A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways (Q24317698)

SRC proto-oncogene, non-receptor tyrosine kinase

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Receptor for activated C kinase 1

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BCL2 associated X, apoptosis regulator

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Inhibition of Bax channel-forming activity by Bcl-2

author name string

V Mamidipudi

series ordinal

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C A Cartwright

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language of work or name

English

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publication date

17 December 2009

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4421-33

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cites work

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Regulation of Akt/PKB activation by tyrosine phosphorylation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

No death without life: vital functions of apoptotic effectors

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Clusterin inhibits apoptosis by interacting with activated Bax

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.293

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1: a novel substrate for the Src protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

The Akt/PKB pathway: molecular target for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Intracellular transport mechanisms of signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

The hepatitis B virus HBx protein inhibits caspase 3 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Apoptotic pathways: ten minutes to dead

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Epsilon protein kinase C as a potential therapeutic target for the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1 inhibits the serum- and anchorage-independent growth of v-Src transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1 regulates G1/S progression by suppressing Src kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

14-3-3 proteins: regulation of subcellular localization by molecular interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Caspase activation: revisiting the induced proximity model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Peptide modulators of protein-protein interactions in intracellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Identification of a tumour suppressor network opposing nuclear Akt function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Src activation regulates anoikis in human colon tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Bcl-2 family proteins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Akt regulates cell survival and apoptosis at a postmitochondrial level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.293