Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease (Q24298553)

Solute carrier family 40 (iron-regulated transporter), member 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Robert D Moir

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Timothy Johanssen

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Jack T Rogers

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James A Duce

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Simon A James

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Roberto Cappai

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Ashley I Bush

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Colin L Masters

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Rudolph E. Tanzi

Rudolph E Tanzi

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Catriona A. McLean

Catriona McLean

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Andrew Tsatsanis

Andrew Tsatsanis

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Elysia Robb

Elysia Robb

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Keyla Perez

Keyla Perez

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Kevin J Barnham

Kevin J Barnham

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Krutika Wikhe

Giuseppe Donato Ciccotosto

Krutika Wikhe

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Giuseppe D Ciccotosto

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author name string

Michael A Cater

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Su Ling Leong

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Mark A Greenough

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Hyun-Hee Cho

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Denise Galatis

Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice

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language of work or name

English

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publication date

17 September 2010

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published in

Cell

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volume

142

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issue

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page(s)

857-67

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cites work

1 reference

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Aceruloplasminemia: molecular characterization of this disorder of iron metabolism

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The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

19 March 2017

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Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

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Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

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Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

19 March 2017

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Kinetic Studies of Ferrous Ion Oxidation with Crystalline Human Ferroxidase (Ceruloplasmin)

19 March 2017

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Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts

19 March 2017

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Iron, brain ageing and neurodegenerative disorders

19 March 2017

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RETRACTED: The hepcidin-binding site on ferroportin is evolutionarily conserved

7 April 2017

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

27 September 2017

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

27 September 2017

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Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart.

27 September 2017

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Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

27 September 2017

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The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

27 September 2017

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

27 September 2017

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

27 September 2017

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MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease

27 September 2017

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

27 September 2017

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Ceruloplasmin gene expression in the murine central nervous system

27 September 2017

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Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth

27 September 2017

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Regulating the fate of mRNA: the control of cellular iron metabolism

27 September 2017

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Widespread expression of amyloid beta-protein precursor gene in rat brain

27 September 2017

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Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

27 September 2017

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Iron levels modulate alpha-secretase cleavage of amyloid precursor protein

27 September 2017

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Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin

27 September 2017

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30 May 2018

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In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice

30 May 2018

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

30 May 2018

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Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease

30 May 2018

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

30 May 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques

30 May 2018

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Reaction paths of iron oxidation and hydrolysis in horse spleen and recombinant human ferritins.

30 May 2018

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Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes

30 May 2018

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In vivo MR evaluation of age-related increases in brain iron.

30 May 2018

1 reference

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

30 May 2018

1 reference

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Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Redox active iron accumulation in aceruloplasminemia

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

29 November 2018

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Exploring mental status in Friedreich's ataxia: a combined neuropsychological, behavioral and neuroimaging study

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Elevated cortical zinc in Alzheimer disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

29 November 2018

1 reference

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Characterization and modulation of the transferrin receptor on brain capillary endothelial cells

29 November 2018

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The effect of age on the non-haemin iron in the human brain.

29 November 2018

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Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

29 November 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

29 November 2018

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Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

29 November 2018

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

29 November 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

29 November 2018

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Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943017

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

29 November 2018

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In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI.

29 November 2018

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Iron incorporation into apoferritin. The role of apoferritin as a ferroxidase

29 November 2018

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High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites

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Induction of beta-amyloid precursor protein isoform mRNAs by bFGF in astrocytes

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Identification of the ferroxidase centre in ferritin

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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

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Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth.

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

20817278

1 reference