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Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

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The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

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7 January 2021

Signal transduction. Switching off MAP kinases

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Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

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Selective interaction of JNK protein kinase isoforms with transcription factors

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The regulation of AP-1 activity by mitogen-activated protein kinases

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Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases

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Sounding the alarm: protein kinase cascades activated by stress and inflammation

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MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

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The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

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The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity

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Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

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Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

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Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

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Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

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Integration of MAP kinase signal transduction pathways at the serum response element

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A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

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Mechanism of mitogen-activated protein kinase phosphatase-3 activation by ERK2

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