Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity (Q24291787)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

R M Brosh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

C von Kobbe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

J A Sommers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

P Karmakar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

J Piotrowski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

I Dianova

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

G L Dianov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

V A Bohr

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

language of work or name

English

0 references

publication date

1 October 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

5791-5801

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

12 November 2019

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC125684/fullTextXML

inferred from PubMed Central ID database lookup

cites work

p53 Modulates the exonuclease activity of Werner syndrome protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Werner protein recruits DNA polymerase delta to the nucleolus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Ku complex interacts with and stimulates the Werner protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Functional and physical interaction between WRN helicase and human replication protein A

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

p53-mediated apoptosis is attenuated in Werner syndrome cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The Werner syndrome protein is a DNA helicase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The characterization of a mammalian DNA structure-specific endonuclease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Mutator phenotype of Werner syndrome is characterized by extensive deletions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Amino acid substitution matrices from protein blocks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The DNA replication fork in eukaryotic cells.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Functional interaction between Ku and the werner syndrome protein in DNA end processing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Enzymes and reactions at the eukaryotic DNA replication fork

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Positional cloning of the Werner's syndrome gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Werner syndrome cells are sensitive to DNA cross-linking drugs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Physical and functional interaction between p53 and the Werner's syndrome protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Replication focus-forming activity 1 and the Werner syndrome gene product

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Stimulation of RTH1 nuclease of the yeast Saccharomyces cerevisiae by replication protein A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Genetic syndromes in man with potential relevance to the pathobiology of aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Involvement of flap endonuclease 1 in base excision DNA repair.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

FFA-1, a protein that promotes the formation of replication centers within nuclei

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125684

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

29 November 2018

1 reference

12 December 2020

Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation

1 reference

12 December 2020

Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion

1 reference

12 December 2020

Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing

1 reference

12 December 2020

Altered frequency of initiation sites of DNA replication in Werner's syndrome cells

1 reference

12 December 2020

Growth characteristics of Werner syndrome cells in vitro

1 reference

12 December 2020

Autoradiographic studies of DNA replication in Werner's syndrome cells

1 reference

12 December 2020

ATP-independent loading of the proliferating cell nuclear antigen requires DNA ends

1 reference

12 December 2020

Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems

1 reference

12 December 2020

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

1 reference

12 December 2020

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

12 December 2020

Expansion and length-dependent fragility of CTG repeats in yeast

1 reference

12 December 2020

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

12 December 2020

Proliferating Cell Nuclear Antigen Facilitates Excision in Long-patch Base Excision Repair

1 reference

12 December 2020

RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/20.20.5791

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

release_j7dtmdpzfrfpxddkxkzeohe6nq

12 November 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/j7dtmdpzfrfpxddkxkzeohe6nq

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

11598021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11598021%20AND%20SRC:MED&resulttype=core&format=json