Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities (Q34004402)

30 July 2017

title

Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities (English)

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30 July 2017

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Enerlyn Lozada

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30 July 2017

Jingjie Yi

series ordinal

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30 July 2017

Jianyuan Luo

series ordinal

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30 July 2017

David K Orren

series ordinal

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30 July 2017

publication date

26 June 2014

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

347-366

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describes a project that uses

30 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4122284/fullTextXML

inferred from PubMed Central ID database lookup

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Acetylation of WRN protein regulates its stability by inhibiting ubiquitination

5 July 2018

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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

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Acetylation regulates WRN catalytic activities and affects base excision DNA repair

5 July 2018

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Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

5 July 2018

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Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.

5 July 2018

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Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.

5 July 2018

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Direct cellular responses to platinum-induced DNA damage

5 July 2018

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Telomere dysfunction as a cause of genomic instability in Werner syndrome

5 July 2018

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Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks

5 July 2018

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Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

5 July 2018

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The role of WRN in DNA repair is affected by post-translational modifications.

5 July 2018

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The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

5 July 2018

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5 July 2018

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Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging

5 July 2018

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5 July 2018

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Cellular dynamics and modulation of WRN protein is DNA damage specific

5 July 2018

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RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

5 July 2018

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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

5 July 2018

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p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

5 July 2018

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

5 July 2018

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Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

5 July 2018

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Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

5 July 2018

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Asymmetry of DNA replication fork progression in Werner's syndrome

5 July 2018

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Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA

5 July 2018

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Chemiluminescence-based BrdU ELISA to measure DNA synthesis

5 July 2018

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Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

5 July 2018

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5 July 2018

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The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

DNA damage-induced translocation of the Werner helicase is regulated by acetylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner syndrome cells are sensitive to DNA cross-linking drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Lessons from human progeroid syndromes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner protein recruits DNA polymerase delta to the nucleolus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Functional and physical interaction between WRN helicase and human replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

The Werner syndrome protein is a DNA helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Comparative sequence analysis of ribonucleases HII, III, II PH and D

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Positional cloning of the Werner's syndrome gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Excision Repair in Mammalian Cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Mutator phenotype of Werner syndrome is characterized by extensive deletions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

5 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9506-3

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9506-3

Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9506-3

The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9506-3

Werner syndrome protein contains three structure-specific DNA binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9506-3

Werner protein stimulates topoisomerase I DNA relaxation activity

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

O6-benzylguanine and its role in chemotherapy.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122284

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

29 October 2018

1 reference

12 December 2020

DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA

1 reference

12 December 2020

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

12 December 2020

Spontaneous and induced chromosomal instability in Werner syndrome

1 reference

12 December 2020

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

12 December 2020

Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts

1 reference

12 December 2020

Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein

1 reference

12 December 2020

10.1007/S10522-014-9506-3

Identifiers

DOI

1 reference

Dimensions Publication ID

30 July 2017

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1 reference

30 July 2017

1 reference