Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP (Q24321559)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071124

Protein tyrosine phosphatase non-receptor type 2

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integrin subunit alpha 1

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positive regulation of phosphoprotein phosphatase activity

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Integrin alpha 1

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Johanna Ivaska

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Elina Mattila

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Teijo Pellinen

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Jonna Nevo

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Karoliina Vuoriluoto

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Antti Arjonen

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

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language of work or name

English

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publication date

January 2005

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78-85

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cites work

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Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

20 April 2017

1 reference

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

20 April 2017

1 reference

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

20 April 2017

1 reference

Protein tyrosine phosphatases in the human genome

20 April 2017

1 reference

The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling

20 April 2017

1 reference

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

20 April 2017

1 reference

Integrins: bidirectional, allosteric signaling machines

20 April 2017

1 reference

PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

20 April 2017

1 reference

7 January 2021

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

1 reference

7 January 2021

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

1 reference

7 January 2021

Integrin signaling and cell growth control

1 reference

7 January 2021

Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

1 reference

7 January 2021

Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.

1 reference

7 January 2021

Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase

1 reference

7 January 2021

Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase

1 reference

7 January 2021

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

1 reference

7 January 2021

The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism

1 reference

7 January 2021

Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo

1 reference

7 January 2021

Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase

1 reference

7 January 2021

Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells

1 reference

7 January 2021

The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.

1 reference

7 January 2021

Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

1 reference

7 January 2021

5q11, 8p11, and 10q22 are recurrent chromosomal breakpoints in prostate cancer cell lines

1 reference

7 January 2021

Loss of heterozygosity is related to p53 mutations and smoking in lung cancer

1 reference

7 January 2021

PKC epsilon controls the traffic of beta1 integrins in motile cells

1 reference

7 January 2021

Oncogenic potential of a dominant negative mutant of interferon regulatory factor 3.

1 reference

7 January 2021