March 2020

1 reference

Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells

31 March 2020

1 reference

Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia

31 March 2020

1 reference

A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity

31 March 2020

1 reference

The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation

31 March 2020

1 reference

p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements

31 March 2020

1 reference

The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.

31 March 2020

1 reference

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

31 March 2020

1 reference

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

31 March 2020

1 reference

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

31 March 2020

1 reference

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

31 March 2020

1 reference

Crystal structure of human protein tyrosine phosphatase 1B

31 March 2020

1 reference

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

31 March 2020

1 reference

Modular structure of a docking surface on MAPK phosphatases

31 March 2020

1 reference

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

31 March 2020

1 reference

Molecular recognitions in the MAP kinase cascades

31 March 2020

1 reference

The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3.

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

The specificities of protein kinase inhibitors: an update

31 March 2020

1 reference

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

31 March 2020

1 reference

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

31 March 2020

1 reference

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

31 March 2020

1 reference

Essential role for ERK2 mitogen-activated protein kinase in placental development

31 March 2020

1 reference

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

31 March 2020

1 reference

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

31 March 2020

1 reference

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

31 March 2020

1 reference

p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

31 March 2020

1 reference

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

31 March 2020

1 reference

Defective T Cell Differentiation in the Absence of Jnk1

31 March 2020

1 reference

A central role for JNK in obesity and insulin resistance

31 March 2020

1 reference

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

31 March 2020

1 reference

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

31 March 2020

1 reference

The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway

31 March 2020

1 reference

The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades

31 March 2020

1 reference

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

31 March 2020

1 reference

Counting on mitogen-activated protein kinases--ERKs 3, 4, 5, 6, 7 and 8.

31 March 2020

1 reference

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

31 March 2020

1 reference

Mitogen-activated protein kinase pathways

31 March 2020

1 reference

Protein tyrosine phosphatases: from genes, to function, to disease

31 March 2020

1 reference

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase

31 March 2020

1 reference

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

31 March 2020

1 reference

CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

31 March 2020

1 reference

Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes.

31 March 2020

1 reference

MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer.

31 March 2020

1 reference

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

31 March 2020

1 reference

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

31 March 2020

1 reference

4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.

31 March 2020

1 reference

Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition

31 March 2020

1 reference

Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase

31 March 2020

1 reference

Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5

31 March 2020

1 reference

A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation

31 March 2020

1 reference

Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development

31 March 2020

1 reference

Cell-active dual specificity phosphatase inhibitors identified by high-content screening

31 March 2020

1 reference

A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region

31 March 2020

1 reference

Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.

31 March 2020

1 reference

Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10.

31 March 2020

1 reference

Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function

31 March 2020

1 reference

Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.

31 March 2020

1 reference

Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo

31 March 2020

1 reference

Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1

31 March 2020

1 reference

MKP-8, a novel MAPK phosphatase that inhibits p38 kinase

31 March 2020

1 reference

Biochemical and biological characterization of a neuroendocrine-associated phosphatase

31 March 2020

1 reference

Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2

31 March 2020

1 reference