The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins (Q28507365)

24 January 2017

title

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins (English)

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24 January 2017

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Insulin receptor substrate 1

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Ribosomal protein S6 kinase, polypeptide 1

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Thymoma viral proto-oncogene 1

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Ribosomal protein S6 kinase beta-2

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Laura S. Harrington

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24 January 2017

Greg M. Findlay

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24 January 2017

Alex Gray

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24 January 2017

Tatiana Tolkacheva

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24 January 2017

Simon Wigfield

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24 January 2017

Heike Rebholz

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24 January 2017

Jill Barnett

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24 January 2017

Nick R. Leslie

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24 January 2017

Susan Cheng

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24 January 2017

Peter R. Shepherd

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24 January 2017

Ivan Gout

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24 January 2017

C. Peter Downes

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24 January 2017

Richard F. Lamb

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24 January 2017

language of work or name

English

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publication date

19 July 2004

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24 January 2017

published in

Journal of Cell Biology

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24 January 2017

volume

166

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24 January 2017

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24 January 2017

page(s)

213–223

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

24 January 2017

cites work

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19 March 2017

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

19 March 2017

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19 March 2017

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

19 March 2017

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

19 March 2017

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19 March 2017

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Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

19 March 2017

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

19 March 2017

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

19 March 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

19 March 2017

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

19 March 2017

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Akt regulates growth by directly phosphorylating Tsc2

19 March 2017

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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

7 April 2017

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TSC2: filling the GAP in the mTOR signaling pathway

7 April 2017

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Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

29 September 2017

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

29 September 2017

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

29 September 2017

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Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures

29 September 2017

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

29 September 2017

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

29 September 2017

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IRS proteins and the common path to diabetes

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

29 September 2017

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Ribosomal S6 kinase signaling and the control of translation

29 September 2017

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

21 January 2018

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system

21 January 2018

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12 December 2020

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

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Identifiers

DOI

10.1083/JCB.200403069

1 reference

1 reference

1 reference

1 reference