Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. (Q33799555)

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18 January 2020

review article

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2 November 2020

6 November 2020

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases (English)

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18 January 2020

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14 September 2019

regulation of gene expression

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8 September 2019

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14 September 2019

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6 November 2020

Maria Jimenez-Sanchez

series ordinal

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18 January 2020

1 reference

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18 January 2020

Maurizio Renna

1 reference

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18 January 2020

David C Rubinsztein

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18 January 2020

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English

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publication date

10 February 2010

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Journal of Biological Chemistry

18 January 2020

9 April 2010

2 references

2 November 2020

6 November 2020

8 references

25 April 2019

20 June 2019

30 June 2019

8 September 2019

14 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 November 2020

6 November 2020

285

1 reference

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18 January 2020

issue

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18 January 2020

page(s)

11061-11067

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Creative Commons Attribution-NonCommercial

18 January 2020

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30 June 2019

8 September 2019

14 September 2019

2 November 2020

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on focus list of Wikimedia project

ScienceSource

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cites work

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

4 July 2018

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Potential therapeutic applications of autophagy

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The roles of intracellular protein-degradation pathways in neurodegeneration

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

4 July 2018

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4 July 2018

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Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

4 July 2018

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4 July 2018

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4 July 2018

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

4 July 2018

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4 July 2018

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4 July 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

4 July 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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Autophagic clearance of aggregate-prone proteins associated with neurodegeneration.

21 January 2018

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The pharmacology of mTOR inhibition

21 January 2018

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Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

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Rapamycin pre-treatment protects against apoptosis

21 January 2018

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Valproate decreases inositol biosynthesis

21 January 2018

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A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

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In search of an "autophagomometer".

21 January 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

1 reference

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Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

21 January 2018

1 reference

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Dependence of hepatocytic autophagy on intracellularly sequestered calcium

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20147746

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R109.072181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

20147746

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json