Amyloid beta precursor protein (Q423510)

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mammalian protein found in Homo sapiens
  • amyloid precursor protein
  • beta-amyloid peptide
  • amyloid-beta precursor protein
  • ABPP
  • PN-II
  • alzheimer disease amyloid protein
  • testicular tissue protein Li 2
  • APP
  • beta-amyloid peptide(1-40)
  • amyloid beta A4 protein
  • protease nexin-II
  • APPI
  • amyloid-beta A4 protein
  • cerebral vascular amyloid peptide
  • CVAP
  • beta-amyloid precursor protein
  • amyloid beta (A4) precursor protein
  • peptidase nexin-II
  • preA4
  • beta-amyloid peptide(1-42)
edit
Language Label Description Also known as
English
Amyloid beta precursor protein
mammalian protein found in Homo sapiens
  • amyloid precursor protein
  • beta-amyloid peptide
  • amyloid-beta precursor protein
  • ABPP
  • PN-II
  • alzheimer disease amyloid protein
  • testicular tissue protein Li 2
  • APP
  • beta-amyloid peptide(1-40)
  • amyloid beta A4 protein
  • protease nexin-II
  • APPI
  • amyloid-beta A4 protein
  • cerebral vascular amyloid peptide
  • CVAP
  • beta-amyloid precursor protein
  • amyloid beta (A4) precursor protein
  • peptidase nexin-II
  • preA4
  • beta-amyloid peptide(1-42)

Statements

part of
molecular function
protein binding
determination method or standard
IPI
47 references
retrieved
9 May 2019
stated in
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Impact of the cellular prion protein on amyloid-β and 3PO-tau processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Cystatin C modulates cerebral beta-amyloidosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
CD74 interacts with APP and suppresses the production of Abeta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
GOA
curator
Alzheimers Project at University of Toronto
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
identical protein binding
determination method or standard
IPI
20 references
retrieved
9 May 2019
stated in
Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
A comparative analysis of the aggregation behavior of amyloid-β peptide variants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Lysophosphatidylcholine modulates fibril formation of amyloid beta peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
NMR characterization of the interaction of GroEL with amyloid β as a model ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction between soluble Aβ-(1-40) monomer and Aβ-(1-42) fibrils probed by paramagnetic relaxation enhancement
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
Lipid matrix plays a role in Abeta fibril kinetics and morphology
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
retrieved
9 May 2019
stated in
N-terminal domain of Pyrococcus furiosus l-asparaginase functions as a non-specific, stable, molecular chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IPI
cell component
plasma membrane
determination method or standard
IDA
IEA
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IEA
retrieved
9 May 2019
stated in
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IDA
retrieved
9 May 2019
stated in
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein
GOA
curator
UniProt
UniProt protein ID
P05067
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IDA
retrieved
9 May 2019
stated in
Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IDA
retrieved
9 May 2019
stated in
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IDA
biological process
learning or memory
determination method or standard
IGI
IMP
TAS
10 references
retrieved
9 May 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
TAS
retrieved
9 May 2019
stated in
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IMP
retrieved
9 May 2019
stated in
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IMP
retrieved
9 May 2019
stated in
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Memory impairment in transgenic Alzheimer mice requires cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
positive regulation of gene expression
determination method or standard
IGI
IMP
6 references
retrieved
9 May 2019
stated in
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IMP
retrieved
9 May 2019
stated in
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IMP
retrieved
9 May 2019
stated in
ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
retrieved
9 May 2019
stated in
Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067
determination method or standard
IGI
has part(s)
Commons category
Amyloid precursor protein
0 references

Identifiers

Microsoft Academic ID
31705614
0 references
2908769674
0 references
PDB structure ID
 
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