Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (Q34161493)

31 July 2017

title

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. (English)

1 reference

31 July 2017

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Lionel Apetoh

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Bruce R Blazar

series ordinal

object named as

Bruce R Blazar

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31 July 2017

Vijay K Kuchroo

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31 July 2017

Ana C Anderson

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31 July 2017

Kaori Sakuishi

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31 July 2017

Jenna M Sullivan

series ordinal

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31 July 2017

language of work or name

English

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publication date

6 September 2010

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Journal of Experimental Medicine

31 July 2017

published in

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31 July 2017

volume

207

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31 July 2017

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31 July 2017

page(s)

2187-2194

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A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

5 July 2018

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PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma.

5 July 2018

1 reference

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Immune surveillance of tumors

5 July 2018

1 reference

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Cancer despite immunosurveillance: immunoselection and immunosubversion

5 July 2018

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PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

5 July 2018

1 reference

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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

5 July 2018

1 reference

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

5 July 2018

1 reference

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

5 July 2018

1 reference

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Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up.

5 July 2018

1 reference

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Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Restoring function in exhausted CD8 T cells during chronic viral infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

T cells and viral persistence: lessons from diverse infections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

The three Es of cancer immunoediting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

Viral immune evasion due to persistence of activated T cells without effector function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

CD4+Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle.

5 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100643

Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100643

Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100643

Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100643

Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947065

28 October 2018

Identifiers

DOI

10.1084/JEM.20100643

1 reference

31 July 2017

1 reference

31 July 2017

1 reference