Delineation of WRN helicase function with EXO1 in the replicational stress response (Q33945750)

30 July 2017

title

Delineation of WRN helicase function with EXO1 in the replicational stress response (English)

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30 July 2017

Monika Aggarwal

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30 July 2017

Joshua A Sommers

series ordinal

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30 July 2017

Christa Morris

series ordinal

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30 July 2017

Robert M Brosh

series ordinal

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30 July 2017

publication date

5 May 2010

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

765-776

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describes a project that uses

30 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2893289/fullTextXML

inferred from PubMed Central ID database lookup

cites work

WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3

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c-Myc accelerates S-phase and requires WRN to avoid replication stress

5 July 2018

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Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination

5 July 2018

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5 July 2018

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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

5 July 2018

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DNA helicases Sgs1 and BLM promote DNA double-strand break resection

5 July 2018

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

5 July 2018

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

5 July 2018

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WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

5 July 2018

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5 July 2018

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Inhibition of the 5' to 3' exonuclease activity of hEXO1 by 8-oxoguanine

5 July 2018

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Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases.

5 July 2018

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Regulation of DNA double-strand break repair pathway choice

5 July 2018

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

5 July 2018

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Human premature aging, DNA repair and RecQ helicases

5 July 2018

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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

5 July 2018

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Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

5 July 2018

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Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

5 July 2018

1 reference

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The spectrum of WRN mutations in Werner syndrome patients

5 July 2018

1 reference

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Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein

5 July 2018

1 reference

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Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain

5 July 2018

1 reference

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RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination

5 July 2018

1 reference

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The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

High-resolution structure of the E.coli RecQ helicase catalytic core

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Asymmetry of DNA replication fork progression in Werner's syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Homologous recombination resolution defect in werner syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

The yeast Xrs2 complex functions in S phase checkpoint regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Differential regulation of human RecQ family helicases in cell transformation and cell cycle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Ku complex interacts with and stimulates the Werner protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

WRN helicase expression in Werner syndrome cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Werner syndrome protein contains three structure-specific DNA binding domains

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Improved flow cytometric analysis of the budding yeast cell cycle.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893289

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population

29 October 2018

1 reference

12 December 2020

Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis

1 reference

12 December 2020

A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women

1 reference

12 December 2020

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

12 December 2020

10.1016/J.DNAREP.2010.03.014

Identifiers

DOI

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30 July 2017

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30 July 2017

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