BCL2 like 1 (Q21173156)

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mammalian protein found in Homo sapiens
  • protein phosphatase 1, regulatory subunit 52
  • bcl-2-like protein 1
  • BCL2L1
  • apoptosis regulator Bcl-X
edit
Language Label Description Also known as
English
BCL2 like 1
mammalian protein found in Homo sapiens
  • protein phosphatase 1, regulatory subunit 52
  • bcl-2-like protein 1
  • BCL2L1
  • apoptosis regulator Bcl-X

Statements

molecular function
protein binding
determination method or standard
IPI
55 references
retrieved
8 April 2019
stated in
PUMA induces the rapid apoptosis of colorectal cancer cells
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAST is a BCL-X(L)-associated mitochondrial protein
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-G, a novel pro-apoptotic member of the Bcl-2 family
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DNA-binding domain mediates both nuclear and cytosolic functions of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
High-throughput methods to detect dimerization of Bcl-2 family proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human Bop is a novel BH3-only member of the Bcl-2 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-XL inhibits membrane permeabilization by competing with Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817
determination method or standard
IPI
cell component
mitochondrial outer membrane
determination method or standard
IBA
IDA
IEA
NAS
TAS
6 references
retrieved
21 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
TAS
retrieved
21 June 2018
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
NAS
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IEA
retrieved
21 June 2018
stated in
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IDA
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IBA
biological process
negative regulation of apoptotic process
determination method or standard
IDA
IEA
IMP
5 references
retrieved
21 June 2018
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IMP
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IEA
retrieved
21 June 2018
stated in
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IDA
retrieved
21 June 2018
stated in
Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain
GOA
curator
UniProt
UniProt protein ID
Q07817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IDA
retrieved
21 June 2018
stated in
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07817&geneProductId=UniProtKB:Q07817
determination method or standard
IDA

Identifiers

DeCS ID
50808
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21173156&oldid=2023035353"