Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent (Q28593855)

31 January 2017

title

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent (English)

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31 January 2017

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GOA release 2020-03-11

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1 reference

Angela Hodges

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Anja Jaeschke

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31 January 2017

Joerg Hartkamp

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31 January 2017

Masao Saitoh

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31 January 2017

Wendy Roworth

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31 January 2017

Takahiro Nobukuni

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31 January 2017

Julian Sampson

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31 January 2017

George Thomas

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31 January 2017

Richard Lamb

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31 January 2017

language of work or name

English

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publication date

28 October 2002

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31 January 2017

published in

Journal of Cell Biology

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31 January 2017

volume

159

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31 January 2017

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31 January 2017

page(s)

217–224

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

17 March 2017

1 reference

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

17 March 2017

1 reference

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Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

17 March 2017

1 reference

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A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

17 March 2017

1 reference

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Oncogenic kinase signalling

17 March 2017

1 reference

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Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

17 March 2017

1 reference

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

17 March 2017

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

17 March 2017

1 reference

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Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

17 March 2017

1 reference

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Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

17 March 2017

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Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

17 March 2017

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

17 March 2017

1 reference

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

17 March 2017

1 reference

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Phosphorylation and activation of p70s6k by PDK1

17 March 2017

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

17 March 2017

1 reference

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

17 March 2017

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

17 March 2017

1 reference

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Akt regulates growth by directly phosphorylating Tsc2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Regulation of translation initiation by FRAP/mTOR

7 April 2017

1 reference

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

7 April 2017

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Mammalian TOR: a homeostatic ATP sensor

7 April 2017

1 reference

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

The genetic basis of tuberous sclerosis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12403809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.JCB.200206108

1 reference

31 January 2017

0 references

1 reference