ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy (Q24654787)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990316

RB1-inducible coiled-coil 1

1 reference

GOA release 2020-03-11

Unc-51 like kinase 1

1 reference

GOA release 2020-03-11

Autophagy related 13

1 reference

GOA release 2020-03-11

Ian G Ganley

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Du H Lam

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Junru Wang

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Xiaojun Ding

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She Chen

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Xuejun Jiang

Journal of Biological Chemistry

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language of work or name

English

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publication date

1 May 2009

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published in

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volume

284

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issue

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page(s)

12297-305

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cites work

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

7 April 2017

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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

7 April 2017

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7 April 2017

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Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

7 April 2017

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7 April 2017

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An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase

7 April 2017

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Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy

7 April 2017

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Rab9 GTPase regulates late endosome size and requires effector interaction for its stability

7 April 2017

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

7 April 2017

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Atg17 regulates the magnitude of the autophagic response

7 April 2017

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The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae

7 April 2017

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Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae

7 April 2017

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7 April 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

7 April 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

7 April 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

7 April 2017

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Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

7 April 2017

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Autophagy: process and function

7 April 2017

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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

7 April 2017

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

7 April 2017

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Human IRGM induces autophagy to eliminate intracellular mycobacteria

7 April 2017

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A Unified Nomenclature for Yeast Autophagy-Related Genes

7 April 2017

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Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

7 April 2017

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Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway

7 April 2017

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7 April 2017

Functions of lysosomes

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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673298

FIP200, a key signaling node to coordinately regulate various cellular processes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673298

Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673298

The molecular machinery of autophagy: unanswered questions

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673298

28 September 2017

TOR signaling in mammals

1 reference

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Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673298

ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19258318