Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis (Q39738242)

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Language	Label	Description	Also known as
English	Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

author name string

Jodi R Alt

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Timothy C Greiner

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

John L Cleveland

3

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Christine M Eischen

4

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

language of work or name

0 references

publication date

1 March 2003

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

The EMBO Journal

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

22

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

1442-1450

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

ARF function does not require p53 stabilization or Mdm2 relocalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

p53-independent functions of the p19(ARF) tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Cellular senescence: mitotic clock or culture shock?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The MDM2 gene amplification database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

14 September 2017

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

25 September 2017

Mdm-2: "big brother" of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

25 September 2017

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

25 September 2017

Overexpression of the MDM2 oncogene in leukemia and lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

15 June 2018

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

20 August 2018

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151074

20 August 2018

The loss of mdm2 induces p53-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 gene family and the regulation of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12628936

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/EMBOJ/CDG133

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

release_k43aqdpfevdrphdfqp2bpnfeva

1 reference

https://api.fatcat.wiki/v0/release/k43aqdpfevdrphdfqp2bpnfeva

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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